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  • 1
    Electronic Resource
    Electronic Resource
    Regional distribution of monoamines in the nucleus accumbens of the rat (1988)
    Springer
    Neurochemical research 13 (1988), S. 937-942 
    Details
    ISSN: 1573-6903
    Keywords: Dopamine ; noradrenaline ; serotonin ; nucleus accumbens ; regional distribution
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Monoamine concentrations were low in the rostral area of the nucleus accumbens. Their distributions were not identical. Differences were observed in the medial area. DA concentrations were high in both medial and caudal areas. Noradrenaline (NA) and serotonin (5-HT) concentrations were considerably lower than the dopamine (DA) concentration. The NA concentration was highest in the caudal area of the nucleus accumbens and the (5-HT) concentration was highest in the ventrocaudal area. There was a rostrocaudal decrease in the 3,4-dihydroxyphenylacetic acid (DOPAC)/DA and 5-hydroxyindole-3-acetic acid (5-HIAA)/5-HT ratios. Uptake of [3H]DA and [14C]choline was lowest in the rostral area. The K+-stimulated release of [14C]acetylcholine (ACh) was also lowest rostrally, but there was no rostrocaudal difference in the K+-stimulated release of [3H]DA. These results provide further evidence of the heterogeneity of the nucleus accumbens.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00970765
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  • 2
    Electronic Resource
    Electronic Resource
    Regional distribution of monoamines and dopamine D1-and D2-receptors in the striatum of the rat (1992)
    Springer
    Neurochemical research 17 (1992), S. 387-395 
    Details
    ISSN: 1573-6903
    Keywords: Dopamine ; D1-receptor ; D2-receptor ; monoamines ; striatum ; regional distribution
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Dopamine (DA) D1-and D2-receptor densities were determined in 18 discrete areas of the caudate-putamen-globus pallidus of male Wistar rats and compared to local DA concentrations. All three parameters were found to decrease caudally. The globus pallidus was distinguished by the low concentration of DA and its receptors and high noradrenaline, (NA) content. While there were no mediolateral differences in DA or DA D1-receptors, a clear mediolateral gradient was observed for DA D2-receptors which extended over several sections of the brain. The ratio of DA D1-to D2-receptors was significantly higher in the dorsal than in the ventral areas of the mediolateral and caudal striatum. This is the first report of clear dorsoventral differences in parameters relating to DA activity in the striatum. These findings may be of particular significance in understanding the functional dichotomy between the dorsal and ventral striatum.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00974582
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Effect of selective noradrenergic denervation on noradrenaline content and [3H]dopamine release in rat nucleus accumbens slices (1989)
    Springer
    Neurochemical research 14 (1989), S. 169-172 
    Details
    ISSN: 1573-6903
    Keywords: DSP4 ; nucleus accumbens ; noradrenaline ; dopamine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract DSP4 (N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine) treatment (50 mg/kg i.p., 10 days previously) significantly decreased the noradrenaline (NA) content of the rostral part of the nucleus accumbens. The medial and caudal areas were not affected. The nucleus accumbens appears to receive noradrenergic innervation predominantly from subcoeruleus nuclei of the pons-medulla while the locus coeruleus neurons project to the rostral area. The isoproterenol-induced enhancement of the K+-evoked release of [3H]dopamine (DA) was not affected by DSP4 treatment. Noradrenergic denervation does not appear to have been sufficient to cause up-regulation of postsynaptic β-adrenoceptors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00969634
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  • 4
    Electronic Resource
    Electronic Resource
    Lack of effect of chronic desipramine treatment on dopaminergic activity in the nucleus accumbens of the rat (1989)
    Springer
    Neurochemical research 14 (1989), S. 661-665 
    Details
    ISSN: 1573-6903
    Keywords: DA/ACh release ; DA D1/D2-receptors ; nucleus accumbens ; desipramine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The binding of [3H]SCH 23390 to dopamine (DA) D1-receptors was measured in the nucleus accumbens of rats treated chronically with desipramine for 14 days. DA D1 — and D2-receptor binding using [3H]SCH 23390 and [3H]spiperone, respectively as ligands, was determined in rats treated for 28 days. NeitherB max norK d values were influenced by chronic desipramine treatment. In addition, chronic desipramine treatment (28 days) did not influence the dose dependent, quinpirole (10–1000 nM)-mediated inhibition of the electrically stimulated release of [3H]DA and [14C]ACh from nucleus accumbens slices or the dose dependent increase in [3H]DA release and decrease in [14C]ACh release in the presence of 1 and 10 μM nomifensine. Therefore, our results suggest that the effect of chronic antidepressant treatment cannot be attributed to changes in either DA D11-or D2-receptor binding or DA D2-receptor function in the nucleus accumbens.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00964876
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  • 5
    Electronic Resource
    Electronic Resource
    Increased dopamine D2 receptor-mediated inhibition of [14C]acetylcholine release in the dorsomedial part of the nucleus accumbens (1989)
    Springer
    Neurochemical research 14 (1989), S. 877-881 
    Details
    ISSN: 1573-6903
    Keywords: Dopamine ; D2 receptors ; nucleus accumbens ; acetylcholine ; quinpirole ; sulpiride
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Dopamine (DA) D2 receptor-mediated inhibition of the K+-stimulated release of [14C]acetylcholine (ACh) from prelabeled rat dorsomedial nucleus accumbens slices was found to be 1.7 times greater than that observed in dorsorostral and ventromedial slices. This observation is consistent with the 1.9 fold higher DA D2 receptor density found in the dorsomedial area. In contrast, there were no differences in the DA D2 receptor-mediated effects on [3H]DA release in these areas. In addition, DA D2 receptor-mediated effects on [3H]DA and [14C]ACh release could not be demonstrated in the ventrorostral part of the nucleus accumbens consistent with the fact that DA D2 receptors were barely detectable in this area. The results suggest that cholinergic terminals in the dorsomedial part of the nucleus accumbens are under greater inhibitory DA control than in other areas of the nucleus accumbens.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00964818
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Effect of amygdaloid kindling on rat striatal dopamine D1- and D2-receptors (1994)
    Springer
    Neurochemical research 19 (1994), S. 827-831 
    Details
    ISSN: 1573-6903
    Keywords: Amygdala ; kindling ; striatum ; dopamine D1- and D2-receptors
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effect of kindling on dopaminergic (DA) neurotransmission was assessed by measuring dopamine D1- and D2-receptor binding in the dorsal and ventral striatum of rats either 2 hours (short-term) or 3–4 weeks (long-term) after the last kindled seizure. Kindling did not have any significant long-term effect on DA D2-receptor Kd or Bmax values in the dorsal or ventral striatum or on DA D1-receptor parameters in the dorsal striatum. The short-term effect of kindled seizures was to abolish the asymmetry in DA D2-receptor density observed in the dorsal striatum of control rats. DA D1-receptor density was also increased in the dorsal striatum contralateral to the kindled amygdala of short-term rats. The short-term effects support the notion that limbic seizures can modify the lateral imbalance of DA activity in the striatum.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00967451
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