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  • 1
    Electronic Resource
    Electronic Resource
    Cell-surface expression of H-2Db requires N-linked glycans (1987)
    Springer
    Immunogenetics 26 (1987), S. 31-35 
    Details
    ISSN: 1432-1211
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The question of whether beta-2 microglobulin (B2m)-independent expression of the mouse major histocompatibility complex (MHC) antigen H-2Db results from the atypical glycosylation pattern associated with this MHC antigen (i. e., three glycans instead of two) has been addressed. Cell-surface expression of transfected H-2Db in the B2m deficient cell line RIE was completely abolished by the drug tunicamycin (Tm). Introduction of a functional B2m gene by transfection did not re-establish cell-surface expression of Db in the presence of Tm. Tm had no effect, however, on the expression of a truncated Db molecule lacking the α1 and α2 domains which is glycosylated at amino acid position 256, suggesting that the Db molecule, unlike other class I antigens, possesses an unstable conformation in the α1 and/or α2 domains which requires the attachment of glycans before it is transported to the cell surface. Once attached, however, glycans may confer a stable α1/α2 conformation apparently peculiar to Db which allows cell-surface expression in the absence of B2m.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00345451
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Characterization of mice deficient in interleukin-1β converting enzyme (1997)
    New York, N.Y. : Wiley-Blackwell
    Journal of Cellular Biochemistry 64 (1997), S. 27-32 
    Details
    ISSN: 0730-2312
    Keywords: interleukin-1β converting enzyme ; gene targeting ; apoptosis ; IL-1β ; IL-1α ; inflammation ; Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Interleukin-1β converting enzyme (ICE) processes the inactive proIL-1β to the proinflammatory mature IL-1β. ICE belongs to a family of cysteine proteases that have been implicated in apoptosis. To address the biological functions of ICE, we generated ICE-deficient mice through gene targeting technology. ICE-deficient mice developed normally, appeared healthy, and were fertile. Peritoneal macrophages from ICE-deficient mice underwent apoptosis normally upon ATP treatment. Thymocytes from young ICE-deficient mice also underwent apoptosis when triggered by dexamethasone, gamma irradiation, or aging. ICE-deficient mice had a major defect in the production of mature IL-1β and had impaired IL-1α production on LPS stimulation in vitro and in vivo. ICE-deficient mice were resistant to LPS-induced endotoxic shock. J. Cell. Biochem. 64:27-32. © 1997 Wiley-Liss, Inc.
    Type of Medium: Electronic Resource
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    Paper (German National Licenses)
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