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  • 1
    Electronic Resource
    Electronic Resource
    Role of PACAP in the Female Reproductive Organs (1996)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 805 (1996), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1996.tb17500.x
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  • 2
    Electronic Resource
    Electronic Resource
    PACAP Occurs in Sensory Nerve Fibers and Participates in Ocular Inflammation in the Rabbit (1996)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 805 (1996), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1996.tb17556.x
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  • 3
    Electronic Resource
    Electronic Resource
    Immunoglobulin-A producing probably primary lymphoma of the breast (1983)
    Springer
    Virchows Archiv 399 (1983), S. 355-360 
    Details
    ISSN: 1432-2307
    Keywords: Primary breast malignant lymphoma ; Histopathology ; Immunohistochemistry ; IgA production
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A breast tumour from a 65-year old woman was found to be a primary non-Hodgkin lymphoma, a very rare primary malignancy in this location. The lymphoma was of a diffuse histiocytic type according to the classification of Rappaport, or polymorphic immunocytoma according to the Kiel classification. Immunohistochemistry, not previously reported for breast lymphomas, revealed the production of IgA. In the serum this appeared as an IgA M-component which was greatly reduced after tumour removal. Immunological properties of primary breast lymphomas are reviewed, we suggest further extended studies with the immunohistochemical use of marker substances for the evaluation of prognosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00612953
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  • 4
    Electronic Resource
    Electronic Resource
    Surface histamine receptors in rat peritoneal mast cells. Separation of receptor-bearing cells via binding to a histamineprotein conjugate, Cell-ectTM (1984)
    Springer
    Inflammation research 14 (1984), S. 370-372 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The Seragen Cell-ect Total Histamine kitTM was used to separate histamine receptor-bearing rat peritoneal mast cells from cells lacking these receptors. It was found that approximately 75% of the peritoneal mast cell population carried cell surface histamine receptors. The results further suggest that the mast cell histamine receptors present are mainly of an H1-type, as judged by the capacity of a specific H1-antagonist to reduce the histamine receptor-dependent cell adhesion. Moreover, an H1-agonist is less efficient in this respect and an H2-antagonist does not affect the cell adhesion at all. A possible functional role for these receptors, however, remains to be clarified.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01973830
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  • 5
    Electronic Resource
    Electronic Resource
    Sodium fluoride evoked histamine release from mast cells. A study of cyclic AMP levels and effects of catecholamines (1983)
    Springer
    Inflammation research 13 (1983), S. 132-137 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Calcium triggers the secretion of histamine from mast cells after previous exposure to sodium fluoride. The secretory process can be divided into a fluoride-activation step and a calcium-induced secretory step. It was observed that the fluoride-activation step is accompanied by an elevation of cAMP levels within the cells. The attained high levels of cAMP persist during histamine release. It was further found that catecholamines do not markedly alter the fluoride-induced histamine release. It was also confirmed that the second, but not the first, step in sodium fluoride-induced histamine secretion is inhibited by theophylline.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01967316
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  • 6
    Electronic Resource
    Electronic Resource
    What — if any — is the role of adrenergic mechanisms in histamine release from mast cells? (1981)
    Springer
    Inflammation research 11 (1981), S. 60-66 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effects of catecholamines on histamine release from rat peritoneal mast cells, was studied in an in vitro system. It was found that norepinephrine (10−5–10−3 M) exerts a significant, dose related, repressive effect on compound 48/80-induced histamine release. This effect is greatly potentiated by β-antagonists and is noticeable throughout the concentration range 10−11–10−3 M norepinephrine. Phentolamine diminishes the repressive effect that norepinephrine shows at 10−5 M. Norepinephrine (10−5 M) totally inhibits the progressive histamine release induced by both compound 48/80 and strontium (10 μM) in non-Ca2+-depleted cells. The release that is dependent on extracellular calcium is inhibited by norepinephrine. The repressive effect of norepinephrine at 10−3 is counteracted by 5.6 mM d-glucose, 2-deoxyglucose abolishes this effect. The repression of histamine release by 10−5 M norepinephrine is not influenced byd-glucose. These results suggest that the effects on histamine release, observed within a low concentration range of norepinephrine (〈10−3 M), may be due to α-adrenoreceptor mechanisms and an interference in transmembrane calcium transport. Our data further suggest that norepinephrine at 10−3 M may inhibit oxidative phosphorylation. Isoproterenol and epinephrine (10−9–10−5 M) show little effect on 48/80-induced histamine release in a normal medium. However, when calcium is excluded from the medium, histamine release is potentiated. These results seem to indicate that isoproterenol and epinephrine act by displacing intracellular calcium, making it available for the exocytosis process.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01991457
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  • 7
    Electronic Resource
    Electronic Resource
    Adrenergic and cholinergic nerves of bovine, guinea pig and hamster salivary glands (1973)
    Springer
    Cell & tissue research 138 (1973), S. 407-420 
    Details
    ISSN: 1432-0878
    Keywords: Salivary glands ; Autonomic innervation ; Acetylcholine-esterase ; Fluorescence microscopy ; Electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The distribution of formaldehyde-induced fluorescence and acetylcholine-esterase (AChE) activity was histochemically investigated in certain salivary glands of the cow (submandibular gland), guinea pig and hamster (submandibular and sublingual glands). Adrenergic nerves occur around the secretory acini of the bovine, guinea pig and hamster submandibular glands, as well as around those of the hamster sublingual gland. The mucous secretory acini of the guinea pig sublingual gland, however, seem to be devoid of adrenergic nerve supply. Except in the sublingual gland of the hamster, no adrenergic nerves occur in relation to duct cells. The pattern of AChE activity is similar to that of adrenergic nerves. Thus, AChE-positive nerves form a network around secretory acini of all the five glands examined. Furthermore, AChE activity was also observed in nerve fibres in close proximity to striated duct cells. Both adrenergic and AChE-containing fibres were observed around blood vessels of different sizes. Ganglionic cells are occasionally to be seen; they all display AChE-activity. No adrenergic ganglionic cells were observed in any of the glands examined. All glands were also studied in the electron microscope. Interest was focussed on the fine structure of the autonomic nerves with special reference to their contents and type of storage vesicles. The content of noradrenaline was chemically determined in each type of salivary gland studied.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00307102
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  • 8
    Electronic Resource
    Electronic Resource
    Co-existence and origin of peptidergic and adrenergic nerves in the guinea pig uterus (1988)
    Springer
    Cell & tissue research 254 (1988), S. 517-530 
    Details
    ISSN: 1432-0878
    Keywords: Uterus ; Autonomic innervation ; Neuropeptides ; Immunocytochemistry ; Retrograde tracing ; Pregnancy ; Guinea pig
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The occurrence and distribution of peptidergic nerves in the guinea pig uterus was studied by means of immunocytochemistry using numerous neuropeptide antisera. Neuropeptide Y (NPY)-immunoreactive (IR) nerves were the most abundant, whereas substance P (SP)-, calcitonine gene-related peptide (CGRP)-, and neurokinin A (NKA)-IR nerves were less frequent, and peptide histidine isoleucine (PHI)-IR nerves were the most sparse. Chemical sympathectomy by means of 6-hydroxydopamine, and capsaicin treatment revealed the division of the peptidergic nerves into three separate populations: (1) NPY-IR nerves, which co-existed with adrenergic nerves, (2) SP-, CGRP-and NKA-IR nerves, which mutually co-existed, and (3) PHI-IR nerves. Parallel-running adrenergic/NPY-IR and SP-IR nerves could be found with very similar although not completely identical morphological appearance. Paracervical ganglia contained neurotensin-and dynorphin A-IR cell bodies in addition to cell bodies with immunoreactivities similar to those in prevertebral ganglia. Combined retrograde tracing with True blue and immunocytochemistry showed that the adrenergic and NPY-IR uterine nerves originate in paracervical and prevertebral ganglia. In the prevertebral ganglia the cellular origin was the same for adrenergic and NPY-IR nerves. In contrast, SP-, CGRP-,and NKA-IR nerves originated in dorsal root ganglia. At full-term pregnancy all the neuropeptide immunoreactivities had vanished, probably reflecting a fetus-induced general nerve degeneration.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00226501
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  • 9
    Electronic Resource
    Electronic Resource
    S-100-immunoreactive nerves in the guinea-pig uterus with reference to ultrastructural correlations: Effects of chemical sympathectomy and pregnancy (1987)
    Springer
    Cell & tissue research 250 (1987), S. 241-249 
    Details
    ISSN: 1432-0878
    Keywords: Uterus ; Autonomic innervation ; S-100 immunoreactivity ; Nerve ultrastructure ; Neuronal plasticity ; Guinea-pig
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary In the guinea-pig uterus, by use of an indirect immunofluorescence method, S-100 immunoreactivity was found to be restricted to nerves that corresponded in number, distribution and type to adrenergic axons and preterminals. With advancing pregnancy S-100 immunoreactivity completely disappeared in uterine tissue adjacent to a fetus, in parallel with an ultrastructural degeneration of the adrenergic innervation. In the cervix and the uterine horn devoid of a fetus, however, the number and distribution of S-100-immunoreactive nerves was seemingly unchanged and no ultrastructural changes were found in adrenergic nerves. In contrast, chemical sympathectomy produced by 6-hydroxydopamine did not change S-100 immunoreactivity of uterine nerves. These findings suggest that there are differences in the denervation effected by chemical and by pregnancy-induced sympathectomy. The latter probably represents a special type of adrenergic denervation by inducing a degeneration of Schwann cells in addition to destruction of neuronal structures. This may explain the differences in the speed of regeneration of uterine adrenergic nerves following the two types of denervation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00219068
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  • 10
    Electronic Resource
    Electronic Resource
    Nitric oxide synthase-containing, peptide-containing, and acetylcholinesterase-positive nerves in the cat lower oesophagus (1994)
    Springer
    Journal of molecular histology 26 (1994), S. 721-733 
    Details
    ISSN: 1573-6865
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The innervation of the cat lower oesophagus, including the lower oesophageal sphincter, was studied by enzyme histochemistry, immunohistochemistry, and confocal microscopy. In the lower oesophageal sphincter, and at a level 2 cm above it, no apparent differences were seen in the nerve distribution pattern. Among the nerve populations studied, acetylcholinesterase (AChE)-positive nerves were the most abundant in both these regions. The density of AChE-positive nerves was particularly marked in the circular muscle layer. A rich supply of nitric oxide synthase (NOS)-containing nerves was identified by using an antiserum against neuronal NOS, or by enzyme histochemical staining for NADPH diaphorase activity. Vasoactive intestinal peptide (VIP)-immunoreactive nerves had a similar distribution pattern as NOS-immunoreactive nerves, and nerves displaying immunoreactivity for NOS and VIP often showed profiles coinciding with AChE-positive nerves. As judged by confocal microscopy, immunoreactivities for helospectin, pituitary adenylate cyclase-activating peptide (PACAP) and VIP, to a large extent were found in the same nerves. At a level 7 cm above the lower oesophageal sphincter, the total nerve supply was less than in the sphincter itself and 2 cm above it. Immunoreactivity towards VIP, PACAP and helospectin was also found to co-exist with NOS and neuropeptide Y within the same nerve structures. It is concluded that there is an intricate innervation pattern in the feline lower oesophagus reflecting the complexity in the regulation of its motility.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00158204
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