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  • 1
    Electronic Resource
    Electronic Resource
    The effect of UV irradiation and photochemotherapy (PUVA) on histamine weal and flare in human skin (1983)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental dermatology 8 (1983), S. 0 
    Details
    ISSN: 1365-2230
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: It is recognized that ultraviolet light has a beneficial effect in various inflammatory disorders of the skin. We have used histamine weal and flare as a model testing the effect of ultraviolet light on vascular response. No difference in weal and flare reaction following intradermal injection of 0·01-10·0 μg of hisiamine was found between covered and exposed skin following UV radiation or photochemotherapy (PUVA).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2230.1983.tb01830.x
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  • 2
    Electronic Resource
    Electronic Resource
    Dowling Club visit to Texas 1982 (1984)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental dermatology 9 (1984), S. 0 
    Details
    ISSN: 1365-2230
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2230.1984.tb00768.x
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Reactivation of cutaneous leishmaniasis after surgery (1999)
    Oxford, UK : Blackwell Science Ltd
    British journal of dermatology 141 (1999), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Cutaneous leishmaniasis (CL) is caused by a parasite from the genus Leishmania. Infection is transmitted to humans from the bite of sandflies. We describe an 85-year-old man who developed CL on his face after recent cutaneous surgery in that site. The case is also unusual because the most likely source of exposure to the infection occurred over 50 years previously. Polymerase chain reaction, slit-skin smear, serology and the leishmanin test were not helpful in diagnosis, which was confirmed by histopathological demonstration of the parasite.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2133.1999.03215.x
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  • 4
    Electronic Resource
    Electronic Resource
    Juvenile Plantar Dermatosis—atopy or footwear? (1986)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental dermatology 11 (1986), S. 0 
    Details
    ISSN: 1365-2230
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Two hundred and fifty patients with Juvenile Plantar Dermatosis (JPD) were studied in relation to the role of atopy and footwear. Two hundred and eighteen affected children were patch-tested to a standard battery of contact allergens and to a range of shoe and sock constituents. Positive patch-tests were found in only 9%. A control group of 172 normal children was also studied. JPD appears to be related to a high incidence of atopy (61%, positive in personal or immediate family history), but a control group of children from a primary school also had a high incidence of atopy. No differences were found in the construction or type of shoe usually worn by affected children and controls.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2230.1986.tb00504.x
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  • 5
    Electronic Resource
    Electronic Resource
    Studies on sweating and bacterial ecology in Juvenile Plantar Dermatosis (1986)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental dermatology 11 (1986), S. 0 
    Details
    ISSN: 1365-2230
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The role of sweating and the surface bacterial flora were studied in 34 patients with Juvenile Plantar Dermatosis (JPD), and in 51 control patients. In 11 patients with JPD the spatial distribution of active sweat ducts was abnormal. Affected areas on the big toes of children with JPD were hypohidrotic and the number of visible sweat duct openings was Reduced, Sweating was studied quantitatively in 26 patients with JPD and 20 normal controls. No increase or decrease in sweat retention could be demonstrated in JPD patients compared to controls.No difference was found in bacterial counts from the plantar surfaces of the big toes in any of three groups—34 JPD Patients, six patients with atopic eczema (with normal feet) and 21 normal controls.It is unlikely that the hypohidrosis seen in affected areas of the feet of patients with JPD is due to miliaria induced by occlusive footwear, but probably is a phenomenon which results from the dermatosis itself.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2230.1986.tb00505.x
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  • 6
    Electronic Resource
    Electronic Resource
    Teaching non-dermatologists to examine the skin: a review of the literature and some recommendations (1995)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 132 (1995), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: An international committee has recently decided on standard definitions of common dermatological terms. However, some inconsistencies remain. Those concerning the definitions of ‘plaque’ and ‘patch’ could be resolved by making the lower limit of size of these lesions 0.5 cm, to correlate with the proposed 0.5 cm upper limit of size of a macule and a papule.The practice of describing crust, scale, etc. as secondary lesions should be abandoned. Instead, the type of lesion (e.g. papule, plaque, nodule), and its surface features (e.g. scale, crust, etc.) should be described separately. The concept of smooth/normal as a surface feature should be included.A scheme is recommended for describing skin lesions, which is based on the following features: (i) their site, distribution and arrangement; (ii) lesion morphology, under the following headings: palpation, type, surface, colour, border, size, shape; and (iii) associated features, such as changes affecting the nails, mouth, scalp and genitals.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1995.tb05017.x
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  • 7
    Electronic Resource
    Electronic Resource
    DERMIS: a computer system for assisting primary-care physicians with dermatological diagnosis (1992)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 127 (1992), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: DERMIS is a computerized skin disease diagnostic prompting system which has been derived from the prospective study of 5205 cases. It has been designed for use by non-dermatologists such as general practitioners. The program produces a list of reasonable diagnoses based on probabilities calculated using Bayes’ theorem. Out of 221 precise diagnoses made by the dermatologist in the clinic, 42 groupings were created to encompass the most common or important diseases encountered in general practice. Four ‘remainder’ or 'send to specialist’ groups were included for the 13% of uncommon conditions. The program, when tested by ‘one out’ analysis on the original cases, placed the correct diagnosis first on 76% of occasions, and within the first three on 95% of occasions. In 76 of 125 cases randomly selected from the data base, a request for diagnostic assistance had been made by the referring general practitioner. It has been estimated that in 54 of these 76 cases the DERMIS system could have provided differential advice with the correct diagnosis appearing at the top of the list.The system has been written in MUMPS and runs on an IBM-compatible desk-top computer. The software allows real time data entry. Arrangements are in hand for performing clinical trials of the system in general practice. If current performance is maintained, and the response to the system's output is favourable, then DERMIS might well enhance performance in medical decision making for the benefit of patients, medical services and budget holders.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1992.tb14875.x
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  • 8
    Electronic Resource
    Electronic Resource
    Anti-androgen treatment in women with acne: a controlled trial (1986)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 114 (1986), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Ninety female patients with acne were allocated randomly to one of three groups and treated either with Diane, a high dose cyproterone acetate (CPA) regime with ethinyloestradiol, or Minovlar. The same dose of oestrogen was common to all three treatment groups.Patients were assessed every 2 months for 6 months, by grading for severity of the acne, lesion counts and photography, and subjectively using a visual analogue scale. In addition, bacteriological sampling and sebum excretion rate (SER) measurements were performed.The results showed a clinical improvement in all three treatment groups, but a more rapid and complete response was seen in those groups who received CPA. There was also a consistent trend suggesting a more favourable response in those in the high dose CPA group. Although there was a marked reduction in SER in the groups treated with CPA, there was no correlation between reduction in SER and clinical improvement in individuals, nor could a reduction in the surface bacterial population be shown to be a primary event in the success of anti-androgen therapy. We have shown that the addition of CPA to oestrogen adds significantly to the therapeutic effect in acne and that anti-androgen and oestrogen combinations are more effective than standard oestrogen and progestagen contraceptive pills.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1986.tb04880.x
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  • 9
    Electronic Resource
    Electronic Resource
    Low-dose oral chloroquine in the treatment of porphyria cutanea tarda (1984)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 111 (1984), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Seven patients with porphyria cutanea tarda received a total of ten courses of low-dose oral chloroquine therapy (125 mg chloroquine phosphate twice weekly). Patients were treated for a mean 14.9 months during which time all went into clinical and biochemical remission. Relapse occurred in four patients on a total of six occasions after a mean 17 months. In four patients there was no relapse after a mean 47·3 months. There were no adverse side-effects from the treatment. Low-dose oral chloroquine therapy appears to be a safe, effective and convenient treatment for porphyria cutanea tarda, although relapses may occur requiring further therapy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1984.tb06632.x
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