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  • 1
    Electronic Resource
    Electronic Resource
    Always more “setrons”: How many do we need? (1997)
    Springer
    Supportive care in cancer 5 (1997), S. 1-2 
    Details
    ISSN: 1433-7339
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01681952
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Interactions of human leukocyte interferon with vinca alkaloids and other chemotherapeutic agents against human tumors in clonogenic assay (1983)
    Springer
    Cancer chemotherapy and pharmacology 10 (1983), S. 161-166 
    Details
    ISSN: 1432-0843
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Purified human leukocyte interferon produced by recombinant techniques (IFN-αA) was tested in vitro with chemotherapeutic drugs, vinblastine (VLB), vincristine (VCR), vindesine (VDS), vinzolidine (VZL), cis-platinum (PLAT), doxorubicin (DOXO), etoposide (VP-16), and melphalan (MEL). The activity of these agents alone or in combination was tested against various human tumor cell lines, using a modified soft agar clonogenic assay. Three human tumor cell lines (myeloma, RPMI 8226; breast, MCF-7; and colon, WiDR) showed sensitivity to these agents at clinically achievable drug concentrations. Statistically significant synergistic activity against in vitro colony formation was observed with the combination of VLB and IFN-αA. An additive or sub-additive effect was usually observed with the other agents tested. Continuous exposure of the 8226 myeloma cell line to both IFN-αA and PLAT showed evidence of a more significant potentiation. It is hypothesized that the synergistic effect observed between VLB and IFN-αA is due to some of their common mechanisms of action.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00255753
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    High-dose dexamethasone for prevention of cis-platin-induced vomiting (1981)
    Springer
    Cancer chemotherapy and pharmacology 7 (1981), S. 11-14 
    Details
    ISSN: 1432-0843
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Severe, debilitating nausea and vomiting are seen in almost 100% of patients treated with cis-platinum. These side-effects can be so severe and prolonged as to preclude therapy in a large number of patients. Commonly used antiemetics have had only limited success in controlling cis-platinum-induced nausea and vomiting. Various reports have indicated benefits from steroids in this setting. We have tested a high-dose dexamethasone regimen with or without neuroleptics, which inhibits chemotherapy-induced vomiting in 50% of patients failing with prior antiemetics and in 71% of those who had not received prior antiemetics. This treatment was administered on an out-patient basis as it involved oral administration of the antiemetic. Neuroleptic therapy was not randomly assigned, but the results of this pilot study suggest that it did not enhance dexamethasone's efficacy. There were no significant side-effects due to the steroids. The antiemetic effectiveness of dexamethasone was retained through repeated courses of chemotherapy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00258206
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Phase I study of cyclohexylamine and lysine salt of mafosfamide (1986)
    Springer
    Cancer chemotherapy and pharmacology 16 (1986), S. 182-183 
    Details
    ISSN: 1432-0843
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Mafosfamide is a new oxazaphosphorine that breaks down spontaneously into 4-hydroxy-cyclophosphamide. A phase I trial with cyclohexylamine and lysine salts of mafosfamide was carried out in 16 patients, using weekly IV perfusion. Dose-limiting toxicities were not hematological, but consisted in the development of severe pain along the vein during administration. A particular mucosal syndrome with sneezing and conjunctivitis was seen only after administration of the lysine salt. The dose of 700 mg/m2 per week represents the maximum tolerated dose with this weekly schedule.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00256173
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  • 5
    Electronic Resource
    Electronic Resource
    An effective five-drug antiemetic combination for prevention of chemotherapy-related nausea and vomiting (1986)
    Springer
    Cancer chemotherapy and pharmacology 16 (1986), S. 282-286 
    Details
    ISSN: 1432-0843
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Antiemetics of known efficacy have been shown to block mainly one of three neurotransmitter receptors in the brain. A combination of antiemetics, designed specifically for outpatient use and consisting of metoclopramide, thiethylperazine, diphenhydramine, dexamethasone, and diazepam, is capable of blocking multiple sites in the emesis pathway. Eighty-four patients receiving highly emetic chemotherapy (85% received cisplatin) completed 200 trials of this five-drug combination using two similar regimens. Complete control (i.e., no nausea or vomiting) was achieved in 45% and two or fewer episodes of vomiting was experienced in 72% of these 200 trials. The mean number of vomiting episodes was 1.65, the median 1.0, and the range 0–15. Sedation was nearly universal, although no serious toxicity was encountered. Thus, this antiemetic combination designed for outpatient use proved highly effective in controlling nausea and vomiting associated with highly emetic anticancer treatment.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00293993
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Corticosteroids, dopamine antagonists and other drugs (1998)
    Springer
    Supportive care in cancer 6 (1998), S. 204-214 
    Details
    ISSN: 1433-7339
    Keywords: Key words Corticosteroids ; Dopamine antagonists ; Canabinoids ; Benzodiazepines
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  The literature on corticosteroids, dopamine antagonists and other antiemetics, such as cannabinoids and benzodiazepines, was reviewed and presented at a consensus conference on antiemetics. Based on the reviews and the discussion during the conference, guidelines for the use of these agents are given.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s005200050155
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  • 7
    Electronic Resource
    Electronic Resource
    Evaluation of the Elderly with Cancer (2000)
    Springer
    Annals of oncology 11 (2000), S. 223-230 
    Details
    ISSN: 1569-8041
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1011156805700
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    Paper (German National Licenses)
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  • 8
    Electronic Resource
    Electronic Resource
    Methodological issues in antiemetic studies (1993)
    Springer
    Investigational new drugs 11 (1993), S. 243-253 
    Details
    ISSN: 1573-0646
    Keywords: antiemetic ; 5-HT3 antagonists ; methodology ; nausea ; emsis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Conclusion In summary, the clinical application of the 5-HT3 antagonists presents new opportunities for the control of the nausea and vomiting associated with cytostatic therapy. If these agents are to be employed at optimal efficacy, both as single agents and in combination, adequately defined doses and schedules (from phase I–II studies) should be investigated in double-blind, randomized and appropriately stratified phase III trials. This is dictated particularly by the subjective nature of nausea and the multi-factorial etiology of nausea and vomiting. Efficacy should be judged according to agreed response criteria for which there is currently no consensus. Response criteria should be based on the patient's experience of both nausea and vomiting, if these are to adequately relate to the patients experience and improve their tolerance of emetogenic therapies. Finally, emphasis should be given to the results after the first 24 hr of acute control of examine the delayed phase, and to assess the results over several cycles of treatment. There is also a lack of data studying the control of anticipatory nausea and vomiting, and new, well designed studies using all the factors described above need to be constructed in these important settings.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00874423
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  • 9
    Electronic Resource
    Electronic Resource
    Sodium azide is less suitable as a positive control of drug-induced lethality for in vitro clonogenic assays (1986)
    Springer
    Investigational new drugs 4 (1986), S. 367-371 
    Details
    ISSN: 1573-0646
    Keywords: sodium azide ; positive control ; in vitro clonogenic assay
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Abstract Sodium azide (6 mg/ml) was used as a positive control for drug-induced lethality in an in vitro clonogenic assay. Petri dishes containing control and sodium azide treated cultures of WiDr cells were placed together in a large Petri dish and incubated at 37°C in an atmosphere of 10% CO2 in air. No growth was observed. Control cells formed colonies only when the dishes were separated from the sodium azide dishes. Using a microtiter plate the toxic effect was inversely related to the distance of the test cultures from the sodium azide treated cultures. These results suggested the formation of a toxic gas or vapour from sodium azide under cell culture conditions, probably an azide. Chemical analysis was based on characteristic reactions, such as the production of a precipitate with silver ions or formation of a red-coloured complex with ferric salts. On a microtiter plate, a gradient of the expected precipitate or red colour was observed, the highest amounts adjacent to the wells containing sodium azide. These results show that sodium azide acts as a positive control of drug-induced lethality for in vitro clonogenic assays. However, the formation of a highly toxic vapour, most likely hydrazaic acid, makes it a less suitable standard.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00173509
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    Paper (German National Licenses)
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  • 10
    Electronic Resource
    Electronic Resource
    Prospective study of left ventricular function using radionuclide scans in patients receiving mitoxantrone (1983)
    Springer
    Investigational new drugs 1 (1983), S. 341-347 
    Details
    ISSN: 1573-0646
    Keywords: mitoxantrone ; dihydroxyanthracenedione ; anticancer drug ; cardiotoxicity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary A prospective Phase II study to evaluate the effects of mitoxantrone on left ventricular ejection fraction (LVEF) has been carried out in patients treated with 12 mg/m2 every three weeks. Gated radionuclide cardiac blood pool imaging with assessment of LVEF and wall motion prior to and during graded exercise was performed before the first and every other mitoxantrone course. Ten patients had either a minor response or tumour stabilization while receiving mitoxantrone treatment and underwent serial radionuclide scans during the course of therapy. Three patients who had received adriamycin as part of prior chemotherapy regimens showed no evidence of cardiotoxicity. Seven patients, who had had no prior adriamycin exposure, underwent serial radionuclide studies while receiving up to 204 mg/m2 of mitoxantrone. None of these patients showed evidence of clinically significant myocardial damage. One had a decline in LVEF from 70% to 50% at a maximum dose of 108 mg/m2. An additional patient whose LVEF rose from 57% at baseline to 62% at a total dose of 204 mg/m2 (17 courses) underwent endomyocardial biopsy which showed grade 2.5 anthracyclinetype cardiotoxicity. Serial endomyocardial biopsy studies are indicated in patients on longterm drug therapy to determine the incidence, dose-relationship and severity of potential mitoxantrone associated endomyocardial damage.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00177420
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