ISSN:
0091-7419
Schlagwort(e):
Fc fragments
;
immune complexes
;
macrophages
;
polyclonal antibody response
;
Life Sciences
;
Molecular Cell Biology
Quelle:
Wiley InterScience Backfile Collection 1832-2000
Thema:
Biologie
,
Chemie und Pharmazie
,
Medizin
Notizen:
Murine splenic B lymphocytes are induced to proliferate and undergo polyclonal activation in the presence of Fc fragments, AHGG, antigen-antibody complexes, and CH3 fragments derived from plasmin digestion of human Ig. The unifying feature of the polyclonal antibody response induced by these agents is that in all cases a portion of the constant region of the Ig molecule (ie, Fc region) is present. Fragments of Ig lacking the Fc piece, such as Fab and F(ab′)2 were found not to be stimulatory. In addition, a model is proposed to account for the regulatory effects of antigen-antibody complexes on an ongoing humoral immune response.
Zusätzliches Material:
2 Ill.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1002/jss.400140208
Permalink