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  • 1
    Electronic Resource
    Electronic Resource
    Immunogenicity of foot-and-mouth disease virus grown in BHK-21 suspensioncells. Correlation with cell ploidy alterations and abnormal expression of the α5β1 integrin
    Amsterdam : Elsevier
    Vaccine 12 (1994), S. 159-166 
    Details
    ISSN: 0264-410X
    Keywords: BHK-21 cells ; Foot-and-mouth disease vaccines ; cell ploidy ; integrins ; virus receptors
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0264-410X(94)90055-8
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Isolation of mononuclear cytotoxic cells from cattle vaccinated against foot-and-mouth disease (1992)
    Springer
    Archives of virology 122 (1992), S. 293-306 
    Details
    ISSN: 1432-8798
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Mononuclear cells from peripheral blood leucocytes of foot-and-mouth disease (FMD) vaccinated cattle underwent blast transformation after in vitro culture with purified, inactivated, 146 S FMD virus antigen. From the prolonged culture of blast cells in medium with Interleukin-2 (5–10 U/ml), CD 45-positive effector cells were derived, which showed a potent, non MHC-restricted activity against virus-infected cells, the extent of which was inversely correlated with multiplicity of infection (MOI). Extensive characterization of effector cells by means of monoclonal antibodies (MAbs) in flow cytometry, lysis of various cell populations with MAbs and complement, Fc receptor analysis and51Cr release assays indicated that the isolated cells share some phenotypic and functional features of the human and murine Large Granular Lymphocyte/Natural Killer (N.K.) lineage.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01317191
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Chaperonin 10 of Mycobacterium tuberculosis induces a protective immune response to foot-and-mouth disease virus (1999)
    Springer
    Archives of virology 144 (1999), S. 905-919 
    Details
    ISSN: 1432-8798
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary.  Chaperonin 10 of M. tuberculosis conferred partial or total protection against generalized foot-and-mouth disease (FMD) in guinea-pigs challenged with O1 Lausanne FMD virus. Chaperonin 10-immunized animals mounted an antibody response to the protein, one epitope of which was found in the C-terminal half. A similar recognition pattern was observed in FMD-convalescent guinea-pigs, swine and cattle. Anti-chaperonin 10 sera showed antiviral activity against FMDV-infected BHK-21 cells. There was strong evidence that early after infection these cells actively secrete their histones and that antisera to the chaperonin recognize them. The same antisera reacted with purified histones in immunoblotting. Most important, exogenously added histones abrogated the anti-viral activity of the antiserum and an anti-histone monoclonal antibody had strong antiviral activity against FMDV-infected BHK-21 cells. These results are consistent with previous reports on displacement of histones from the nuclear compartment and immune recognition of self-histones after viral infections. On the whole, they * indicate that M. tuberculosis chaperonin 10 enables the immune system to react against early abnormalities of virus-infected cells; this is accomplished by antibody cross-reacting with histones released during virus infection.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s007050050555
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  • 4
    Electronic Resource
    Electronic Resource
    Genotypic and phenotypic changes of BHK-21 cells grown in suspension cultures (1993)
    Springer
    Cytotechnology 11 (1993), S. S106 
    Details
    ISSN: 1573-0778
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Abstract The propagation of foot-and-mouth disease virus on BHK-21 suspension cells, although economically convenient, may yield a scarcely immunizing antigen. Helpful insights were obtained by investigating a few genotypic and phenotypic features of the cell cultures. The appearance of polyploid populations, higher cell concentrations at the end of culturing, the progressive reduction of spreading on surfaces and an abnormal expression of the α5β1 integrin were found to be correlated with the number of passages in suspension culture. The observed modifications in the normal course of the cell-cycle and in the expression of some surface proteins point at a possible mechanism of virus damages arising from defective cellular functions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00746070
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  • 5
    Electronic Resource
    Electronic Resource
    Post-fire resprouting of shrubby species in Mediterranean maquis (1991)
    Springer
    Plant ecology 96 (1991), S. 137-143 
    Details
    ISSN: 1573-5052
    Keywords: Fire ; Mediterranean maquis ; Vegetative resprouting
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The vegetative resprouting of mediterranean maquis shrubby species was examined eight years after fire. Post-fire regeneration occurs through the resprouting of stumps. All species (Quercus ilex L., Phillyrea latifolia L., Arbutus unedo L., Erica arborea L., Pistacia lentiscus L.) show a rapid growth in the first years after fire, and a decrease already from 4th–5th year. All the species survived the fire and reconstituted a community similar to that unburned in a relatively short time span.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00044975
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    Paper (German National Licenses)
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