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  • 1
    Electronic Resource
    Electronic Resource
    Panendoscopy as a screening procedure for simultaneous primary tumors in head and neck cancer (1996)
    Springer
    European archives of oto-rhino-laryngology and head & neck 253 (1996), S. 319-324 
    Details
    ISSN: 1434-4726
    Keywords: Panendoscopy ; Synchronous neoplasms
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Head and neck cancer is often associated with second primary neoplasms. These cancers most commonly involve other regions of the head and neck, esophagus, and lung. The majority of cases are also squamous cell carcinomas. In view of this rather frequent occurrence of multiple primary cancers and how they adversely affect the patient's survival, it becomes imperative to analyze how the clinician can intervene effectively. One such approach is to detect multiple primaries as early as possible. As such, panendoscopy as a part of the tumor-staging procedure has been advocated by many investigators to search for simultaneous second primary malignant neoplasms in patients presenting with head and neck cancer. In a 24-month period, data were gathered from 127 consecutive patients referred to University Hospital, Ghent with previously untreated, squamous cell carcinomas of the head and neck. One hundred-eighteen patients underwent an endoscopic examination under general anesthesia, during which 4 simultaneous second primary tumors were found in 3 patients. This represents an incidence of 3.4% of simultaneous second primary neoplasms. The results for the different parts of the endoscopy are discussed and compared with literature findings. Guidelines are given for the initial evaluation of the head and neck cancer patient.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00178285
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  • 2
    Electronic Resource
    Electronic Resource
    Structure and composition of stereocilia cross-links in normal and hydropic cochleas of the guinea pig (1993)
    Springer
    European archives of oto-rhino-laryngology and head & neck 250 (1993), S. 73-77 
    Details
    ISSN: 1434-4726
    Keywords: Cochlea ; Hydrops ; Stereocilia ; Cross-links ; Cytochemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Structure and composition of stereocilia cross-links were investigated cytochemically in normal and hydropic cochleas of the guinea pig. The electron-dense markers colloidal thorium and cationized ferritin were used for visualization. Side links as well as tip links were visualized using both markers. Cationized ferritin allowed a better visualization of the delicate cross-link substructure than did colloidal thorium. Following digestion with neuraminidase, cross-link reactivity for colloidal thorium was virtually abolished. However, the basic structure of the cross-links could still be observed as a result of routine post-fixation and contrast staining. In both 3- and 6-month hydropic cochleas glycocalyx reactivity of the stereocilia appeared to be unaltered, provided that stereocilia were still present. However, loss of cross-links of the outer hair cells — resulting in disarrangement of the stereociliary bundles — was observed in hydropic cochleas. Our results suggest that cross-links are a separate morphological and cytochemical entity, which is different from the glycocalyx. Furthermore, loss of stereocilia cross-links, with concomitant disarrangement of the outer hair cell stereociliary bundle, appears to be one of the early pathological features of surgically induced endolymphatic hydrops, which might be responsible for permanent sensorineural hearing loss.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00179301
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Corneal autoimmunity in a patient with relapsing polychondritis (1992)
    Springer
    European archives of oto-rhino-laryngology and head & neck 249 (1992), S. 296-299 
    Details
    ISSN: 1434-4726
    Keywords: Relapsing polychondritis ; Corneal autoimmunity ; Circulating antibodies
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We report our experiences with a patient with relapsing polychondritis, in whom circulating antibodies against corneal epithelium were determined by immunofluorescence before and after medical treatment. The results provide further evidence for an autoimmune pathogenesis of the disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00714497
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    The effect of buttermilk consumption on biofilm formation on silicone rubber voice prostheses in an artificial throat (1998)
    Springer
    European archives of oto-rhino-laryngology and head & neck 255 (1998), S. 410-413 
    Details
    ISSN: 1434-4726
    Keywords: Key words Laryngectomy ; Voice prosthesis ; Silicone rubber ; Biofilm ; Artificial throat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Biofilm formation on indwelling silicone rubber voice prostheses in laryngectomized patients is still the main reason for dysfunction of the valve, leading to frequent replacements. Within patient support groups in The Netherlands, laryngectomees have suggested that the consumption of buttermilk prolongs the life-time of indwelling silicone rubber voice prostheses. The aim of the present study was to compare biofilm formation on Groningen button voice prostheses in a so-called artificial throat. Ten prostheses were placed in a simulated control group and ten other prostheses in a group with a simulated consumption of 700 ml buttermilk three times a day. Biofilms were allowed to grow on the prostheses by inoculating two artificial throats with the total cultivable microflora (bacteria and yeasts) isolated from an explanted Groningen button voice prosthesis. After 3 days, one artificial throat was perfused three times daily with phosphate buffer (control group) for 8 days, while the other artificial throat was perfused with buttermilk. Prostheses removed from the artificial throat in the control group were covered with a thick biofilm. Scanning electron microscopy showed microcolonies growing into the silicone rubber, similar to the ingrowth observed on explanted Groningen buttons. The simulated consumption of buttermilk in the other artificial throat almost fully prevented the formation of a biofilm on the prostheses during the experimental period. These in vitro experiments in the artificial throat demonstrate that the deterioration of voice prostheses can be lessened by the daily intake of buttermilk through its inhibitory effects on biofilm formation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004050050088
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Magnetic resonance imaging of the inner ear in patients with idiopathic sudden sensorineural hearing loss (1998)
    Springer
    European archives of oto-rhino-laryngology and head & neck 255 (1998), S. 433-436 
    Details
    ISSN: 1434-4726
    Keywords: Key words Idiopathic sudden sensorineural hearing loss ; Viral labyrinthitis ; Diagnosis ; Magnetic resonance ; imaging
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Although gadolinium-enhanced magnetic resonance imaging (Gd-MRI) has been used to indicate the presence of a subclinical labyrinthitis in patients with idiopathic sudden sensorineural hearing loss (ISSHL), its sensitivity in daily clinical practice is unknown. We describe Gd-MRI findings in 27 ISSHL patients taking part in a prospective multicenter clinical trial. MRI findings were related to the severity of the hearing loss, vestibular involvement and the time interval between the occurrence of ISSHL and imaging. Pathological enhancement of the cochlea indicating a labyrinthitis was found in one patient with ISSHL. In 26 cases, no pathological enhancement could be established. Study results indicate that the present sensitivity of Gd-MRI is low for detecting subclinical viral labyrinthitis in patients with ISSHL. To improve the sensitivity of MRI in ISSHL, we recommend that imaging is performed as early as possible, preferably before treatment is started.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004050050093
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    Paper (German National Licenses)
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