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  • 1
    Electronic Resource
    Electronic Resource
    Determination of eproxindine hydrochloride in human plasma by capillary gas chromatography
    Amsterdam : Elsevier
    Journal of Chromatography B: Biomedical Sciences and Applications 427 (1988), S. 157-161 
    Details
    ISSN: 0378-4347
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0378-4347(88)80115-4
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  • 2
    Electronic Resource
    Electronic Resource
    Determination of timelotem dihydrogenmaleate and its main metabolite N-desmethyltimelotem in plasma by capillary gas chromatography
    Amsterdam : Elsevier
    Journal of Chromatography B: Biomedical Sciences and Applications 419 (1987), S. 357-362 
    Details
    ISSN: 0378-4347
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0378-4347(87)80300-6
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  • 3
    Electronic Resource
    Electronic Resource
    Determination of revenast hydrochloride in human plasma by gas chromatography with nitrogen-selective detection
    Amsterdam : Elsevier
    Journal of Chromatography B: Biomedical Sciences and Applications 419 (1987), S. 351-356 
    Details
    ISSN: 0378-4347
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0378-4347(87)80299-2
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  • 4
    Electronic Resource
    Electronic Resource
    Inhibition of monocyte and polymorphonuclear granulocyte immune phagocytosis by monoclonal antibodies specific for FcγRI, II and III (1997)
    Springer
    Annals of hematology 74 (1997), S. 15-22 
    Details
    ISSN: 1432-0584
    Keywords: Key words mAb ; CD64 ; CD32 ; CD16 ; FcγRIIa HR ; FcγRIIa LR
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  We tested two Fcγ receptor I (FcγRI); six FcγRII; and six FcγRIII-specific monoclonal antibodies (mAb) for their capacitiy to inhibit monocyte and polymorphonuclear granulocyte (PMN) immune phagocytosis which is mediated by FcγR. We used human red blood cells (rbc) coated with hIgG1 or mIgG1 as FcγRI- and FcγRII-specific target cells, respectively. The FcγRI-specific mAbs 22.2 and 32.2 did not inhibit FcγRI- or FcγRII-specific monocyte immune phagocytosis. The FcγRII-specific mAbs IV.3, CIKM5, FLI8.2, FLI 8.26, 2E1, and 41H16 inhibited FcγRII-specific monocyte immune phagocytosis in all FcγRIIa high-responder (HR) individuals but did not inhibit FcγRI-specific phagocytosis. Using PMN, FLI8.2 and 2E1 only partially inhibited phagocytosis in HR individuals, but the FcγRIII-specific mAbs 3G8, DJ130c, MFM-154, B88-9 and MG38 completely inhibited FcγRII-specific phagocytosis if the corresponding antigen was available on the cell surface. In these cases phagocytosis inhibition may be explained by cross-linking of FcγRII and FcγRIII via one antibody molecule, with the Fab portion binding to FcγRIII and the Fc portion binding to FcγRII.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002770050249
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  • 5
    Electronic Resource
    Electronic Resource
    Pharmacokinetics of N-propylajmaline in relation to polymorphic sparteine oxidation (1985)
    Springer
    Journal of molecular medicine 63 (1985), S. 1180-1186 
    Details
    ISSN: 1432-1440
    Keywords: N-propylajmaline ; Pharmacokinetics ; Genetic polymorphism ; Sparteine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In order to determine whether the metabolism of the antiarrhythmic drug N-propylajmaline is under the same genetic control as sparteine metabolism, the pharmacokinetics of this antiarrhythmic drug were studied in a group of six extensive and four poor metabolizers of sparteine. Pronounced differences in terminal half-life, total plasma clearance, metabolic clearance and urinary excretion of N-propylajmaline were observed between extensive and poor metabolizers. A close relationship between the total clearance and metabolic clearance of N-propylajmaline and sparteine could be demonstrated. Clinically available N-propylajmaline is a 55% to 45% mixture of thei-andn-diastereomers. The extensive metabolizers exhibited stereoselective metabolism; thei-diastereomer was preferentially metabolized. Poor metabolizers were characterized by a loss of this stereoselective metabolism. Five subjects were treated for 7 days with a daily N-propylajmaline dosage of either 60 mg or 20 mg. Since a close relationship between the clearance of N-propylajmaline and the metabolic ratio of sparteine had been observed after single dosing the metabolic ratio of sparteine was used to predict N-propylajmaline steady-state plasma concentrations during multiple dosing. Only in two extensive metabolizers with a metabolic ratio 〈0.4 predicted and observed, steady-state plasma concentrations were in good agreement. In the other three subjects observed steady-state plasma concentrations were appreciably higher than predicted. In these three subjects metabolic N-propylajmaline clearance decreased indicating saturation of N-propylajmaline metabolism during multiple dosing. The data indicate that N-propylajmaline metabolism is subject to a genetic polymorphism controlled by the sparteine/debrisoquine gene locus.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01740595
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  • 6
    Electronic Resource
    Electronic Resource
    The NA"null" phenotype of a young man is caused by an FcγRIIIB gene deficiency while the products of the neighboring FcγRIIA and FcγRIIIA genes are present (1998)
    Springer
    Annals of hematology 76 (1998), S. 215-220 
    Details
    ISSN: 1432-0584
    Keywords: Key words FcγRIIIb deficiency ; NA1/NA2 polymorphism ; NA"null" ; SH antigen
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  A 27-year-old man with an allergy to house dust mites was found to lack the FcγRIIIb on his neutrophils. Cell surface marker and PCR techniques were used to investigate possible reasons for this deficiency. Agglutination and immunofluorescence assays using the man's neutrophils together with NA1- and NA2-specific antibodies were negative, and there was no reaction with the FcγRIII-specific mAb 3G8. Indirect immunofluorescence demonstrated the presence of the CD24 molecule, which, like the FcγRIIIb, is anchored to the cell membrane by glycosylphosphatidylinositol. Thus a lack of the FcγRIIIb cell membrane anchor was excluded. PCR analysis confirmed the absence of the NA1 and NA2 alleles. The individual was therefore typed as NA"null". The products of those genes located together with the FcγRIIIB gene within a complex on chromosome 1 (q23–24) were examined. FcγRII was demonstrated on monocytes and B cells with the use of FcγRII-specific monoclonal antibodies. About 5% of the individual's peripheral blood monocytes were positive with the 3G8 antibody, indicating the presence of FcγRIIIa. From these data we concluded that the FcγRIIIb deficiency on the neutrophil cell surface of this individual is due to a lack of the FcγRIIIB gene while excluding a lack of the FcγRIIA and the FcγRIIIA genes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002770050392
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  • 7
    Electronic Resource
    Electronic Resource
    Comparison of the pharmacokinetic profile of metaclazepam in old and young volunteers (1985)
    Springer
    European journal of clinical pharmacology 29 (1985), S. 247-249 
    Details
    ISSN: 1432-1041
    Keywords: metaclazepam ; benzodiazepines ; (KC-2547) ; N-desmethyl-methaclazepam KC-3755) ; pharmacokinetics ; old and young volunteers ; side-effects ; age effect
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary A single-centre, open, Phase I-study comparison of the pharmacokinetics of a single dose of metaclazepam 10 mg, a new 1,4-benzodiazepine has been done in 10 older and 20 younger volunteers. No important age-related effect was found on the kinetics of metaclazepam or its N-desmethyl derivative, the principal metabolite in man.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00547431
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  • 8
    Electronic Resource
    Electronic Resource
    Minimal biliary excretion and enterohepatic recirculation of metoclopramide in patients with extrahepatic cholestasis (1993)
    Springer
    European journal of clinical pharmacology 45 (1993), S. 415-418 
    Details
    ISSN: 1432-1041
    Keywords: Metoclopramide ; Biliary excretion ; enterohepatic recirculation ; Nasobiliary drainages ; pharmacokinetics ; biliary obstruction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The biliary excretion and apparent oral clearance of metoclopramide (MCL) were determined after oral administration of 1 mg MCL/kg body weight to 10 patients suffering from extrahepatic cholestasis with nasobiliary tube for drainage of the common bile duct. A bilioduodenal endoprosthesis was subsequently fitted in 6 of these patients, i.e. the enterohepatic circulation was restored, and the apparent oral clearance was re-determined. Biliary excretion, comprising free MCL and the products of conjugation, accounted for less than 1% of the administered dose. In accordance with this, the median areas under the plasma concentration-time-curves AUC(0–15 h) in patients with intact and interrupted enterohepatic recirculation were of similar size. The pharmacokinetic values in patients with cholestasis (median apparent oral clearance 0.5 l·kg−1·h−1; median t1/2 4.5 h) were similar to those previously reported in patients with healthy liver function. We conclude that it is not necessary to adjust single doses of MCL in patients recovering from obstructive jaundice.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00315511
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  • 9
    Electronic Resource
    Electronic Resource
    On the complex formation of acridine dyes with DNA. VII. Dependence of the binding on the dye structurePart I-VI see reference 1-6. (1969)
    New York : Wiley-Blackwell
    Biopolymers 8 (1969), S. 595-608 
    Details
    ISSN: 0006-3525
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The binding constants for the complex formation of more than twenty ring nitrogen-and amino-substituted acridine derivatives with calf thymas DNA were measured by a fluorescence method. DNA quenches the fluorescence of the aminoacridine dyes so long as both amino hydrogens are not substituted. These dyes show an enhancement of their fluorescence intensity in the presence of DNA. Typical representatives of both are proflavine and acridine orange derivatives, respectively. A discussion of steric and electronic influences of various substituents attached to the ring nitrogen and amino groups on the binding led to the concept of different conformations for intercalated acridines without amino groups and the aminoacridines. The electrostatic binding site of the former seems to be the positively charged ring nitrogen, while the binding sites in the aminoacridines are so located that the amino groups are directed towards the negatively charged DNA phosphates.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bip.1969.360080504
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