ISSN:
1432-1041
Keywords:
metronidazole
;
trichomonas vaginitis
;
children
;
pharmacokinetics
;
serum and saliva concentrations
;
therapeutic dosage schedule
;
anaerobic infection
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
,
Medicine
Notes:
Summary The pharmacokinetics of metronidazole was studied in 20 paediatric patients aged 6 weeks and 4 to 14 years, who had trichomonal vaginitis or an anaerobic bacterial infection. The dosage of metronidazole was about 10 or 20 mg/kg b.i.d. orally. The serum concentrations found in children and the corresponding calculated kinetic parameters were similar to those in adults after intake of an equal, weight-related dose. Metronidazole shows rapid diffusion into the saliva with a concentration ratio of about 1.0. This can provide the basis for an efficient non-invasive method of drug monitoring.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00613937
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