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  • 1
    Digitale Medien
    Digitale Medien
    Response to bronchodilators in clinically stable 1-year-old patients with bronchopulmonary dysplasia (1997)
    Springer
    European journal of pediatrics 157 (1997), S. 75-79 
    Details
    ISSN: 1432-1076
    Schlagwort(e): Key words Bronchopulmonary dysplasia Bronchodilators ; Pulmonary function
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Bronchodilators are often used in the treatment of patients with bronchopulmonary dysplasia (BPD). However, few studies evaluate their efficacy in patients with stable disease beyond the newborn period. Therefore, pulmonary function was measured before and after aerosol treatment with salbutamol (0.25 ml Ventolin 0.5%) and subsequently after aerosol with ipratropium bromide (0.25 ml Atrovent 0.025%). Studies were performed at the corrected postnatal age of 52±2 weeks in 52 patients who had been ventilated after birth because of newborn lung disease. Twenty-two of these 52 patients had developed BPD. Pulmonary function was measured after sedation and using the PEDS system. Expiratory resistance (median 52.1 versus 39.1 cmH2O/l/s; P〈.008) and inspiratory resistance (median 42.5 vs 27.8 cmH2O/l/s; P〈.04) were significantly worse in BPD patients at the age of 1 year. Half of the BPD patients had a decrease in pulmonary resistance after salbutamol. However, there was no statistically significant decrease in pulmonary resistance after salbutamol or ipratropium in the BPD patients as a group. After salbutamol pulmonary resistance significantly worsened in the patients who did not develop BPD. Conclusion Although individual patients may benefit, routine administration of bron chodilators seems not warranted in stable BPD patients at the age of 1 year.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s004310050771
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  • 2
    Digitale Medien
    Digitale Medien
    Evaluation of Three Software Programs for Calculating True-Coincidence Summing Correction Factors (2000)
    Springer
    Journal of radioanalytical and nuclear chemistry 244 (2000), S. 675-680 
    Details
    ISSN: 1588-2780
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Energietechnik
    Notizen: Abstract True-coincidence summing correction is an essential element in k 0-based NAA1 and becomes important when samples are counted with a high efficiency detector. This may be the case where large detectors are used or where samples are counted in or in the vicinity of the detector in order to achieve low detection limits in conjunction with low-flux reactors. In some laboratories coincidence correction is accomplished by calculating the coincidence correction factors. Since experimental validation of the calculations will reveal only the most significant errors and is a laborious task due to the high number of radionuclides involved, three laboratories decided to compare their calculated coincidence factors. Each laboratory uses a different software package. A comparative performance analysis was made of COINCALC developed at the INW of the University of Gent (implemented in SOLCOI by DSM Research), the software of the IRI, University of Delft, the Netherlands, and the software of the Ecole Polytechnique, Montreal, Canada. The overall approach, data and algorithms were chosen independently by each institute as the software was being developed and, so, the comparison has yielded a number of interesting conclusions. A follow-up investigation of the discrepancies found will probably allow the performance of each program to be improved.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1023/A:1006718812155
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  • 3
    Digitale Medien
    Digitale Medien
    New Experimental k0 and Related Data for Generalized Activation/Decay Cases Implemented in the "Kayzero" Software Package (2000)
    Springer
    Journal of radioanalytical and nuclear chemistry 245 (2000), S. 179-184 
    Details
    ISSN: 1588-2780
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Energietechnik
    Notizen: Abstract A revision is made of some activation-decay types in k 0-NAA, aiming at the removal of (1) the inconvenience that a long-lived daughter radionuclide could in some instances only be measured after complete decay of a shorter-lived mother, and (2) the simplification that in some cases the measured gamma-ray emitted by the daughter radionuclide is not significantly contributed to by the mother. In view of this, new experimental and generalized k 0's and related data [Q 0, k 0(m)/k 0(g), etc.] for some analytically relevant activation-decay cases are presented for implementation in an updated version of the "Kayzero" software package. These cases are: 60mCo-60Co, 104mRh-104Rh, 109mPd-109Pd-109mAg, 122mSb-122Sb, 134mCs-134Cs, 199mPt-199Pt-199Au. For completeness, recent data for two additional cases are also included: 80mBr-80Br, 124m2Sb-124m1Sb.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1023/A:1006766323363
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  • 4
    Digitale Medien
    Digitale Medien
    The k0 and Q0 Values for the Zr-Isotopes: A Re-Investigation (2000)
    Springer
    Journal of radioanalytical and nuclear chemistry 245 (2000), S. 199-203 
    Details
    ISSN: 1588-2780
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Energietechnik
    Notizen: Abstract The k 0 and Q 0 values for 94Zr(n,γ)95Zr(E γ = 724.2+756.7 keV) and 96Zr(n,γ)97Zr(β−) 97mNb (E γ = 743.4 keV) were re-investigated. The aim was to further improve the reliability of the neutron spectrum characterization (f and α monitoring) in k 0-NAA, based on "bare monitor" methods with the use of these Zr radionuclides. So as to achieve this goal, experimental determinations were performed in three reactor centers: KFKI AEKI, Budapest (WWR-M reactor); INW, Gent (THETIS reactor); SCK·CEN, Mol (BR1 reactor). The results were: Q 0(94Zr) = 5.306; Q 0(96Zr) = 251.6; k 0(95Zr, 724.2+756.7 keV) = 2.000E-4; k 0(97Zr/97mNb, 743.4 keV) = 1.237E-5. This means that the newly evaluated k 0-values are about 4.7% lower than the formerly reported ones. It is also emphasized that the 97Zr half-life is 16.74 hours, contrary to the ∼1% higher values usually reported.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1023/A:1006759516520
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  • 5
    Digitale Medien
    Digitale Medien
    Increase in Penicillin Resistance Rates in Belgium due to Clonal Spread of a Penicillin-Resistant 23F Streptococcus pneumoniae Strain (1999)
    Springer
    European journal of clinical microbiology & infectious diseases 18 (1999), S. 120-125 
    Details
    ISSN: 1435-4373
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract  In 1994 a sudden increase in penicillin resistance was observed in Belgium among invasive pneumococci. To determine whether this increase was due to clonal spread of a resistant strain or to de novo acquisition of penicillin resistance, pneumococci of capsular types 23F, 19, 14, 9, and 6, isolated in 1993 and 1994, were analyzed by capsular serotyping and DNA macrorestriction analysis, resolved by pulsed-field gel electrophoresis. Furthermore, pneumococcal isolates from northern France, a region with a high prevalence of penicillin resistance, and from southern Belgium, a region with a low but increasing prevalence of penicillin resistance, were analyzed. The rate of resistance of invasive pneumococci to penicillin increased from 2.3% in 1993 to 7.6% in 1994. Pneumococcal serotype 23F represented 26.7% of the penicillin-resistant isolates in 1993 and 40.4% in 1994, while the prevalence of serotype 23F decreased from 10.9% in 1993 to 8.8% in 1994. In 1994 up to 35.8% of serotype 23F isolates were penicillin resistant. The Belgian penicillin-resistant 23F isolates from 1994 were genetically closely related to the French 23F penicillin-resistant isolates and, as clones were clearly distinct from the other serotypes as well as from the penicillin-susceptible 23F isolates. These data demonstrate the important contribution of the clonal spread of a penicillin-resistant pneumococcal strain in the overall increase of penicillin resistance in our country.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s100960050239
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