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  • 1
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 105 (1998), S. 0 
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Objective To assess the feasibility of collecting disease-specific and generic data on the impact of surgery on the social lives of women with stress incontinence; to describe the social impact of surgery in a representative group; and to determine the effect of timing on the assessment of outcome.Design Longitudinal study; questionnaires before and three, six, and twelve months after surgery.Setting Eighteen hospitals in North Thames region.Participants Four hundred and forty-two women undergoing surgery for stress incontinence between January 1993 and June 1994.Main outcome measures Post-operative recovery time, stress incontinence symptom impact index, activities of daily living, and cost of protection.Results Post-operative recovery was uneventful for most women, but three months after surgery 24% of those in paid employment beforehand were still on sick or unpaid leave. Most women (75%) reported that stress incontinence had less adverse impact on their lives three months after surgery, though 18% reported no change, and 7% felt life was worse. The likelihood of improvement was similar regardless of whether pre-operative urodynamic studies had been conducted. The extent of improvement was dependent on pre-operative severity. Similar findings were obtained six and twelve months after surgery. After an initial slight but nonsignificant deterioration in their ability to carry out activities of daily living, women gained a slight benefit from surgery (proportion with no or only slight limitation rose from 72% to 82%; P= 0.0001). The mean cost of protection (pads and towels) fell from £8.59 a month before surgery to £2.99 a month one year after surgery, by which time 68% of women were not using protection. In contrast, 11% were still spending over £10 a month.Conclusions It is possible to collect standard data on the impact of surgery on social functioning and, thus, provide women with better information on likely outcomes. The benefits of pre-operative urodynamic investigations need to be assessed. The stability of the outcome measures over the first post-operative year suggest that outcomes need to be assessed only once and at any time from three to twelve months after the operation.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Journal of fish biology 6 (1974), S. 0 
    ISSN: 1095-8649
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: Synthetic detergents are reported to be acutely toxic to fish in concentrations between 0.4 and 40 mg/1. Factors affecting toxicity include the molecular structure of the detergent, water hardness, temperature and dissolved oxygen concentration; the age and species of the test fish, and acclimation to low concentrations of detergent. Some of these factors appear to be of only limited importance. Gill damage is the most obvious acute toxic effect; the immediate cause of death may be asphyxiation, but detergents may also be toxic internally. Lethal effects not related to gill damage have not been investigated. Sublethal effects include retardation of growth, alteration of feeding behaviour and inhibition of chemoreceptor organs. Low levels of detergents may also increase the uptake of other pollutants. Invertebrates, especially in their juvenile stages, are extremely sensitive to detergents: concentrations below 0.1 mg/1 interfere with growth and development in some species. The interactions between detergents and proteins, and their influence on membrane permeability may be the basis of the biological action of detergents. Detergents in natural waters are usually partially degraded, and a maximum permissible concentration of 0.5 mg/1 would probably be harmless under most conditions.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Freshwater biology 8 (1978), S. 0 
    ISSN: 1365-2427
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: SUMMARY. Histological and electron microscopical study of the gills of fish poisoned by the anionic detergent sodium lauryl sulphate indicates that the nature of the toxic action changes at a concentration of about 120 mg I−1. Toxicity tests were conducted to determine whether this change could be detected in the test data, using brown trout (Salmo trutta) and rainbow trout (S. gairdneri).Toxicity curves showed no indication of the change in toxic action, but at concentrations of 120 and 130 mg I−1 of sodium lauryl sulphate ‘split’ probit lines occurred, and the lines for 150 mg I−1 consistently differed in slope from other lines.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Freshwater biology 10 (1980), S. 0 
    ISSN: 1365-2427
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: SUMMARY. The acute toxicity of the pesticide γ-hexachlorocyclohexane (Lindane) to Gammarus pulex was determined by a standard procedure and by a modification of the conventional toxicity test protocol. Animals were exposed to a range of concentrations for various periods of time from 1 to 1000 min and transferred to clean water. Animals continued to die for up to 3 weeks after the initial exposure to the poison. Toxicity curves were obtained expressing the relationships between concentration of poison and median survival time (LT50) and between concentration of poison and median lethal exposure time, i.e., the duration of exposure required to cause the eventual death of half the animals. For a given concentration of pesticide, the duration of exposure which will cause 50% mortality is far less than is indicated by a conventional toxicity test in which animals are continuously exposed to the poison. It is suggested that the results of conventional acute lethal toxicity tests may have limited predictive value even when applied to field situations involving the discharge of lethal levels of pollutants to receiving waters.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Journal of fish biology 9 (1976), S. 0 
    ISSN: 1095-8649
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: The pathological effects often lethal concentrations of the anionic detergent, sodium lauryl sulphate, on the gills of Salmo trutta L. have been studied by light and electron microscopy. At concentrations to 120 mg/1 (medium survival times 〉1 h), epithelial cell death is associated with lysosome formation. Acute inflammation of the gill tissue, extensive detachment of the epithelium and, except at the lowest concentrations, collapse of the pillar cell system occur. At concentrations above 120 mg/1 (medium survival times 〈1 h) very rapid lysis of cells results in the complete disruption of cellular and tissue structure. Changes in the gross structure of the gills are explainable in terms of the rate and nature of toxic action at the cellular level. Review of the biomedical literature suggests the observed effects of sodium lauryl sulphate on gill cells correspond to the two mechanisms by which detergents cause death in isolated cells. These are autolysis, i.e. lysis by the action of the cell's own enzymes, induced by an initial lesion in the cell membrane whose precise nature is not known; and rapid lysis by the direct action of the detergent on the cell constituents.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Journal of fish biology 23 (1983), S. 0 
    ISSN: 1095-8649
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: A comparative study of the signs of lindane poisoning and of hypoxia in trout, Salmo trutta L., showed that the symptoms of both causes of death are similar. The rapid fading of gill colour within 2 h of death is characteristic of both treatments and distinguishes these from other causes of death. Vascular congestion and cellular damage of the liver is common to both treatments. The causes of death may be distinguished by the behaviour of the fish before death and by study of their effects on the gills. Hypoxic fish showed increased ventilatory activity, but other activity decreased. Exposure to lethal levels of lindane caused hyperactivity, convulsions, ataxia and intermittent paralysis. Although gill damage in both cases was slight it was distinctive. Lindane caused disarray of the secondary lamellae, and exposure to low dissolved oxygen levels caused breaks in the lamellar epithelium. This was only clearly visible under electron microscopical examination.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Bulletin of environmental contamination and toxicology 41 (1988), S. 404-411 
    ISSN: 1432-0800
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Medicine
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Bulletin of environmental contamination and toxicology 37 (1986), S. 382-386 
    ISSN: 1432-0800
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Medicine
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1434-0879
    Keywords: Lectins ; Carbohydrates ; Non-malignant prostate
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Non-neoplastic prostatic epithelium from 39 patients obtained at transurethral resection for outflow tract obstruction and 5 normal prostates from men under 35 years of age obtained at postmortem were formalinfixed and paraffin-embedded. The distribution of 8 lectin receptors were studied using a peroxidase anti-peroxidase method and an avidin-biotin method. Con A, WGA, and PNA bound to most epithelial cells. Con A,and WGA also showed major stromal binding. Approximately 5% to 10% of cells bound UEA1, GS1, DBA, and BPA. No major differences in lectin receptor expression were observed between normal and hyperplastic epithelium with either of the immunohistochemical techniques except that hyperplastic cells stained more strongly than normal epithelium.
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1434-0879
    Keywords: Lectins ; Glycoconjugates ; Rat prostate
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Normal prostates from Copenhagen/Fischer F1 hybrid rats were removed at 14 months of age. After routine formalin fixation and paraffin embedding, the expression of seven oligosaccharide structures by prostatic epithelial cells was assessed by an examination of lectin binding sites before and after neuraminidase digestion. Con-A bound to plasma membranes as well as the cytoplasm of all cells, thus confirming the presence of complex-type glycoconjugates. However, only two other oligosaccharides, apart from Con-A, were freely expressed on epithelial luminal plasma membranes. These were the Type I structure (Ga1β1→3GalNAc-) identified by PNA-binding and (GlcNAcβ1→4GlcNAcβ1→4-)n identified by WGA. PNA, WGA, UEA-1 and SBA bound to the cytoplasm of almost all epithelial cells, although their intracellular distribution was not identical. DBF binding was not identified. ECG bound to only a very few cells and then only after digestion with neuraminidase when it was localised to the cytoplasm. Following removal of sialic acid groups by neuraminidase digestion, PNA-binding became more prominent, SBA-binding appeared localized to paranuclear intracellular vesicles and WGA binding sites were abolished. This study has now characterized the major oligosaccharide determinants expressed by rat normal prostatic epithelial cells and provides a baseline against which alterations occurring during ontogenesis and oncogenesis may be compared.
    Type of Medium: Electronic Resource
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