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  • 1
    Digitale Medien
    Digitale Medien
    Kinetic analysis of chloride conductance in frog skeletal muscle at pH 5 (1991)
    Springer
    Pflügers Archiv 419 (1991), S. 522-528 
    Details
    ISSN: 1432-2013
    Schlagwort(e): Muscle ; Chloride conductance ; Voltage clamp ; Acid
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract At pH 5 the steady-state chloride chord conductance in frog skeletal muscle rises to an asymptotic maximum at very negative voltages and approaches an asymptotic minimum at positive voltages. When a two-pulse test paradigm is used, the conductance computed from steady-state currents during the first (conditioning) voltage step are not duplicated by the conductance at the onset of a second (test) step. If the test step is to a more negative voltage than the conditioning step the steady-state conductance is overestimated; if it is to a less negative voltage the conductance is underestimated. In some fibres the initial currents accompanying steps from the resting potential are inwardly rectified. From this it was inferred that chloride channel conductance is voltage dependent: in those fibres in which no such initial inward rectification was observed it was inferred that at rest the voltage-dependent chloride channels are all closed. Time-dependent (“gated”) changes of conductance could be reasonably described by a first-order process, but the relaxations were not simple exponentials. Simulation of the experimental set-up predicted the type of deviation from exponentiality seen experimentally, although the observed deviations were often more pronounced than those predicted.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00370799
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    SCoP: An interactive simulation control program for micro- and minicomputers (1986)
    Springer
    Bulletin of mathematical biology 48 (1986), S. 427-441 
    Details
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract A nes software system is described for building simulation programs on micro- and minicomputers. Model equations are written as C subroutines, compiled and linked to the SCoP package to produce a menu-driven, interactive program. The system maintains a database of names, values, and units for all model parameters and variables. Run-time options include several methods for interactive parameter modification and both graphic and tabular outputs, with output values presented as they are calculated. Simulation output values can be compared with experimental data graphically and a companion program SCoPFit is provided for formal optimization of parameter values.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02459691
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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