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  • 1
    Electronic Resource
    Electronic Resource
    Nitric oxide synthesis is decreased in periodontitis (2001)
    Copenhagen : Munksgaard International Publishers
    Journal of clinical periodontology 28 (2001), S. 0 
    Details
    ISSN: 1600-051X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Objectives: In order to study the possible rôle of nitric oxide (NO) in the development of periodontitis, we measured the concentration of its stable metabolite nitrite (NO2−) in the saliva of patients with periodontitis and healthy subjects.〈section xml:id="abs1-2"〉〈title type="main"〉Materials and methods:We have analysed salivary NO2− concentrations in 25 subjects with rapidly progressive periodontitis (RPP), 25 with adult periodontitis (AP) and in 25 periodontally-healthy persons. The concentrations of NO2− were determined by the Griess reaction in microtitration plates. Periodontal tissue destruction was determined by measuring the attachment level loss using standard methods.Results: Subjects with periodontitis had significantly less NO2− in saliva than healthy subjects. Subjects with RPP had lower NO2− concentrations than those with AP. Parotid gland saliva contained less NO2− than sublingual gland or total saliva.Conclusions: Local NO production is decreased in patients with periodontitis. This effect is more pronounced in those with severe types of disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1034/j.1600-051x.2001.028006565.x
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  • 2
    Electronic Resource
    Electronic Resource
    The influence of cyclophosphamide on antitumor immunity in mice bearing late-stage tumors (1993)
    Springer
    Cancer immunology immunotherapy 36 (1993), S. 115-122 
    Details
    ISSN: 1432-0851
    Keywords: Cyclophosphamide ; Tumor immunity ; Suppressor cells
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Spleen cells from mice bearing late-stage methylcholanthrene-induced tumor did not show any tumor activity when mixed with tumor cells in Winn's assay. Treatment of these mice with cyclophosphamide (CY) induced a tumor-inhibitory activity in spleen, occurring on day 7 after treatment, reaching its maximum on day 11 and disappearing by day 21. This antitumor activity could not be induced in control, tumor-free or T-deficient tumor-bearing mice. CY-induced tumor-inhibitory activity was immunologically specific, and mediated by Thy-1+, L3T4−, Ly-2+ cells. Contrary to spleen cells from untreated tumor-bearing mice, spleen cells from CY-treated tumor-bearing mice did not suppress the antitumor activity of immune spleen cells in Winn's assay. However, in contrast to immune spleen cells, CY-induced tumor-inhibitory cells did not manifest antitumor activity when transferred systemically (i. v.) into T-cell-deficient tumor-bearing mice. Even more, spleen cells from CY-pretreated mice, harvested 7–15 days after the drug administration, partially suppressed the antitumor activity of concomitantly transferred spleen cells from specifically immune mice. Nevertheless, CY-pretreated mice manifested concomitant immunity, i.e. these mice exhibited higher resistance to a second inoculum of the same tumor than did nontreated mice or even mice with excised primary tumor.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01754411
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  • 3
    Electronic Resource
    Electronic Resource
    Interference of anti-tumor and immunosuppressive effects of cyclophosphamide in tumor-bearing rats (1982)
    Springer
    Cancer immunology immunotherapy 14 (1982), S. 36-40 
    Details
    ISSN: 1432-0851
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Adult rats were given 105 or 106 Yoshida ascites sarcoma (YAS) cells IP and were treated with cyclophosphamide (CY) given IP in single doses of 20 mg/kg or 100 mg/kg, 2 or 5 days after YAS inoculation. Both the curative effect of CY and subsequent resistance to tumor challenge in rats that survived depended on the dose of injected tumor cells and on the dose and time of administration of CY. These three factors determined whether the host's immune response to tumor antigens would develop and contribute to the overall anti-tumor effects of the chemotherapy. The curative effects of CY were significantly less pronounced in T-cell-deficient than in normal rats. Anti-tumor and immunosuppressive activities of CY exerted opposite influences on the ultimate result of the chemotherapy. Adverse immunosuppressive effects prevailed when the drug was administered early (2 days) after YAS inoculation. In this case the chemotherapy was less efficient and the surviving rats were susceptible to a subsequent tumor challenge. Further analysis showed that the injection of CY 2 days after inoculation of YAS antigens induced strong and specific immunologic tolerance to the tumor. In contrast, when a sufficient amount of tumor antigens (higher dose of tumor cells injected and CY injection delayed) elicited an anti-YAS immune response that was not suppressed by early injection of CY (CY administered 5 days after the tumor) effective eradication of tumor cells and anti-YAS resistance in cured animals were observed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00199430
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  • 4
    Electronic Resource
    Electronic Resource
    Prognostic significance of plasma prostaglandin E concentration in patients with head and neck cancer (1992)
    Springer
    Journal of cancer research and clinical oncology 118 (1992), S. 308-313 
    Details
    ISSN: 1432-1335
    Keywords: Head and neck tumours ; PGE ; Prostaglandins ; Squamous carcinoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Plasma prostaglandin E (PGE) levels were determined by radioimmunoassay in 53 patients with various stages (II, III, and IV) of hypoharyngeal and laryngeal sequamous cell carcinoma, in 12 non-cancer patients and in 10 healthy volunteers. The mean PGE concentration was somewhat higher in non-cancer patients (mean ± SD=34.6±5.37 pg/ml) than in healthy subjects (28.1±4.96 pg/ml). In spite of a high data variability, the mean preoperative PGE levels in cancer patients were proportional to the stage of the disease and higher than in non-cancer patients (41.2±19.7 pg/ml, 52.8±26.7 pg/ml and 82.0±34.9 pg/ml in stages II, III and IV respectively). The mean plasma PGE concentration significantly decreased for all tumour stages 15–30 days after surgical removal of the tumour, but rose again in some patients within 6–18 months after surgery. The incidence of tumour recurrences 6 and 18 months after surgery was significantly higher in patients with an increased preoperative PGE level (〉43.3 pg/ml) than in those patients with a PGE level within the normal range (〈43.3 pg/ml). The mortality was also higher in the former group, but the difference did not reach the level of significance. Similarly, the mean preoperative and most postoperative concentrations of PGE were significantly higher in patients in whom tumour recurred within 18 months than in tumour-free patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01208621
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