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  • 1
    ISSN: 1432-1238
    Keywords: Acute severe asthma ; Bronchodilators ; β2 agonists
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Objective To compare efficacy and safety of nebulisation of adrenaline (2 mg over 10 min) and salbutamol (5 mg over 10 min) in acute severe asthma. Design Prospective randomized and double blind study. Setting Intensive care unit of a University teaching hospital. Patients and participants 22 asthmatic patients presenting to the emergency room with acute severe asthma. Interventions Patients were randomly assigned to receive either adrenaline (n=11) or salbutamol (n=11) via a nebulizer. Additional treatment comprised hydrocortisone hemisuccinate (100 mg) and supplemental oxygen (7l/min). The efficacy and safety of both drugs were evaluated at 20 and 40 min. Results A statistically significant increase in the Peak Expiratory Flow (PEF) was achieved at the 20th min in both groups (from 85±38 l/min to 120±45 l/min;p〈0.001; and from 107±28 l/min to 145±19 l/min;p〈0.001; in adrenaline group and salbutamol group respectively). With both drugs, PEF further increased at 40 min to a level that was statistically significant when compared to the 20 min evaluation. The magnitude of the absolute variation in PEF was similar with both drugs. Both drugs induced a significant decrease in heart rate, respiratory frequency and PaCO2 while the increase of PaO2/FIO2 ratio was not significant. The decrease of respiratory frequency at 40 min was more important with salbutamol (p=0.03). No side effects were recorded in both groups. Conclusion After a single dose, nebulized adrenaline (2 mg) proved as effective and safe as salbutamol (5 mg) in acute severe asthma.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-1238
    Keywords: Scorpion envenomation ; Pulmonary edema ; Left ventricular function
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Objective To assess left ventricular function in patients presenting with pulmonary edema following scorpion envenomation. Design Cohort study.Setting: Medical intensive care unit of a teaching hospital.Patients: Nine consecutive adult patients stung byAndroctonus australis and presenting with pulmonary edema entered the study. Fourteen normal volunteers comprised the control group. Interventions Upon admission, all patients had right heart catheterization and, within the first 8 h, a Doppler echocardiographic study. Results of Doppler echocardiographic studies were compared to those of controls. Measurements and results Usual hemodynamic information (heart and vascular pressures, derived data and tissue oxygenation parameters), left ventricular dimensions and indicators of systolic function, and Doppler-derived parameters of left ventricular filling and diastolic function were obtained upon admission. Serial echocardiographic measurements were repeated daily until full clinical recovery (eight patients) or death (one patient). All patients had a hemodynamic profile of acute congestive heart failure (mean PAOP=24±2 mmHg; mean SVI=22±7 ml/m2; mean CI=2.5±0.5 l/min/m2). However, SVR were not increased (mean=22±3 U/m2). Left ventricle was hypokinetic in all patients with transient mitral regurgitation present in five patients. Left ventricular systolic function was markedly depressed (FS=12±6%; EF=26±12%). An associated diastolic dysfunction is suggested by Doppler records of mitral inflow. Left ventricular systolic function evolved toward normalization within 6±2 days preceded by full clinical recovery. Conclusions These data suggest that pulmonary edema in scorpion envenomation is of hemodynamic origin and is related to a severe and prominent impairment of left ventricular systolic function.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1432-1238
    Keywords: Key words Weaning ; Mechanical ventilation ; Balloon mitral commissurotomy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Successful weaning from mechanical ventilation (MV) following percutaneous balloon mitral commissurotomy (BMC) is reported in a 59-year-old woman with severe symptomatic rheumatic mitral stenosis. The patient was admitted to the Intensive Care Unit for acute respiratory failure secondary to pulmonary edema requiring intubation and mechanical ventilation. After resolution of the acute phase, she became completely dependent on mechanical ventilatory support. In spite of the reinforcement of conventional therapy (diuretics, digitalis, vasodilators), weaning attempts were unsuccessful because of persisting elevated left atrial pressure. Percutaneous BMC was performed with favorable hemodynamic results, allowing the removal of external ventilatory support 24 h later and discharge from the Intensive Care Unit the same day.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1432-1238
    Keywords: Key words Simplified Acute Physiology Score ; Omega system ; Severity of illness index ; Workload ; Outcome assessment ; Intensive care unit comparison ; Cost-effectiveness analysis ; Evaluation studies ; Organization ; Quality of care
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Objectives: To compare the variations in intensive care (ICU) outcome in relation to variations in resources utilization and costs between a developed and a developing country with different medical and economical conditions. Design and setting: Prospective comparison between a 26-bed French ICU and an 8-bed Tunisian ICU, both in university hospitals. Patients: Four hundred thirty and 534 consecutive admissions, respectively, in the French and Tunisian ICUs. Measurements: We prospectively recorded demographic, physiologic, and treatment information for all patients, and collected data on the two ICU structures and facilities. Costs and ICU outcome were compared in the overall population, in three groups of severity indexes and among selected diagnostic groups. Results: Tunisian patients were significantly younger, were in better health previously and were less severely ill at ICU admission (p 〈 0.01). French patients had a lower overall mortality rate (17.2 vs 22.5 %; p 〈 0.01) and received more treatment (p 〈 0.01). In the low severity range, the outcome and costs were similar in the two countries. In the highest severity range, Tunisian and French patients had similar mortality rates, while the former received less therapy throughout their ICU stays (p 〈 0.05). Conversely, in the mid-range of severity, mortality was higher among Tunisian patients, and a difference in management was identified in COPD patients. Conclusion: Although the Tunisian ICU might appear more cost-effective than the French one in the highest severity group of patients, most of this difference appeared in relation to shorter lengths of ICU stay, and a poorer efficiency and cost-effectiveness was suggested in the mid-range severity group. Differences in economical constraints may partly explain differences in ICU performances. These results indicate where resource allocation could be directed to improve the efficiency of ICU care.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1432-1238
    Keywords: Pre-eclampsia ; Hellp syndrome ; Perinatal outcome
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Objective: to determine the incidence of Hellp syndrome (HS) and the maternal fetal outcome associated with its occurrence.Design: a prospective study during a 6-month period.Setting: the department of obstetrics and gynecology and the Intensive Care Unit of a 700 bed teaching hospital.Patients: Sixty-two consecutive preeclamptic and eclamptic women.Measurements and results: all patients were systematically investigated for the biological markers of HS. The effects of the occurrence of HS on maternal and fetal prognosis were evaluated by comparing for prognosis indicators usually assessed in gravidic hypertension, pre-eclamptic and eclamptic women who exhibited HS (HS+subgroup) with HS free patients (HS-subgroup). HS was found in 12 out of the 62 pre-eclamptic and eclamptic women (19.3%). Its occurrence was associated with higher maternal mortality (16.7% vs 0%;p=0.03), a greater incidence of eclamptic crisis (50% vs 20%;p=0.03), severe hypertension (33% vs 8%;p=0.03) and episodes of acute renal failure (66% vs 30%;p=0.02). Mean proteinuria was also higher in HS+patients (4.6±3.3 vs 2.2±2.5 g/day;p=0.001). However, fetal outcome was not significantly altered.Conclusion: Pre-eclampsia and elampsia may be more severe in the presence of HS with a worsening of maternal prognosis while fetal outcome seems not altered.
    Type of Medium: Electronic Resource
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