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Continence mechanism of the ileal neobladder in women: a urodynamics study (1998)

Aboseif, Sherif R. ; Borirakchanyavat, Sansern ; Lue, Tom F. ; [et al.]

Springer

World journal of urology 16 (1998), S. 400-404

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ISSN: 1433-8726

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Abstract We undertook this study to evaluate the mechanism of continence in women who underwent modified radical cystectomy and creation of an ileal neobladder. Our surgical technique was modified in accordance with detailed anatomic dissection of female pelvises with attention to the innervation of the pelvic musculature and urethral sphincter. Ten women aged 41–71 years (mean 64.3 years) underwent nerve-sparing radical cystectomy and creation of an orthotopic neobladder with detubularized ileum. Videourodynamic evaluation was performed 6 months postoperatively to evaluate sphincteric and reservoir function. Seven of the ten patients were totally continent after the procedure, requiring no protective pad. Of these, one requires intermittent self-catheterization. Videourodynamic evaluation revealed a low-pressure reservoir with a mean capacity of 467 ml, and leakage did not occur during Valsalva maneuver. Three patients reported significant incontinence (more than one pad per day) after orthotopic reconstruction. These patients demonstrated intrinsic sphincteric deficiency with a low mean abdominal leak-point pressure of 48.3 cmH2O. Two of these women had stress incontinence preoperatively. In conclusion, continence can be preserved in most women after modified radical cystectomy and orthotopic bladder replacement. Success results from preservation of the intrinsic sphincteric mechanism and the creation of a low-pressure, compliant reservoir. A history of stress incontinence preoperatively appears to predispose to sphincteric weakness postoperatively.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/s003450050090

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Analysis of the venom of the sydney funnel-web spider, Atrax robustus using gas chromatography mass spectrometryPFP=pentafluoropropionate; BSTFA = N,O-bis-(trimethylsilyl)trifluoropropionic anhydride. (1979)

Duffield, Patricia H. ; Duffield, Alan M. ; Carroll, Peter R. ; [et al.]

Chichester : Wiley-Blackwell

Biological Mass Spectrometry 6 (1979), S. 105-108

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ISSN: 0306-042X

Keywords: Chemistry ; Analytical Chemistry and Spectroscopy

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Chemistry and Pharmacology

Notes: Thirteen compounds have been identified using gas chromatography mass spectrometry in the venom of the Sydney funnel-web spider, Atrax robustus. The compounds were identified as their trimethylsilyl or pentafluoropropionate derivatives and were citric acid, lactic acid, phosphoric acid, glycerol, urea, glucose, γ-aminobutyric acid, glycine, spermidine, spermidine, tyramine and octopamine. Female venom contained trace quantities of 5-methyoxytryptamine which was not detected in male venom. Quantitative determination of tyramine and octopamine was achieved using chemical ionization (CH4) gas chromatography mass spectrometry and deuterated internal standards.

Additional Material: 4 Ill.