Electronic Resource
Springer
Archives of toxicology
56 (1985), S. 212-213
ISSN:
1432-0738
Keywords:
Piroxicam
;
Indomethacin
;
Gastric ulcers
;
Ulcer Index
;
Therapeutic doses
;
Rat
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Comparative toxicity of indomethacin and piroxicam at low multiples of the human therapeutic dose was studied in inbred albino rats of both sexes. Using the drug-induced model, the two drugs were used to produce gastric ulcers in the rat. Both showed significant evidence of gastric ulceration measured by the ulcer index. The incidence of ulceration increased with dose for both drugs. Piroxicam produced a lower incidence of gastric ulcers than equivalent doses of indomethacin.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00333430
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