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  • 1
    Electronic Resource
    Electronic Resource
    Mechanism of the Vulnerable Period in a Model of Cardiac Fibrillation (1990)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of cardiovascular electrophysiology 1 (1990), S. 0 
    Details
    ISSN: 1540-8167
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Vulnerable Period. The mechanism of the vulnerable period for induction of fibrillation was investigated with a computer model of propagated excitation. The model included nonuniform cycle length dependent refractoriness and slow propagation during incomplete recovery. Recovery properties that permitted induction of fibrillation by a single stimulus were identified, and fibrillation usually occurred after stimuli later than the earliest stimulus resulting in propagation. The responsible mechanism was slow propagation near the stimulus site during excitation from the earliest effective stimulus. The time required for That propagation permitted sufficient recovery in surrounding regions that excitation propagated without reentry. Later stimulation was associated with more rapid propagation near The stimulus site, so surrounding regions were invaded while recovery was markedly nonuniform. This resulted in nonuniform propagation and self sustained reentrant excitation simulating fibrillation. Nonuniformity of premature propagation was quantitated and increased with increasing stimulus cycle length before progressively decreasing. The time of maximal increase of nonuniformity became later with increasing mean value of disparate recovery, but was not affected by The range of disparity. Findings provide a possible explanation for failure of The earliest propagated premature response to initiate fibrillation and suggest That prolonged recovery is associated with vulnerability to late premature responses. (J Cardiovasc Electrophysiol, Vol. l, pp. 303–308, June 1990)
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1540-8167.1990.tb01071.x
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  • 2
    Electronic Resource
    Electronic Resource
    THE PRESENTATION OF SPATIAL VECTORCARDIOGRAPHIC DATA ON A LINEAR TIME SCALE (1957)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 65 (1957), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1957.tb36691.x
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    The Prolonged QT Interval (1979)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Medicine 30 (1979), S. 171-179 
    Details
    ISSN: 0066-4219
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.me.30.020179.001131
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Mechanisms in Simulated Torsade de Pointes (1993)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of cardiovascular electrophysiology 4 (1993), S. 0 
    Details
    ISSN: 1540-8167
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Torsade de Pointes. A mechanism of torsade de pointes consisting of moving sites of reentrant excitation has been proposed on the basis of findings with a computer model. Substantialadditions to that mechanism are now proposed based on further studies with the same model.The model simulated propagation, cycle length-dependent recovery of excitability, and slowpropagation during incomplete recovery. Regions of relatively short and long recovery wereassigned because of evidence of regional prolongation of recovery in long QT syndromes inwhich torsade dc pointes is frequent. As previously reported, premature excitation in the shortrecovery region initially propagated independently, then entered the long recovery region andreentered the short recovery region distal to the site of origin. Reentrant excitation initiated asimilar series of events, and serial reentry at systematically changing locations resulted inchanging patterns of excitation compatible with the changing QRS waveform in torsade depointes. Episodes terminated when reentrant excitation reached the end of unclosed shortrecovery paths, collided in closed paths, or encountered refractoriness in the presence ofnonuniform short recovery. In this study, it was shown that excitation preceding reentry hadimportant effects on the mechanism. These included reversal of the direction of serial reentry, bidirectional serial reentry, reentry at multiple sites from the same parent conditions, andoccurrence of reentry without the requirement of slow propagation. Evidence for a Dopplershift of cycle lengths in regions from which serial reentry was receding or approaching wasobtained. Sustained serial reentry was also demonstrated and is a possible mechanism for polymorphic ventricular tachycardia. Findings further define a possible mechanism of torsade depointes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1540-8167.1993.tb01243.x
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    Paper (German National Licenses)
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