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  • 1
    Electronic Resource
    Electronic Resource
    Endorectal ultrasonography for the assessment of rectal wall invasion in intrapelvic tumor: A preliminary report (1999)
    Melbourne, Australia : Blackwell Science Pty
    International journal of urology 6 (1999), S. 0 
    Details
    ISSN: 1442-2042
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background: The purpose of the present study was to determine the usefulness of endorectal ultrasonography (ERUS) in assessing rectal wall involvement in intrapelvic tumors. Methods: Rectal wall invasion was assessed in 16 patients; 14 with deeply invasive bladder tumors, one with prostatic leiomyosarcoma, and one with prostatic leiomyoma. Computed tomography (CT), magnetic resonance (MR) imaging and ERUS with a flexible-type radial scanner (7.5 MHz) were used and the results were compared with the histopathologic findings in surgical specimens. Results: The normal rectum was shown by ERUS to be a five- or seven-layer structure. Characteristic abnormal ERUS findings included disappearance of the perirectal fat tissue layer with or without disruption of the propria muscle layer. Endorectal ultrasonography accurately assessed rectal wall involvement in all four patients who had two bladder tumors, plus the one patient with prostatic leiomyoma and the one with prostatic leiomyosarcoma. However, ERUS overstaged one of 12 bladder tumors with no rectal wall involvement, which was strongly adhesive to the rectum because of an inflammatory change but had no tumor invasion. There were no cases of understaging by ERUS. In comparison, CT accurately assessed rectal wall involvement in two patients, but overstaged in three and understaged in two. Magnetic resonance imaging, which was performed in 14 patients, accurately assessed rectal wall involvement in two patients, but overstaged in three and understaged in one. Conclusion: This preliminary study suggests that ERUS more accurately assesses rectal wall involvement in intrapelvic tumor than CT or MRI.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1442-2042.1999.00066.x
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  • 2
    Electronic Resource
    Electronic Resource
    Intraoperative Pleural Lavage in Esophageal Carcinoma (1999)
    Springer
    Annals of surgical oncology 6 (1999), S. 305-307 
    Details
    ISSN: 1534-4681
    Keywords: Esophageal carcinoma ; Squamous cell carcinoma ; Pleural lavage cytology ; Dissemination
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background: Cytological examination of intraoperative pleural or peritoneal lavage specimens is useful for predicting outcomes for patients with various carcinomas. There have been few reports regarding cytological examination of pleural lavage fluid in esophageal carcinoma. Methods: Intraoperative pleural lavage fluid was collected before and after esophagectomy and was examined by Papanicolaou and Giemsa staining for 78 patients with esophageal carcinoma. Results: Although epithelial cells were found for 29 patients, only blood cells were detected for 48. The remaining one patient exhibited no cells in the specimen. For 4 of 78 (5.2%) patients, tumor cells were detected in the pleural lavage fluid after esophagectomy. Three of these four patients had T4 tumors. Conclusions: Positive cytological findings for pleural lavage fluid, using Papanicolaou and Giemsa staining, is correlated with regrowth of residual tumor and poor prognosis in esophageal carcinoma.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s10434-999-0305-z
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  • 3
    Electronic Resource
    Electronic Resource
    Angiogenesis as an unfavorable factor related to lymph node metastasis in early gastric cancer (1998)
    Springer
    Annals of surgical oncology 5 (1998), S. 585-589 
    Details
    ISSN: 1534-4681
    Keywords: Angiogenesis ; Lymphatic vessel invasion ; Lymph node metastasis ; Early gastric cancer
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background: Recent studies suggest that angiogenesis enhances tumor growth and metastasis. Lymph node metastasis influences the prognosis and selection of treatment modalities in cancers. In this study, the authors investigated the correlation between angiogenesis and clinicopathologic features to determine whether angiogenesis correlated with lymph node metastasis in early-stage gastric cancer. Methods: A total of 97 specimens from patients with early gastric cancer were studied by immunohistochemical methods using anti-Factor VIII-related antigen antibody. Results: Tumor size was significantly correlated with microvessel count, which increased as tumor size increased. Microvessel counts from tumors with lymphatic vessel invasion, lymph node metastasis, and submucosal invasion were significantly higher than those without. Furthermore, microvessel count was an independent factor that influenced lymph node metastasis (P=.0016) by multivariate logistic regression analysis. Conclusion: In the early stage of gastric carcinoma, angiogenesis is an independent factor that impacts on lymph node metastasis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02303826
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  • 4
    Electronic Resource
    Electronic Resource
    Carcinomatous Lymphatic Invasion in Early Gastric Cancer Invading Into the Submucosa (1999)
    Springer
    Annals of surgical oncology 6 (1999), S. 286-289 
    Details
    ISSN: 1534-4681
    Keywords: Lymphatic invasion ; Early gastric cancer ; Lymph node metastasis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background: Lymphatic invasion is a risk factor for lymph node metastases in patients with gastric cancer. No studies have been reported, however, on the correlation between lymphatic invasion and lymph node metastasis in early gastric cancer invading into the submucosa. Methods: We performed a retrospective analysis of lymphatic invasion in 170 patients with early gastric cancer invading into the submucosa. Results: Lymphatic invasion was found in 76 patients. Lymphatic invasion correlated significantly with the presence of lymph node metastasis and vascular invasion (P 〈 .05) and with the degree of cancerous submucosal involvement (P 〈 .05). The presence of lymph node metastasis also correlated with the grade of submucosal invasion and lymphatic invasion. The 5-year survival of patients with lymphatic invasion was poorer than that of patients without lymphatic invasion (P 〈 .05). Node-negative patients had similar survival, regardless of the presence of lymphatic invasion. All patients with severe lymphatic invasion had sm3 invasion and lymph node metastases. Conclusion: Although lymphatic invasion is the first stage of lymph node metastasis, lymphatic invasion in itself does not have clinical importance except for severe invasion in early gastric cancer. It is possible to predict lymph node metastases from the combined evaluation of degree of lymphatic invasion and submucosal involvement of the tumor in patients with early gastric cancer invading into the submucosa.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s10434-999-0286-y
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  • 5
    Electronic Resource
    Electronic Resource
    Prediction of incontinence following low anterior resection for rectal carcinoma (1997)
    Springer
    Diseases of the colon & rectum 40 (1997), S. 575-579 
    Details
    ISSN: 1530-0358
    Keywords: Incontinence ; Low anterior resection ; Rectal cancer ; Manometry ; Internal anal sphincter ; Maximum resting pressure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract PURPOSE: This study was performed to predict incontinence following low anterior resection for rectal cancer. METHODS: Preoperatively, 21 patients were evaluated via patient history and a physical examination that included anal manometric studies. Six months postoperatively, repeat manometric studies and clinical evaluations were performed to assess the level of continence. Degree of continence was graded based on severity of the dysfunction and grade of the continence score. RESULTS: The formula used for predicted postoperative resting pressure is as follows: predicted postoperative resting pressure=0.42 × preoperative resting pressure+1.56 × length of remaining rectum+12.37 (R 2 =0.58;P 〈0.001). It was demonstrated that patients with low predicted postoperative resting pressures (〈30 mmHg) had incontinence, and those with high predicted postoperative resting pressures (〉35 mmHg) were continent. There were significant correlations between length of the remaining rectum and ratio of the decrease in maximum resting pressure (postoperative/preoperative maximum resting pressure;r =0.63;P 〈0.01). CONCLUSIONS: Continence following low anterior resection may be influenced by maximum resting pressure function of the internal anal sphincter; if it is injured during surgery, incontinence will occur. We may be able to foretell incontinence by using the predicted postoperative resting pressure formula, which is calculated by using preoperative resting pressure measurements and then determining the length of the remaining rectum.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02055382
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  • 6
    Electronic Resource
    Electronic Resource
    Comparison of p53 expression in proximal and distal gastric cancer: Histopathologic correlation and prognostic significance (1997)
    Springer
    Annals of surgical oncology 4 (1997), S. 470-474 
    Details
    ISSN: 1534-4681
    Keywords: p53 overexpression ; Gastric cancer ; Prognosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background: The overexpression of p53 has been found to be correlated with prognosis of some carcinomas, including gastric cancer, but no studies have reported on its relationship to the location of gastric cancer. In the present study, we compared the p53 expression of proximal and distal gastric cancer concerning histopathology and prognosis. Methods: A total of 170 tumors in the patients with proximal (80 cases) and distal (90 cases) gastric cancer were studied by immunohistochemical methods. Results: p53 immunopositivity was detected in 28.8% of all tumors. The p53-positive expression in proximal gastric cancer was higher than in distal gastric cancer (38.8% vs. 20.0%, p〈0.05). A 5-year survival analysis showed that there is no significant difference between tumors that are p53 positive and p53 negative. No correlation was found between p53 expression and histopathology of gastric cancer. Conclusion: p53 nuclear staining is not useful as a prognostic indicator or as a parameter in gastric cancer.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02303670
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  • 7
    Electronic Resource
    Electronic Resource
    Antrum preserving double tract method for reconstruction following proximal gastrectomy (1988)
    Springer
    Surgery today 18 (1988), S. 114-115 
    Details
    ISSN: 1436-2813
    Keywords: double tract method ; proximal gastrectomy ; pancreaticocibal synchronism
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The antrum preserving double tract method was originally designed in order to gain the smooth transfer of larger foods through the duodenal route. Surgical improvement was then made at a few points when carrying out the anastomosis between the residual stomach and the jejunum. In the clinical field, this method is characterized by a better transfer of large foods into the duodenum than the conventional double tract method. The clinical investigation revealed that gastrin release remained after the operation due to both the good passage and the presence of food in the residual stomach. The antrum preserving double tract method is a reasonable and simple method which can maintain physiological pancreaticocibal synchronism.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02470857
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  • 8
    Electronic Resource
    Electronic Resource
    Hepatocellular carcinoma coexistent with adenomatous hyperplasia: Report of a case (1993)
    Springer
    Surgery today 23 (1993), S. 528-531 
    Details
    ISSN: 1436-2813
    Keywords: adenomatous hyperplasia ; multicentric development ; hepatocellular carcinoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We would like to draw attention to hepatic tumor-like lesions which frequently complicate the differential diagnosis of hepatocellular carcinoma (HCC), while considering their pathology and diagnosis by radiographic imaging. In particular, adenomatous hyperplasia is recognized as a precancerous lesion of HCC, and the relationship between adenomatous hyperplasia and the multicentric development of HCC is recognized. We observed a patient who demonstrated hyperplastic changes in both the liver cells and a well-differentiated HCC lesion adjacent to the adenomatous hyperplasia, suggesting a multicentric development of the HCC. The histopathological features of adenomatous hyperplasia are also described.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00730629
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  • 9
    Electronic Resource
    Electronic Resource
    Occult Lymph Node Metastasis in Gastric Cancer with Submucosal Invasion (1994)
    Springer
    Surgery today 24 (1994), S. 870-875 
    Details
    ISSN: 1436-2813
    Keywords: early gastric cancer ; metastatic lymph node ; occult metastasis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract To evaluate more precisely the incidence of lymph node metastasis in patients with submucosally invaded (sm) gastric cancer, three additional sections were made from the remaining half of 1,794 lymph nodes taken from 57 patients, for a detailed reexamination. Lymph node metastasis was demonstrated in 19 nodes from 11 patients by the initial routine examination; however, the detailed reexamination showed cancer involvement in a further nine lymph nodes from eight patients. Of these eight patients, metastasis had not been detected in any lymph nodes by routine examination in six. Macroscopically, the lesion was of the depressed or mixed type in six of the eight patients. From the intranodal location and growth pattern of the cancer foci, lymph nodes with occult metastasis were divided into the marginal sinus type, the medullary sinus type, and the mixed type, with the marginal type being found most frequently. The overall incidence of lymph node metastasis in patients with sm gastric cancer was as high as 29.8% (17/57) in this series. Moreover, a follow-up study revealed that two patients with occult metastasis died of cancer recurrence postoperatively. Accordingly, systematic regional lymph node dissection should be carried out at the time of surgery for sm gastric cancer.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01651001
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  • 10
    Electronic Resource
    Electronic Resource
    High serum alpha-fetoprotein concentration associated with pseudoinfarction of a cirrhotic liver: Report of a case (1996)
    Springer
    Surgery today 26 (1996), S. 818-821 
    Details
    ISSN: 1436-2813
    Keywords: alpha-fetoprotein (AFP) ; pseudoinfarction ; hepatocellular carcinoma (HCC)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We report herein the case of a 65-year-old man with cirrhosis of the liver in whom a portal vein thrombus was found to be the cause of a marked elevation in serum alpha-fetoprotein (AFP). The patient presented with fever and abdominal pain, and a diagnostic work-up revealed a liver mass and an increased serum AFP concentration of 91000 ng/ml. The mass gradually regressed, and the AFP concentration simultaneously decreased to 163 ng/ml. However, because hepatocellular carcinoma (HCC) could not be ruled out, a partial hepatectomy was performed. Histological examination of the resected specimen revealed a thrombus of the portal vein surrounded by the fibrosis associated with liver cirrhosis, but no neoplastic lesion was found. Thus, portal thrombus associated with liver cirrhosis might induce an extremely high level of AFP production.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00311644
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