ISSN:
1365-2036
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Medicine
Notes:
Background: Patients with coronary artery disease presenting to an emergency department with chest pain are likely to undergo hospitalization in an attempt to elucidate its aetiology.Aim: To examine whether coronary artery disease patients receiving proton-pump inhibitor therapy are associated with fewer chest pain events and evaluations.Methods: A veteran patient population with documented coronary artery disease was identified, and chest pain episodes, emergency department visits and hospitalizations for chest pain were followed over 2 years. Patient outcomes between proton-pump inhibitor use and non-use of proton-pump inhibitor therapy were compared.Results: In 415 male patients, 23% utilized a proton-pump inhibitor and 77% did not. Proton-pump inhibitor therapy was associated with fewer chest pain episodes (12% vs. 26%, P = 0.002), emergency department visits, (12% vs. 24%, P = 0.044) and hospitalizations (13% vs. 24%, P = 0.086). The incidence of adverse events was decreased in the proton-pump inhibitor group: 70% fewer chest pain episodes (P = 0.002, RR = 3.3), 55% fewer emergency department visits (P = 0.049, RR = 2.2) and 53% fewer hospitalizations (P = 0.064, RR = 2.1). By multivariate analysis, proton-pump inhibitor therapy independently predicted a reduced prevalence of patients experiencing chest pain, emergency department visits, and hospitalizations [OR = 0.09 (0.04–0.21); 0.15 (0.06–0.40); 0.14 (0.05–0.40); all P 〈 0.001].Conclusions: Proton-pump inhibitor therapy for veteran coronary artery disease patients is associated with fewer chest pain episodes, emergency department visits and hospitalizations for chest pain.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1111/j.1365-2036.2005.02511.x
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