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  • 1
    Digitale Medien
    Digitale Medien
    Cell death and longevity: implications of Fas-mediated apoptosis in T-cell senescence (1997)
    Oxford, UK : Blackwell Publishing Ltd
    Immunological reviews 160 (1997), S. 0 
    Details
    ISSN: 1600-065X
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Summary: Two prominent features of immune senescence are altered T-cell phenotype and reduced T-cell response. We have previously shown that T-cell senescence is greatly reduced in CD2-fas transgenic mice, in which the Fas apoptosis molecule is constantly expressed on T cells. Using a different experimental approach, the relationship between T-cell senescence And apoptosis was analyzed on human peripheral blood mononuclear cells. The results indicate that there was increased apoptosis of CD45RO− (CD45RA+) T cells upon activation. We propose that this could account for the increase in CD45RO+“memory” T cells with aging in humans. T-cell responsiveness remained high in CD2-fas transgenic aged mice, but there was no increase in overall life span of these mice. Increased T-cell responsiveness was associated with an increased acute-phase response and serum amyloid A deposition in the glomerulus of aged CD2-fas transgenic mice. Therefore, restoration of the T-cell immune function using a CD2-fus transgene produced undesirable side-effects transgenic mice. In addition to its role in activation-Induced cell death. Fas-mediated apoptosis may be important in deleting T cells in response to DNA damage. It may also inhibit cell-cycle progression by cleaving various kinases and DNA repair enzymes. We observed that cell lines derived from human premature aging diseases have a higher sensitivity to Fas mediated apoptosis. The implications of these observations are discussed.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1600-065X.1997.tb01024.x
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  • 2
    Digitale Medien
    Digitale Medien
    Bisindolylmaleimide VIII facilitates Fas-mediated apoptosis and inhibits T cell-mediated autoimmune diseases (1999)
    [s.l.] : Nature America Inc.
    Nature medicine 5 (1999), S. 42-48 
    Details
    ISSN: 1546-170X
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Medizin
    Notizen: [Auszug] Fas-mediated apoptosis is essential for the elimination of cells, and impaired apoptosis can have severe detrimental consequences. Bisindolylmaleimide VIII potentiated Fas-mediated apoptosis in human astrocytoma 1321N1 cells and in Molt-4 T cells, both of which were devoid of apoptosis induced ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/4723
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  • 3
    Digitale Medien
    Digitale Medien
    Induction of specific T-cell tolerance by adenovirus-transfected, Fas ligand-producing antigen-presenting cells (1998)
    [s.l.] : Nature America Inc.
    Nature biotechnology 16 (1998), S. 1045-1049 
    Details
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] A major problem associated with adenovirus gene therapy is the T cell-mediated immune response, which is elicited by inoculation of the adenovirus vector and leads to rapid clearance of the virus and loss of transgene expression. In this study, the immune response to adenovirus was prevented by ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/3488
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  • 4
    Digitale Medien
    Digitale Medien
    Tumoricidal activity of a novel anti-human DR5 monoclonal antibody without hepatocyte cytotoxicity (2001)
    [s.l.] : Nature Publishing Group
    Nature medicine 7 (2001), S. 954-960 
    Details
    ISSN: 1546-170X
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Medizin
    Notizen: [Auszug] A novel anti-human DR5 monoclonal antibody, TRA-8, induces apoptosis of most tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-sensitive tumor cells both in vitro and in vivo. In contrast to both the membrane-bound form of human TRAIL, which induced severe hepatitis in mice, and the ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/91000
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  • 5
    Digitale Medien
    Digitale Medien
    In Situ Crosslinking Induced Structure Development and Mechanical Properties of Nano-Silica/Polypropylene Composites (2007)
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 334-335 (Mar. 2007), p. 733-736 
    Details
    ISSN: 1013-9826
    Quelle: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Thema: Maschinenbau
    Notizen: In our previous works, a double percolation mechanism of stress volumes was proposed toexplain the special effects generated by small amounts of grafted nanoparticles. Accordingly, it isinferred that strengthening nanoparticle agglomerates and enhancing nanoparticles/polymer matrixinterfacial interaction are the key issues to improve mechanical performance of the matrix polymer.To confirm this idea, in-situ crosslinking was adopted to prepare nanocomposites by adding reactivemonomers and crosslinking agents during melt compounding of nano-silica with polypropylene (PP).It was found that the grafted polymer chains were successfully crosslinked and chemically bonded tothe nano-silica forming crosslinked networks. Meanwhile, matrix molecular chains penetratedthrough the networks to establish the so-called semi-IPN structure that interconnected nanoparticlesby the networks and improved filler/matrix interfacial interaction. As a result, the tiny nanoparticleswere well distributed in the matrix and the toughening and reinforcing effects of the nanoparticles onthe matrix were brought into play at rather low filler loading, as evidenced by mechanicalperformance tests. Besides, β-crystal was detected in the nanocomposites experienced in-situcrosslinking reaction
    Materialart: Digitale Medien
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/53/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.334-335.733.pdf
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  • 6
    Digitale Medien
    Digitale Medien
    Electrochemical Corrosion Behavior of Carbon Fiber/Vinyl Ester Resin Composite Used for Sucker Rods (2006)
    s.l. ; Stafa-Zurich, Switzerland
    Advanced materials research Vol. 11-12 (Feb. 2006), p. 505-508 
    Details
    ISSN: 1662-8985
    Quelle: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Thema: Maschinenbau
    Notizen: The electrochemical corrosion behavior of carbon fiber/vinyl ester resin composite(CF/VE), which has been used for sucker rods in the oil field, was studied under an immersioncondition of 3% NaCl aqueous solution at 65°C. Galvanic corrosion experiment between the CF/VEcomposite and the alloy used as joints linking the composite sucker rods and metal suckers wasperformed. The results show that in a polarization system, there are a cathode reaction of oxygenabsorption on the surface of the composite and an anode reaction, which is mainly depended on theconcentration of the hydroxyl (OH¯). A slight acceleration of the absorption behavior and thedecrease in the mechanical properties of the CF/VE composite are caused by the galvanic corrosion
    Materialart: Digitale Medien
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/39/transtech_doi~10.4028%252Fwww.scientific.net%252FAMR.11-12.505.pdf
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  • 7
    Digitale Medien
    Digitale Medien
    Apoptosis and p53 gene expression in male reproductive tissues of cadmium exposed rats (1999)
    Springer
    BioMetals 12 (1999), S. 131-139 
    Details
    ISSN: 1572-8773
    Schlagwort(e): cadmium ; apoptosis ; RT-PCR ; p53 gene expression ; testes ; rat
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Chemie und Pharmazie
    Notizen: Abstract Reverse transcription (RT) PCR technique was used to investigate the mechanism of apoptosis induced by Cd and the change of its related genes in testes and prostate of rats. Adult male rats were given a single (s.c.) injection of CdC l2 0, 2.5, 5.0, 10 μmol/kg. 48 h and 72 h after administration of Cd, animals were sacrificed. The results indicated that Cd can induce apoptosis in testes via p53-independent pathway. No apoptosis occurred in prostate in any of the Cd-exposed groups. There was a clearly negative relationship in testes between p53 gene expression and Cd exposure and this dose-response relationship was observed both at 48 h and 72 h. There was a very small increase of this gene expression in the dorsolateral lobe of the prostate in Cd exposed groups. The other apoptosis related gene, bcl-x, was not detectable in either control or Cd-exposed group in testes and dorsal prostate. Although the MT-I gene was expressed in testes or dorsal prostate both in control and exposed groups, no overexpression of MT-I gene was found after administration of Cd . The expression of MT-I in the ventral prostate was not detected in the control group, but a weak expression was found after Cd exposure. Since p53 is a tumo r suppressor gene which can inhibit tumorigenesis, the consequence of a Cd-induced decrease of p53 in testes may have a relation to the known risk of Cd tumorigenesis in this tissue.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1023/A:1009273711068
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  • 8
    Digitale Medien
    Digitale Medien
    Kinetics of Fas-Induced Apoptosis in Thymic Organ Culture (1997)
    Springer
    Journal of clinical immunology 17 (1997), S. 74-84 
    Details
    ISSN: 1573-2592
    Schlagwort(e): Apoptosis ; Fas ligand ; thymic organ culture ; T cells
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Although most thymocytes express high levels of Fas antigen (CD95), the role of Fas in apoptosis signaling during thymocyte maturation has not been defined. Fas apoptosis occurs primarily in the CD4+CD8+ subpopulations of thymocytes. Fas expression and apoptosis function were investigated in the CD4−8−, CD4+8+, and CD4+ and CD8 single positive thymocyte subpopulations by in vivo injection of anti-Fas and in vitro incubation of Fas with thymic organ cultures. Fas was first expressed on CD4−8− thymocytes coincident with expression of IL-2R and CD44. In Fas mutant lpr/lpr mice, defective Fas expression correlated with overproduction of late-stage CD4−8−-thymocytes. Fas was highly expressed on CD3dull and CD3bright thymocytes. CD4+8+CD3dull thymocytes were sensitive to Fas apoptosis, whereas more mature CD4+8+CD3bright thymocytes were resistant to Fas apoptosis. Anti-Fas incubation with established thymic organ culture for 24 hr resulted in apoptosis of approximately 25% of thymocytes. Continued incubation of thymic organ culture with anti-Fas resulted in an apoptosis rate of 25% of CD4+CD8+ thymocytes per day for the first 3 days of culture. Continued culture for further time points up to 6 days did not result in further apoptosis of the CD4+CD8+ thymocytes. These results suggest that CD4−CD8−CD44+ IL-2R+ thymocytes express Fas and there is overpopulation of the subsequent developmental stage of thymocytes in Fas mutant lpr mice. Also, early-stage CD4+8+ thymocytes are susceptible to Fas apoptosis, whereas Fas apoptosis resistance is required after 3 days of thymic organ culture. We conclude that these two populations of thymocytes are susceptible to Fas ligand-mediated apoptosis during T cell development in the thymus.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1023/A:1027392613714
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  • 9
    Digitale Medien
    Digitale Medien
    Chemosensory Orientation of the Rock Crab Cancer irroratus (1999)
    Springer
    Journal of chemical ecology 25 (1999), S. 315-329 
    Details
    ISSN: 1573-1561
    Schlagwort(e): Crustacea ; crabs ; foraging ; chemosensory orientation ; chemoreception ; odor ; vision ; path analysis ; track analysis
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Chemie und Pharmazie
    Notizen: Abstract The importance of chemical cues in the foraging behavior of the rock crab, Cancer irroratus, was investigated. Crabs were presented with mussel prey located upstream, downstream, or cross-stream. Trials were conducted under both light and dark conditions. With the prey upstream, the crabs exhibited the shortest search time and 100% searching success. There was a significant difference between flow direction treatments, but there were no significant differences between light and dark treatments. When presented with mussel extract and a seawater control, crabs approached the source of the current. Analysis of search patterns revealed differences in search time, path length and straightness, and total number of turns. Chemoreception was the predominant mode of prey detection and was used in guiding crabs to their prey. Large variabilities in the search path and search path parameters were exhibited, and there was no fixed search pattern for orientation toward food while foraging. It is suggested that rock crabs employed both chemotaxis and rheotaxis for locating odor sources.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1023/A:1020898830096
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  • 10
    Digitale Medien
    Digitale Medien
    Altered predator/prey behavior in polluted environments: implications for fish conservation (1999)
    Springer
    Environmental biology of fishes 55 (1999), S. 43-51 
    Details
    ISSN: 1573-5133
    Schlagwort(e): contamination ; behavior ; toxicants ; population differences ; prey capture ; predator avoidance ; feeding ; behavioral toxicology
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Abstract Predator/prey behavior has important consequences for individual survival and recruitment into fish populations, both of which can be affected by stressors such as environmental contaminants. The degree to which prey capture or predator avoidance abilities of a predator or prey species are affected will determine the direction in which the balance will be shifted. In a contaminated estuary we have studied, prey capure and predator avoidance of resident mummichogs, Fundulus heteroclitus, are impaired, which may account for individuals in that estuary having reduced growth and longevity compared with those from uncontaminated sites. Exposure to sediments, water, and grass shrimp from the contaminated site can impair the predatory abilities of mummichogs from a clean site. An important prey species, the grass shrimp, Palaemonetes pugio, has a greater population density and a greater proportion of large individuals at the polluted site, apparently because of reduced predation pressure. Mummichog larvae at the polluted site are initially more active and better at prey capture and predator avoidance than larvae from clean sites, but later they become poorer at both. Differences in predator vulnerability among larvae appear to be due to population differences in behavior, which may be due in part to both genetic and environmentally-caused factors. Conservation of fish populations should consider fish behavior and its interaction with contaminants.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1023/A:1007496528012
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