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  • 1
    ISSN: 1460-9568
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Several lines of evidence indicate that augmented neuronal activity is associated with increased mitochondrial function, however, the mechanisms of coupling are still unclear. In this study we used a low extracellular Mg2+ concentration and short stimulus trains to evoke neuronal hyperactivity in the form of seizure-like events (SLE) in hippocampal slice cultures. Simultaneous microfluorimetric and electrophysiological techniques were applied to gain insight into changes of Ca2+ concentration in different compartments and into mitochondrial function. SLEs were associated with a large decrease of the extracellular Ca2+ concentration ([Ca2+]e), a spiking increase of the cytoplasmic and a smoothed elevation of the mitochondrial Ca2+ concentration (cytoplasmic concentration [Ca2+]i; intramitrochondrial concentration [Ca2+]m). Following an initial apparent decline in the mitochondrial membrane potential (ΔΨ) and NAD(P)H autofluorescence, mitochondria depolarized and NADH production was augmented. Furthermore, SLEs were associated with increased oxidation of dihydroethidine (HEt). Our data suggest that intramitochondrial Ca2+ accumulation stimulates NADH production and production of radical oxygen species (ROS). Interestingly, mitochondrial depolarization followed [Ca2+]i and [Ca2+]m changes with a delay implying that electrogenic extrusion of Ca2+ from the mitochondrial matrix might be responsible for the depolarization of the mitochondrial membrane.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 45 (1985), S. 0 
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: Replacement of H2O by D2O resulted in significantly higher amount of [3H]diazepam specifically bound to synaptic membranes. The isotope effect arises from increased number of binding sites in D2O and is associated with a stronger solvation of membrane receptors by heavy water.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Spectrochimica Acta Part B: Atomic Spectroscopy 42 (1987), S. 765-771 
    ISSN: 0584-8547
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Tetrahedron Letters 15 (1974), S. 2685-2688 
    ISSN: 0040-4039
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Tetrahedron Letters 16 (1975), S. 565-568 
    ISSN: 0040-4039
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy Section 32 (1976), S. 1387-1392 
    ISSN: 0584-8539
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Tetrahedron Letters 16 (1975), S. 1631-1632 
    ISSN: 0040-4039
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Cellular and molecular life sciences 36 (1980), S. 1031-1032 
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Dihydrodiazepam is a diazepam prodrug, as shown by its in vitro metabolism by rat and mouse liver and brain microsomal fractions, and its displacing activity on brain diazepam binding. The mechanism of bioactivation is discussed. Stereoselectivity of metabolism and of binding to specific benzodiazepine binding sites in brain synpatosomes and serum albumin were studied.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Colloid & polymer science 204 (1965), S. 1-7 
    ISSN: 1435-1536
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Description / Table of Contents: Zusammenfassung Die wiedergegebenen Daten zeigen für Polyäthylen mittlerer Dichte, das wie lineares Polyäthylen sowohl mit gestreckten Ketten wie mit gefalteten Ketten kristallisieren kann, daß die Verzweigungen einen wesentlichen Einfluß auf die Leichtigkeit der Ausbildung von gestreckten Ketten haben. Außerdem besitzen beide Typen von Kristallen verschiedene Schmelzpunkte, gemessen mittels DTA. Ein endothermer Pik würde dem Einsetzen von Rotationen zuzuordnen sein und tritt kurz unterhalb des bezüglichen Schmelzpiks der entsprechenden Kristallart auf. Das Schmelzen besteht nicht in einem vollständigen Verschwinden der Ordnung. Wenn eine Probe kurz über dem Schmelzpunkt für nicht zu lange Zeit gehalten wird, verbleiben genügend Keime, um Kristallisation bei höherer Temperatur zu erzeugen als der angewendeten Abkühlungsgeschwindigkeit entspricht. Diese Kristallisation bei 1 Athmosphäre läuft ab unter Faltung auch dann, wenn die Keime aus dem Aufschmelzen gestreckter Kristalle stammen. Zusätzlich zur Fraktionierung und Segregation nach dem Molekulargewicht während der Kristallisation unter Druck, für welche einige Hinweise präsentiert werden, ergeben die Kristalle weitere Hinweise, daß die Fraktionierung durch den Gehalt an Verzweigung eintritt.
    Notes: Summary The results presented here demonstrate that although medium-density polyethylene in addition to linear polyethylene can crystallize in extended-chain as well as folded-chain crystals, the branches have a significant effect on the ease of forming extended-chain crystals. Besides the two types of crystals having different melting points, as measured by DTA, an endothermic peak assumed to be due to the onset of rotational motion and located just below the respective melting peaks is associated with each type of crystal. Melting itself does not result in a complete disappearance of order; if the sample is held just above the melting point for a short period of time sufficient seed nuclei remain to produce crystallization at a higher temperature than commensurate with the cooling rate employed. This crystallization at atmospheric pressure takes place through chain folding even though the nuclei are remnants of extended-chain crystals. In addition to fractionation and segregation by molecular weight during crystallization under pressure, for which some further evidence is presented, the results obtained here suggest that fractionation by branching content may also occur.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Stamford, Conn. [u.a.] : Wiley-Blackwell
    Polymer Engineering and Science 32 (1992), S. 221-230 
    ISSN: 0032-3888
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: A critical part of any master model used to simulate or control a composite material manufacturing process is the description of resin flow through the fiber bed. We present here a review of both theoretical and experimental studies of fluid flow through porous media, including fiber beds. For the practical porosity range of interest in continuous fiber composites processing (0.3〈 ∊ 〈 0.6), the permeability cannot be accurately described using the Blake-Kozeny-Carman equation, even though the flow is Newtonian at very low Reynold's number. For aligned fiber situations, the Kozeny constant, k, deviates radically from theory, depends on bed nonuniformities, and is only constant over very narrow porosity ranges. Thus, one cannot experimentally determine k at high porosities and use this value to describe low porosity situations. Theoretical attempts, based on perfectly spaced and aligned arrays of cylinders, adequately describe the transverse permeability of ideal fiber beds in the high porosity range, but do not succeed at porosities below 0.6. For axial flow through aligned fiber beds, the theory yields permeabilities much lower than are experimentally observed throughout the entire porosity range. For randomly arranged fibers, random cylinder theory also predicts permeabilities that are significantly lower than are measured.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
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