ISSN:
1438-8359
Keywords:
Coronary artery
;
Calcium-induced contraction
;
Hypothermia
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract The effects of calcium and temperature on the tension of isolated canine coronary arterial strips were studied. In 20 mEq·l −1 K solution, the tension was significantly increased from 0 mg with 0 mEq·l −1 Ca to 33 ± 18 mg with 0.2 mEq·l −1 Ca at 37°C, from −40 ± 18 mg with 0 mEq·l −1 Ca to −17 ± 11 mg with 0.2 mEq·l −1 Ca at 30°C, from −77 ± 19 mg with 0 mEq·l −1 Ca to −52 ± 17 mEq·l −1 with 1 mEq·l −1 Ca at 25°C, from −88 ± 13 mg with 0 mEq·l −1 Ca to −41 ± 18 mg with 2 mEq·l −1 Ca at 20°C, from −125 ± 16 mg with 0 mEq·l −1 Ca to −116 ± 13 mg with 2 mEq·l −1 Ca at 15°C. Ca higher than 0.2 mEq·l −1 produced a dose-dependent increase in tension between 37°C and 15°C. In spite of the presence of 4 mEq·l −1 Ca, the development of tension was strongly supressed by lowering the temperature below 20°C, and completely inhibited at 10°C. The rate of a decrease in tension caused by cooling was about 5.5 mg·°C−1. This study demonstrated that Ca2+ produced a dose-dependent increase in tension in high-K solution, which was suppressed as the temperature was lowered. (Yoshida K, Fujii Y, Ina H, et al.: Effects of calcium and temperature on tension in isolated canine coronary artery. J Anesth 5: 172–176, 1991)
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s0054010050172
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