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  • 1
    Electronic Resource
    Electronic Resource
    Breath H2 test for lactase deficiency (1977)
    Springer
    Digestive diseases and sciences 22 (1977), S. 745-746 
    Details
    ISSN: 1573-2568
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01078359
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Esophageal acid clearance during sleep in patients with Barrett's esophagus (1988)
    Springer
    Digestive diseases and sciences 33 (1988), S. 654-659 
    Details
    ISSN: 1573-2568
    Keywords: gastroesophageal reflux ; sleep ; Barrett's esophagus ; acid clearance
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Sleep-related gastroesophageal reflux and esophageal acid clearance have been shown to be important components in the pathogenesis of reflux esophageal disease. Previous studies have suggested that patients with more severe esophagitis are distinguished by an accumulation of acid mucosal contact time during sleep. These data would suggest that patients with Barrett's esophagus should have particularly severe impairment of acid clearance, most notable during sleep. To address this issue, 16 asymptomatic healthy volunteers and 13 patients with Barrett's esophagus were studied. Acid clearance was assessed by timing the reestablishment of an esophageal pH of 4 following the infusion of 15 ml 0.1 N HCl. Sleep was poly graphically monitored in order to objectively determine sleep and waking. The results indicated that while patients with Barrett's esophagus had a marked increase in the frequency of spontaneous gastroesophageal reflux during sleep, they unexpectedly demonstrated faster acid clearance times during both waking and sleep. A greater percentage of arousal responses to acid infusion during sleep was noted in the Barrett's group. It is concluded from these results that patients with Barrett's esophagus can adequately clear acid from the distal esophagus but experience considerable acid mucosal contact through repeated episodes of spontaneous reflux during sleep.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01540426
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Observations on the effects of glucocorticoid administration in pernicious anemia (1970)
    Springer
    Digestive diseases and sciences 15 (1970), S. 871-881 
    Details
    ISSN: 1573-2568
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The present study was an attempt to document further the changes that occur in patients with pernicious anemia during and after prednisolone. Therefore, 11 such patients were studied before, during 9–14 weeks of prednisolone administration, and up to 12 months afterwards. Schilling urinary excretion tests (UET) became normal in 5 patients, and 3 others had suboptimal improvement. Gastric juice intrinsic factor (IF) was demonstrated in 3 patients before prednisolone administration and 8 had increased amounts during therapy. Four patients had serum IF antibodies, and all titers declined. Parietal cells were present in gastric mucosal specimens from 9 of 11 individuals before, and from 7 of 9 individuals at the end of prednisolone administration. No clear relationship between an improvement of UET was demonstrable with the following: dosage or duration of prednisolone administration, degree of hypercorticism induced, presence of IF antibodies, or changes in gastric mucosa. The initial UET and/or gastric juice IF assay appeared higher in those who responded by improving their UET to normal, compared to those who had suboptimal or no UET improvement.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02236052
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Effects of in-vitro neutralization on the composition of the nondialyzable components of human gastric juice (1967)
    Springer
    Digestive diseases and sciences 12 (1967), S. 389-395 
    Details
    ISSN: 1573-2568
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The first 30-min. gastric juice specimen following augmented histamine stimulation was collected from 32 patients. After measuring the volume and pH, each sample was divided into 2 equal parts, and one half was neutralized to pH 7.0. The paired samples were individually dialyzed and lyophilized, and their weight, hexose and nitrogen content, proteolytic enzyme activity, and B12 binding capacity were determined. When the paired samples were compared, in-vitro neutralization and dialysis reduced the concentration of the proteolytic enzyme activity and increased the concentration of hexoses and B12binding materials. In-vitro neutralization and dialysis reduced the weight of the samples and the total proteolytic enzyme activity, while the total B12 binding material was increased. The nitrogen concentration was reduced also by in-vitro neutralization and dialysis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02241941
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  • 5
    Electronic Resource
    Electronic Resource
    Relationship between the changes in gastrin levels and intestinal properties in the starved rat (1976)
    Springer
    Digestive diseases and sciences 21 (1976), S. 33-38 
    Details
    ISSN: 1573-2568
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Intestinal DNA, RNA, and protein content were decreased to a greater extent than was body weight when rats were starved for 3 days. Specific lactase and maltase activity increased with progressively longer periods of starvation. Antral and serum gastrin concentration significantly decreased during the 3 days of starvation. Pentagastrin (250 μg/kg 3 times daily) was injected into a group of rats for the duration of a 3-day starvation period and caused a small but significant increase in the relative intestinal RNA and protein content and decreased lactase and maltase specific activities in comparison with the levels of 3-day starved controls. Pentagastrin thus partially reversed some of the starvation-induced changes toward fed levels. Thus, a deficiency in the trophic hormone gastrin may be partially responsible for the disproportionate changes in intestinal tissue during starvation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01074136
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Vascular responses in the exposed human colon (1960)
    Springer
    Digestive diseases and sciences 5 (1960), S. 579-602 
    Details
    ISSN: 1573-2568
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02290192
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    Paper (German National Licenses)
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  • 7
    Electronic Resource
    Electronic Resource
    Portal cirrhosis in alcoholic and nonalcoholic women (1962)
    Springer
    Digestive diseases and sciences 7 (1962), S. 84-92 
    Details
    ISSN: 1573-2568
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary 1. During a 10-year period 59 women with portal cirrhosis were hospitalized at the University of Oklahoma Hospital. Approximately half of the patients were alcoholic. Twenty-one of the nonalcoholic and 12 of the alcoholic women and diagnoses of portal cirrhosis supported by examination of hepatic tissue. These 33 patients with tissue diagnosis are compared in detail. 2. The alcoholic women were younger at the onset of their symptoms and were commonly from urban areas. The initial clinical diagnosis on these patients was usually cirrhosis, since they frequently had the symptoms, physical findings, and abnormal hepatic function tests associated with this disease. 3. The nonalcholic women were on the average older at the onset of their symptoms. Since they usually had abdominal pain and ascites without many of the expected physical findings of cirrhosis, their initial clinical diagnoses were frequently incorrect. Arterial hypertension or other extrahepatic disease occurred in the majority. A high index of suspicion and a liver biopsy are needed to make the diagnosis in these patients. 4. The possible etiologic factors leading to cryptogenic portal cirrhosis in the nonalcoholic women are discussed briefly.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02231934
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    Paper (German National Licenses)
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  • 8
    Electronic Resource
    Electronic Resource
    Colon blood flow (1963)
    Springer
    Digestive diseases and sciences 8 (1963), S. 614-622 
    Details
    ISSN: 1573-2568
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary and Conclusion 1. The intramural blood vessels of the human colon have been described. 2. Five methods that have been used to study colonic mucosal blood flow in patients with colostomies or with normal colons were briefly outlined along with some of the limitations of each technic. 3. It has been shown that the colonic mucosal blood flow in the human responds to heating or cooling an extremity, eating a meal, pharmacologic agents, and emotionally stressful situations. 4. Adequate evaluation of colonic mucosal blood flow requires the development of quantitative technics of measurement. It may be that methods of monitoring radioactive indicators with critically shielded detectors may meet some of these needs16 and offer a way of studying the intact colon of an unanesthetized human subject.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02239458
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    Paper (German National Licenses)
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  • 9
    Electronic Resource
    Electronic Resource
    Roentgenographic mucosal patterns in the “malabsorption syndrome“ (1968)
    Springer
    Digestive diseases and sciences 13 (1968), S. 59-78 
    Details
    ISSN: 1573-2568
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A reevaluation was undertaken of roentgenographic findings as seen in diseases producing malabsorption. Seventy-nine cases were reviewed of patients having both small-bowel series and small-bowel biopsies. The emphasis was on the evaluation of roentgenographic small-bowel mucosal patterns and their correlation with histologic changes. Absorption test results were reviewed and the patients were then grouped and discussed on the following bases: (1) normals (controls), (2) those with adult celiac disease (treated and untreated), (3) those patients with diseases manifesting primarily in thickened mucosal folds, (4) those patients having had a gastrectomy, and (5) a miscellaneous group. Criteria for satisfactory differentiation between these diseases or disease groups was developed and a practical approach to the roentgenographic differentiation of these diseases was outlined.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02239211
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  • 10
    Electronic Resource
    Electronic Resource
    The baker-hughes gastrointestinal biopsy tube (1966)
    Springer
    Digestive diseases and sciences 11 (1966), S. 559-563 
    Details
    ISSN: 1573-2568
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A total of 236 gastric and small-intestine specimens have been obtained from 68 patients on 85 occasions with the Baker-Hughes multiple-retrieving gastro-intestinal biopsy tube. The biopsy technic was the same as that originally described with only a few modifications which are presented. Thirty-five gastric specimens were obtained from 19 patients. In each case, the amount of tissue was adequate. Two hundred and one small-intestine specimens were obtained from 62 patients, and tissue for histologic examination was adequate in 193. Although functioning on hydraulic principles, the Baker-Hughes biopsy tube requires no specialized pumping apparatus for delivery of the tissue and, therefore, has the advantages of economy and simplicity of operation. On 5 of the 85 occasions we have used the Baker-Hughes multiple-retrieving biopsy tube, there have been complications: 2 patients had bleeding and 3 had a “postbiopsy syndrome.”
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02233568
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    Paper (German National Licenses)
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