ISSN:
1573-6881
Keywords:
NM23
;
NDP kinases
;
c-myc
;
transcription factor
;
single-strand DNA-binding proteins
;
architectural transcription factor
;
metastasis
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Chemistry and Pharmacology
,
Physics
Notes:
Abstract In this paper, we studied the interaction of the human isoform B of nucleoside diphosphatekinase (NDP kinase B) with the nuclease hypersensitive element (NHE) present in the promoterelement of the c-myc oncogene. The DNA-binding properties of NDP kinase B and otherNDP kinases are compared and the nucleotide requirement for binding are discussed. Usingquantitative methods, we identified the DNA-binding sites on the protein and we proposed astructural model for a complex of one hexameric NDP kinase B with an oligonucleotide.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1023/A:1005593130867
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