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  • 1
    Electronic Resource
    Electronic Resource
    Quantitative methods in nursing research (1996)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of advanced nursing 23 (1996), S. 0 
    Details
    ISSN: 1365-2648
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: This paper considers some of the general principles that are common to much of quantitative research in nursing In particular, the role of hypothesis testing is considered, and the use of estimation is emphasized Confidence intervals are advocated as a means of assessing both statistical and clinical significance These principles and methods are illustrated using examples taken from the nursing literature Finally, more complicated situations and the role of design are discussed
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2648.1996.09121.x
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    The beneficial effects of oral nifedipine on cyclosporin-treated renal transplant recipients — a randomised prospective study (1996)
    Springer
    Transplant international 9 (1996), S. 115-125 
    Details
    ISSN: 1432-2277
    Keywords: Nifedipine, CyA, renal transplantation ; CyA, nifedipine, renal transplantation ; Renal transplantation, nifedipine, CyA
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The aim of this study was to test the hypothesis that nifedipine will improve graft survival in cyclosporin A (CyA)-treated renal transplant recipients. One hundred and forty-seven patients were randomised to one of three regimens. Group A received CyA, 7 mg/kg per day, and prednisolone; group B followed the same regimen as group A plus oral nifedipine and group C received CyA, 4 mg/kg per day, prednisolone and azathioprine. Calcium channel blockers were avoided in groups A and C. The crude 2-year (P=0.0223) and 4-year (P=0.0181) graft survival was significantly better in group B (86% and 81%, respectively) than in group A (75% and 63%, respectively). Delayed initial function was seen least frequently in group B (10.2%) compared to groups A (31%) and C (28%; P〈0.01). Group B also experienced fewer rejection episodes than groups A and C (P〈0.05). We conclude that the combination of oral nifedipine and CyA significantly improves initial graft function, rejection frequency and long term graft survival.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00336388
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    A Bayesian approach to Weibull survival models—Application to a cancer clinical trial (1996)
    Springer
    Lifetime data analysis 2 (1996), S. 159-174 
    Details
    ISSN: 1572-9249
    Keywords: Neutron therapy ; Bayesian inference ; parametric proportional hazards ; exponential distribution ; Weibull distribution ; Laplace approximations
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Notes: Abstract In this paper we outline a class of fully parametric proportional hazards models, in which the baseline hazard is assumed to be a power transform of the time scale, corresponding to assuming that survival times follow a Weibull distribution. Such a class of models allows for the possibility of time varying hazard rates, but assumes a constant hazard ratio. We outline how Bayesian inference proceeds for such a class of models using asymptotic approximations which require only the ability to maximize the joint log posterior density. We apply these models to a clinical trial to assess the efficacy of neutron therapy compared to conventional treatment for patients with tumors of the pelvic region. In this trial there was prior information about the log hazard ratio both in terms of elicited clinical beliefs and the results of previous studies. Finally, we consider a number of extensions to this class of models, in particular the use of alternative baseline functions, and the extension to multi-state data.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00128573
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    Paper (German National Licenses)
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