ISSN:
1432-2072
Keywords:
Seizure
;
Genetics
;
Brain Amines
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary DBA/2J mice, susceptible to audiogenic seizures, were found to be more susceptible to pentylenetetrazol- and electrically-induced seizures than either C57BL/6J or F1 hybrid mice, which are resistant to audiogenic seizures. Reserpine increased susceptibility to both pentylenetetrazol and electroconvulsive seizures in C57BL/6J, DBA/2J and F1 hybrid mice. 5-hydroxytrptophan, iproniazid and amino-oxyacetic acid decreased seizure susceptibility in all groups of mice. These results were interpreted to mean that DBA/2J mice are more susceptible to seizures than C57BL/6J or F1 hybrid mice regardless of the agents used to induce the seizures, and that levels of 5-HT, NE and GABA are important in determining seizure thresholds.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00401398
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