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  • 1
    Electronic Resource
    Electronic Resource
    Picric acid-formaldehyde fixation for immunoferritin studies (1974)
    Springer
    Histochemistry and cell biology 42 (1974), S. 257-264 
    Details
    ISSN: 1432-119X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Picric acid-formaldehyde (PAF) fixative has been compared to other fixatives commonly employed in electron microscopy in order to check its ability to be used in immunoferritin studies. From the results obtained PAF seems to offer very good preservation of the tissue fine structure together with satisfactory detection of immune reactions at ultrastructural level.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00492658
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Deposition of circulating antigen-antibody complexes in the gastrointestinal tract of rabbits with chronic serum sickness (1978)
    Springer
    Digestive diseases and sciences 23 (1978), S. 1098-1106 
    Details
    ISSN: 1573-2568
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The possible role of circulating immune complexes (IC) in the production of gastrointestinal lesions was studied in rabbits with chronic serum sickness (CSS) induced by multiple daily injections of bovine serum albumin (BSA). All rabbits generating a marked antibody response developed IC glomerulonephritis. In approximately 50% of these rabbits granular deposits of BSA, rabbit IgG, and C 3 were also found in the gastrointestinal tract. The immune deposits in the gastrointestinal tract were mainly present in the vessel walls, close to the intestinal glands and the surface epithelium, and between the smooth muscle cells. This was accompanied by slight to moderate edema of the mucosa and the submucosa and mild infiltration of inflammatory cells. Electron-dense deposits were found in a pattern corresponding to that observed for BSA, rabbit IgG, and C 3 . Degranulated neutrophils, basophils, and mast cells were noticed in the interstitium. The presence in the same areas of granular deposits of BSA, IgG, and C 3 , corresponding to electron-dense deposits, suggests that the deposits contain BSA-anti-BSA complexes. These findings show that in rabbits with CSS circulating IC may localize and induce injury in the gastrointestinal tract.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01072885
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Immunoelectron microscopic evidence of contractile proteins in the cellular and acellular components of mouse kidney glomeruli (1975)
    Springer
    Cell & tissue research 162 (1975), S. 297-312 
    Details
    ISSN: 1432-0878
    Keywords: Kidney ; Glomerulus ; Contractile proteins ; Immunoelectron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Actin and/or actin-like protein have been localized in the cellular and acellular components of the glomerular walls of mouse kidney by means of immunoelectron microscopy, employing human antibodies to smooth muscle (SMA). Contractile antigens have been confirmed to be present in the cytoplasm of podocytes and mesangial cells in association with fine filaments which are considered of importance in the control of blood flow, intravascular pressure, and filtration rate within the glomerulus. The extracellular presence of contractile proteins in the mesangial matrix and glomerular basement membrane can be related to cell movement in a frictional environment. This latter phenomenon, which is strictly interdependent with cell adhesion and aggregation, is most evident in the mesangial cells in a form of luminar pseudopodia, cytoplasmic projections, and phagocytosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00220176
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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