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  • 1
    Electronic Resource
    Electronic Resource
    Functional Comparison of Egr3 Transcription Factor Isoforms (2000)
    Oxford UK : Blackwell Science Ltd.
    Journal of neurochemistry 75 (2000), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: Recent studies indicate that the Egr family of transcription regulatory factors plays a key role in nervous system development and plasticity. In prior studies, we demonstrated that multiple isoforms of the Egr3 transcription regulatory factor are expressed in brain and appear to be generated by use of alternative translation start sites. To compare the functional activity of these isoforms, we have examined their ability to stimulate transcription of a luciferase reporter construct driven by the Egr response element. Analysis of a series of N-terminal truncation constructs indicates that Egr3 contains two distinct activation domains: one located in the segment upstream of Met106, the start site of the major truncated isoform Egr3β, and the other located C-terminal to all of the alternative translation start sites used to generate Egr3 isoforms detected in brain. We confirmed this inference by demonstrating that each of these segments is able to drive transcription when fused to the GAL4 DNA binding domain. Taken together, these studies indicate that the internal translation start sites present in Egr3 are used to generate Egr3 isoforms lacking the activation domain located N-terminal to Met106.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1471-4159.2000.0751352.x
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  • 2
    Electronic Resource
    Electronic Resource
    THE DISTRIBUTION OF MELANOCYTIC NAEVI IN MELANOMA PATIENTS AND CONTROL SUBJECTS (1989)
    Oxford, UK : Blackwell Publishing Ltd
    Australasian journal of dermatology 30 (1989), S. 0 
    Details
    ISSN: 1440-0960
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: A study of 121 melanoma patients and 139 control subjects was conducted among whites to examine and compare the distribution of non-dysplastic and dysplastic naevi and other pigmented lesions in each group. Melanoma patients had a mean of 97 melanocytic naevi which were greater than 2 mm in diameter and controls had a mean of 36 such naevi, while the medians were 58 and 22 respectively (p〈0.0001). 55% of melanoma patients and 17% of controls had at least one clinically determined dysplastic naevus, and 26% of melanoma patients and 6% of controls had at least 5 dysplastic naevi. Men were found to have more naevi on the trunk than women in both melanoma cases (p=0.01), and controls (p=0.005). Dysplastic naevi were most often found on the trunk and were present at this location in 51% of cases and 77% of controls. Melanoma patients and control subjects with dysplastic naevi, when compared to those without these lesions, had larger number of non-dysplastic naevi. Lentigines were more common among melanoma patients that among control subjects (p = 0.02). There were no differences in the number of non-dysplastic naevi among cases with light and dark hair and eyes, or among controls with these characteristics. There also was little variation in the number of naevi according to number of blistering sunburns.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1440-0960.1989.tb00399.x
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  • 3
    Electronic Resource
    Electronic Resource
    High-dose cisplatin and mitomycin C in advanced non-small cell lung cancer: a phase II study of the Northern California Oncology Group (1990)
    Springer
    Cancer chemotherapy and pharmacology 27 (1990), S. 243-247 
    Details
    ISSN: 1432-0843
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary To investigate chemotherapeutic dose intensity in advanced non-small-cell lung cancer (NSCLC), we evaluated a pharmacokinetically designed schedule of high-dose cisplatin (200 mg/m2 per 28-day cycle) plus mitomycin C. Between March 1987 and March 1989, 62 patients were registered for a phase II study of the Northern California Oncology Group (NCOG). The treatment schedule consisted of cisplatin in hypertonic saline given on a divided days 1 and 8 schedule (100 mg/m2 on each day) plus mitomycin C given at a dose of 8 mg/m2 on day 1 of each cycle. In 61 patients evaluable for response analysis, the overall response rate was 39% (24/61), with a complete response being achieved in 6% (4/61) of cases and a partial response, in 33% (20/61). The response according to reviewed histologic subtype included squamous, 53% of patients (10/19); large cell, 31% (4/13); and adenocarcinoma, 34% (10/29). The median survival for all patients was 19.3 weeks. The mean cisplatin and mitomycin C delivered dose intensities in this study were 45 mg/m2 per week (90% of the projected dose) and 1.5 mg/m2 per week (75%). The toxicity of this combination regimen in the 62 enrolled patients was significant but manageable. Leukopenia (WBC, 〈1,000/mm3) and thrombocytopenia (platelets, 〈25,000/mm3) occurred in 3# and 8% of patients treated, respectively. Dose-limiting renal toxicity and clinically significant ototoxicity developed in 8 patients each (13%), and a peripheral sensory neuropathy was observed in 17 cases (27%). Whether this type of dose-intensive therapy results in an improved therapeutic index in NSCLC is currently being evaluated in a randomized comparative trial versus standard-dose cisplatin therapy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00685721
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  • 4
    Electronic Resource
    Electronic Resource
    Effective cell loss analysis of a nonblocking ATM switch with nonuniform traffic (1996)
    Springer
    Journal of network and systems management 4 (1996), S. 7-29 
    Details
    ISSN: 1573-7705
    Keywords: Effective cell loss ; ATM switch ; nonuniform traffic ; matrix-geometric solution technique
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science
    Notes: Abstract This paper quantifies a trade-off existing between cell loss and cell delay in an ATM switch with arbitrary input and output buffer sizes. TheEffective Cell Loss is introduced as a cell loss performance measure which combines both the cell loss due to buffer overflow and the cell loss due to excessive delay. ThisEffective Cell Loss measure allows one to design optimal input and output buffer sizes for a given cell loss requirement. Our analysis is versatile enough to easily study the adverse effect due to nonuniform traffic patterns at a switch. Study shows that the nonuniform traffic may jeopardize ATM switches designed under the uniform traffic assumption. For some examples, we have provided both numerical and computer simulation results to show the validity and usefulness of our analysis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02139045
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  • 5
    Electronic Resource
    Electronic Resource
    The prognostic implications of histologic classification and bromodeoxyuridine labeling index of mixed gliomas (1994)
    Springer
    Journal of neuro-oncology 19 (1994), S. 113-122 
    Details
    ISSN: 1573-7373
    Keywords: mixed glioma ; bromodeoxyuridine ; cell kinetics ; immunohistochemistry ; astrocytoma ; oligodendroglioma ; ependymoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary To clarify the biological and clinical behavior and prognosis of mixed gliomas, 47 patients underwent intraoperative bromodeoxyuridine (BrdU) labeling studies. The mean age was 27.8 years at symptom onset and 31.8 years at labeling (median, 36 years). Forty-five tumors were supratentorial, 30 were frontal, and two were cerebellar; 16 were recurrent at labeling. The median labeling index (LI) was 1% (range,〈1 to 15.1%). Forty-six tumors had oligodendroglial and astrocytic elements, and one had astrocytic and ependymal elements. The median LI was 4.4% in recurrent tumors and 〈1% in primary tumors. A higher BrdU LI correlated with an increased risk of recurrence and a shorter time to recurrence. During a median follow-up of 16 months, four patients died; each had a BrdU LI≥4.4%. The median time to recurrence was 4.5 months for tumors with BrdU LI's 〉5% but was not reached for tumors with LI's 〈5% (p〈 0.003). The histologic grade of the oligodendroglial component correlated with the median time to recurrence (8 months for Smith Grade C tumors, not reached for Smith Grade B tumors; p〈0.05); there were too few cases to evaluate the median times to recurrence of Smith Grade A and Grade D tumors. The median time to recurrence was not reached for any astrocytic grade, and there were no significant differences in the Kaplan-Meier survival curves. These findings suggest that the BrdU LI and the grade of the oligodendroglial component of mixed gliomas have prognostic significance.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01306452
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