ISSN:
1432-1912
Keywords:
Blood Pressure
;
Guanethidine
;
Nictitating Membrane
;
Reserpine
;
Spleen Strips
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary The pressor action of guanethidine (4 mg/kg) is enhanced by previous administration of reserpine (2 mg/kg), when the time elapsing between the injections of the two drugs is varied between 2 min and 8 hr. This enhancement was observed in the dog (anaesthetized, or spinal or nialamide-pretreated animals) and in the cat. The pressor effects of adrenaline and noradrenaline were not modified by reserpine. Guanethidine caused the nictitating membrane of the dog and the cat, as well as isolated cat spleen strips, to contract and the contractions were enhanced by reserpine; however, the contractions of the nictitating membrane induced by electrical stimulation of the postganglionic sympathetic nerve were not changed by reserpine. Similarly, the pressor effect caused by electrical stimulation of the central end of the vagus nerve was not enhanced. Several mechanisms are discussed in order to explain the observed potentiation; the results are in good agreement with the hypothesis of the existence of different noradrenaline pools.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00997646
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