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  • 1
    Electronic Resource
    Electronic Resource
    Neuropsychological follow-up of 12 patients with neuro-Behçet disease (1999)
    Springer
    Journal of neurology 246 (1999), S. 113-119 
    Details
    ISSN: 1432-1459
    Keywords: Key words Neuro-Behçet disease ; Neuropsychological evaluation ; Dementia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We analyzed the data obtained from neuropsychological evaluations of 12 neuro-Behçet Disease (NBD) patients who had been followed up for 35.6 ± 23.7 months with successive neuropsychological testing by a comprehensive battery. Memory impairment, which seems to stem basically from a retrieval deficit, was the major finding in this series. The most severely affected memory process was delayed recall, being impaired in all of the patients in the verbal and/or visual modalities. This was followed closely by an impairment in the process of acquisition and storage. In addition to the memory impairment, a “clinical impression of personality change” toward either disinhibition or apathy was seen in 8 of the 12 patients. Attention deficit was of the third highest frequency and was present in 7 patients, followed by deficits of executive functions of frontal system which were present in 5. Other cognitive domains were rarely involved. Neuropsychological status deteriorated insidiously, regardless of the neurological attacks during the follow-up period in most of the patients. Furthermore, our observations also showed the presence of cognitive decline prior to detectable lesions on CT or MRI, emphasizing the need for neuropsychological testing in NBD patients. The late stages of the disease seem to be reflected in MRI as an enlargement of the third ventricle and atrophy of the upper brainstem, which could be compatible with memory loss. Our series, a rather selected group, suggests that NBD can be associated with a special pattern of cognitive deficit, especially memory loss and personality change. The designation of any specific neurobehavioral syndrome for NBD, however, awaits further study.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004150050317
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  • 2
    Electronic Resource
    Electronic Resource
    Anti-αB-crystallin immunoreactivity in inflammatory nervous system diseases (2000)
    Springer
    Journal of neurology 247 (2000), S. 935-939 
    Details
    ISSN: 1432-1459
    Keywords: Key wordsαB-Crystallin ; Neuro-Behçet ; Multiple sclerosis ; Guillain-Barré syndrome ; Antibodies
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract αB-Crystallin, a small heat shock protein, is an immuno-dominant antigen with increased tissue expression in demyelination. To investigate the humoral response against αB-crystallin, the sera and CSF samples of patients with multiple sclerosis (MS), Guillain-Barré syndrome (GBS), neuro-Behçet's disease (NBD) and other non-inflammatory neurological disease (NIND) were screened by enzyme-linked immunosorbent assay for anti-αB-crystallin IgG and IgM antibodies. Serum and CSF IgG antibody responses to αB-crystallin were significantly elevated only in NBD patients (serum IgG, NBD 1.29±0.49 vs NIND 0.95±0.39, p=0.01; CSF IgG, NBD 1.22±0.64 vs. NIND 0.81±0.35, P=0.01). Similarly, high serum IgM antibody titres were also detected in NBD (1.83±0.72 vs. 1.16±0.49, P=0.0005) and in MS (1.57±1.07, P=0.046), whereas elevated CSF IgM responses were observed to be high only in GBS (2.09±1.09 vs. 1.41±0.7, P=0.007). Humoral responses against αB-crystallin are increased in NBD and GBS, which may implicate this central nervous system antigen in the causation and pathogenesis of these inflammatory nervous system disorders.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004150070049
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
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