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  • 1
    Electronic Resource
    Electronic Resource
    Scintigraphic detection of gastric and pancreatic carcinomas with In-111 ZCE 025 monoclonal antibody (1991)
    Springer
    World journal of surgery 15 (1991), S. 122-127 
    Details
    ISSN: 1432-2323
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé Nous avons étudié le rôle de l'anticorps monoclonal anti ACE ZCE 025 marqué à l'I-111 chez 8 patients. Trois d'entre eux avaient un diagnostic certain de cancer gastrique. Trois autres avaient un diagnostic certain de cancer du pancréas. Deux autres patients avaient un taux élevé d'antigène carcino-embryonnaire sans qu'on connaisse l'origine du cancer primitif. Chaque patient avait été perfusé avec 10–80 mg de ZCE 025 à l'In-111 (5.5 mCi). Trois à 7 jours après, l'imagerie planaire et SPECT a décelé 9 des 12 localisations tumorales primitives et les 5 localisations métastatiques déjà connues. Ces examens ont également mis en évidence 6 autres localisations jusqu'alors insoupÇonnées. L'imagerie par anticorps monoclonal ZCE 025 à l'In-111 a redressé le bilan préopératoire chez 2 patients et a permis de trouver le cancer primitif chez 2 autres. La scintigraphie avec l'aide des anticorps monoclonaux ZCE 025 à l'In-111 est utile dans l'évaluation des patients ayant un cancer gastrique ou pancréatique. Elle peut influencer la décision chirurgicale chez ces patients.
    Abstract: Resumen Hemos realizado la valoración del papel del anticuerpo monoclonal In-111 anti-CEA ZCE 025 en 8 pacientes. Tres tenían diagnóstico confirmado de carcinoma gástrico y 3 de carcinoma pancreático. Dos pacientes exhibieron nivelés séricos elevados de antigeno carcinoembriónico en ausencia de una neoplasia primaria conocida. Cada paciente recibió 5.5 mCi In-111 ZCE 025 en infusión a dosis de 10–80 mg. Imágenes planares y SPECT tomadas a los 3 y 7 días después de la infusión detectaron 9 de 12 ubicaciones tumorales conocidas y todos los 5 lugares de metástasis previamente identificados. También encontró 6 ubicaciones metastásicas previamente no sospechadas. Las imágenes con In-111 ZCE 025 MoAb cambiaron la evaluación preoperatoria en 50% de los pacientes estudiados y permitió definir el lugar de la afección primaria en otros dos. No se observaron reacciones clinicas ni bioquimicas adversas. La escintigrafía con el anticuerpo monoclonal es un adyuvante Útil en la evaluación de pacientes con carcinoma gástrico o carcinoma pancreático. Puede tener un impacto beneficioso sobre el proceso de decision quirÚrgica.
    Notes: Abstract We have evaluated the role of In-111 anti-CEA (carcinoembryonic antigen) monoclonal antibody ZCE 025 in 8 patients. Three patients had a confirmed diagnosis of gastric carcinoma. Three had a confirmed diagnosis of pancreatic carcinoma. Two patients had elevated serum levels of CEA with no known primary. Each patient received 5.5 mCi In-111 ZCE 025 infused at doses of 10–80 mg. Planar and single photon emission computed tomography (SPECT) imaging at 3 and 7 days after infusion detected 9 of 12 known tumor sites and all 5 of the previously identified sites of metastasis. In-111 ZCE 025 MoAb imaging also found 6 previously unsuspected tumor sites and changed the preoperative evaluation in 50% of the patients studied. It changed the clinical management in 2 patients and established the site of primary involvement in 2 others. There were no clinical or biochemical reactions. In-111 ZCE 025 monoclonal antibody scintigraphy is a useful adjunct in the evaluation of patients with either gastric or pancreatic carcinoma. It may have a beneficial impact on the surgical decision making in these patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01658982
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  • 2
    Electronic Resource
    Electronic Resource
    Results of immunoscintigraphy using a cocktail of radiolabeled monoclonal antibodies in the detection of colorectal cancer (1998)
    Springer
    Annals of surgical oncology 5 (1998), S. 489-494 
    Details
    ISSN: 1534-4681
    Keywords: Colorectal cancer ; Detection ; Cocktail immunoscintigraphy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background: External immunoscintigraphy using a single monoclonal antibody has been employed successfully to localize primary, recurrent, and occult colorectal carcinoma. This prospective study investigated the accuracy and sensitivity of external immunoscintigraphy when the combination or “cocktail” of radiolabeled monoclonal antibodies, CYT-103 (an IgG1a) and CYT-372 (an IgG2b) directed against TAG-72 and CEA, respectively, is given to patients with known or suspected colorectal cancer. Methods: Eleven patients enrolled in this open label phase I/II study underwent preoperative external immunoscintigraphy after intravenous cocktail administration of two indium 111-labeled monoclonal antibodies (MoAb), CYT103 and CYT372. Antibody dose ranged from 0.2 mg (five patients) to 1.0 mg (six patients), each antibody radiolabeled with 2.5 mCi of indium 111, delivering a total dose of 5 mCi per patient. Planar and SPECT images were performed 2 to 5 days postinjection. Suspected lesions were surgically resected within 2 weeks of injection. Results: A total of 23 lesions (sites) were identified in the eleven patients, 19 of which were confirmed by pathology (hematoxylin and eosin [H&E]). Cocktail immunoscintigrams identified 16 of the 19 confirmed lesions. Computed tomography (CT) scan detected 9 of the 19 lesions. The sensitivities of cocktail immunoscintigraphy and CT scan for the detection of colorectal cancer were 84% and 64%, respectively. The positive predictive value for immunoscintigraphy was 94%. The antibody scans detected six occult, previously unsuspected lesions. Cocktail immunoscintigraphy changed the surgical management in four of the 11 (36%) patients. Conclusions: The combination of In 111 CYT-103 and CYT-372 improved the sensitivity of external immunoscintigraphy for the detection of colorectal cancer compared to that obtained with a single MoAb imaging. Cocktail antibody imaging may enhance the staging and management of patients with cancers of colon and rectum.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02303640
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  • 3
    Electronic Resource
    Electronic Resource
    Immunoscintigraphy with111 In-satumomab pendetide in patients with colorectal adenocarcinoma: Performance and impact on clinical management (1994)
    Springer
    Diseases of the colon & rectum 37 (1994), S. 129-137 
    Details
    ISSN: 1530-0358
    Keywords: 111 In-satumomab pendetide ; Antibody imaging ; Colorectal carcinoma ; Patient management ; Immunoscintigraphy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract PURPOSE: The role of immunoscintigraphy with111 Insatumomab pendetide in the medical and/or surgical management of colorectal cancer patients was evaluated in a multicenter trial. METHODS: This 103 patient study population included 46 individuals with rising serum carcinoembryonic antigen levels and otherwise negative diagnostic evaluation, 29 patients with known recurrence, presumed to be isolated and resectable, and 28 patients for whom standard diagnostic tests provided equivocal information. RESULTS: No adverse reactions were noted following intravenous administration of 1 mg of satumomab pendetide radiolabeled with approximately 5 mCi of111 In. Thirty percent of patients developed human anti-mouse antibodies postinfusion. In the 84 patients for whom correlation with histopathologic, diagnostic, and/or clinical findings was available, antibody imaging demonstrated a sensitivity of 73 percent in patients with confirmed tumor (36/49) and negative results for all 35 patients with no evidence of malignancy. Occult disease was detected in 18 patients. CONCLUSION: 111 In-satumomab pendetide immunoscintigraphy was helpful in the medical and/or surgical management of 45 (44 percent) patients and provided information unavailable from other diagnostic modalities.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02047534
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  • 4
    Electronic Resource
    Electronic Resource
    Imaging strategies in hepatic metastases from colorectal carcinoma (1995)
    Springer
    Journal of hepato-biliary-pancreatic surgery 2 (1995), S. 126-133 
    Details
    ISSN: 1436-0691
    Keywords: imaging ; liver ; metastases ; colorectal cancer
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Approximately two-thirds of metastatic lesions that develop following curative resection of colorectal cancer occur in the liver and lung. In select groups of patients, resection of these lesions is associated with increased 5-year survival. In the liver, precise preoperative documentation of the presence, location, number, and relationship of these lesions to vascular structure is crucial in the selection of candidates for curative resection. Computed tomography with arterial portography (CTAP), intraoperative ultrasonography (IOUS), positron emission tomographic (PET) scan, and radionuclide scanning, including radiolabeled monoclonal antibody imaging, are emerging as the procedures of choice in the preoperative and intraoperative evaluation of metastatic colorectal cancer to the liver.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02348737
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  • 5
    Electronic Resource
    Electronic Resource
    Clinical experience with intra lymphatic administration of111In-labelled monoclonal antibody PAY 276 for the detection of pelvic nodal metastases in prostatic carcinoma (1990)
    Springer
    European journal of nuclear medicine 16 (1990), S. 149-156 
    Details
    ISSN: 1619-7089
    Keywords: Anti prostatic acid phosphatase ; Monoclonal antibody ; Intra lymphatic ; PAY 276 ; 111In
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The ability of111In-PAY 276 (anti prostatic acid phosphatase antibody) in detecting pelvic lymph node metastasis following bipedal intra lymphatic administration was studied in five patients with carcinoma of the prostate. The labeled antibody was injected directly into the lymphatics of each foot. Planar and tomographic images radioactivity content of lymph nodes resected during staging pelvic lymphadenectomy were compared to the histologic and immunoperoxidase findings. Radioactivity in pelvic lymph nodes was prominently seen within 20 min of injection and was present 16 days later. Persistent accumulation of tracer in the lymphatics of the lower extremities was also observed in all patients 16 days post injection. Radioactivity counts in tumor-free lymph nodes were higher than in tumored lymph nodes resected. Our results demonstrate that intra lymphatic administration of111In-labeled PAY 276 monoclonal antibody has major technical limitations, and that further research directed at the causes of tracer accumulation in the lymphatics and tumor-free lymph nodes is required.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01146853
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