ISSN:
1434-193X
Keywords:
Amino alcohols
;
Polymers
;
Enantioselective reagents
;
Catalysis
;
Merrifield resins
;
Chemistry
;
General Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
Starting from simple amino acid esters and Merrifield resins, a small library of polymer-bound chiral-β-amino alcohols can be prepared. By reaction with LiALH4 the corresponding chiral reducing agents are obtained, having structural variations at both the α and β positions. All supported reagents are able to reduce acetophenone to 1-phenylethanol. Enantioselectivity is observed when the steric hindrance in the chiral fragment is increased. Best results are obtained for the supported derivative of α,α-diphenyl phenylalaninol.
Additional Material:
2 Tab.
Type of Medium:
Electronic Resource
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