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  • 1
    Electronic Resource
    Electronic Resource
    Synthesis of Chiral Hydroxylated Quinolizidines via Vinylogous Bischler-Napieralski Nitrilium Ion Cyclizations (1994)
    s.l. : American Chemical Society
    The @journal of organic chemistry 59 (1994), S. 2092-2100 
    Details
    ISSN: 1520-6904
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/jo00087a026
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  • 2
    Electronic Resource
    Electronic Resource
    Respiratory and Vascular Responses to Simple Visual Stimuli in Autistics, Retardates and Normals (1980)
    Oxford, UK : Blackwell Publishing Ltd
    Psychophysiology 17 (1980), S. 0 
    Details
    ISSN: 1469-8986
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine , Psychology
    Notes: Experiment 1 examined changes in respiratory period, peripheral pulse amplitude and cephalic pulse amplitude in autistic, retarded and normal children as a function of stimulus novelty. The respiratory measure showed habituation in the retardates and normals but not in the autistic group. Measures of peripheral and cephalic pulse amplitude showed no habituation in any group, but a higher mean response level for autistics. Autistic children thus differed from both retarded and normal children in two respects: a failure to habituate phasic respiratory responses, and enhanced response magnitude in the vascular systems. This experiment was replicated using groups of preschool children and university students. Results indicated significant age effects in the vascular systems, with preschoolers showing enhanced response magnitude. It was thus argued that autistics may display a general developmental lag in phasic vascular response measures, and an additional specific deficit indicated by failure to habituate respiratory responses. The implications of these group differences were discussed in relation to the etiology of autistic psychopathology.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1469-8986.1980.tb02294.x
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  • 3
    Electronic Resource
    Electronic Resource
    Left Ventricular Aneurysmectomy: Endoventricular Circular Patch Plasty or Septoexclusion (2003)
    350 Main Street , Malden , MA 02148 , USA. , and 9600 Garsington Road , Oxford OX4 2DQ , UK . : Blackwell Science Inc
    Journal of cardiac surgery 18 (2003), S. 0 
    Details
    ISSN: 1540-8191
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract Background: Septoexclusion is a technique described by Guilmet in the mid 1980s. Its indications and midterm results are evaluated and compared to those obtained with the Dor operation. Methods: From January 1998 to April 2001, 79 patients had an exclusion of scars following myocardial infarction in left anterior descending artery (LAD) territory. Fifty of them (63.3%) had the Dor operation (Group D) and 29 (36.7%) the Guilmet operation (Group G). Dor technique was used when the involvement of the septum and the free wall was roughly similar. Guilmet technique was indicated when the septum was involved at a greater extent than the free wall. Ejection fraction (EF) was lower and end-diastolic volumes were higher in Group G. Incidence of functional mitral regurgitation was similar in both groups. Results: Thirty-day mortality was 7.6% (8.0% in Group D versus 6.9% in Group G,p = ns). After a mean of21.0 ± 8.5months, five patients (6.9%) died, two in Group D and three in Group G. Causes of death were cardiac related in four and not cardiac related in one. Mean follow-up of the 68 survivors was24.3 ± 12.0months (range: 4-38 months). Fifty patients (73.5% of the survivors) improved (28 in Group D and 22 in Group G,p = 0.026), whereas in 18, New York Heart Association (NYHA) class remained unchanged or worsened. Both groups showed an increase of EF and a volumetric reduction, whereas stroke volume remained unchanged. Fewer patients had mitral regurgitation than in the preoperative period (41.3% versus 65.8%, p = 0.013) and at a lesser extent (1.7 ± 0.7versus0.7 ± 0.6, p 〈 0.001). Conclusions: Our results show that both Dor and Guilmet techniques are effective in the surgical treatment of left ventricular dyskinetic or akinetic areas related to LAD territory. Each technique has its own indications and has to be addressed to patients with different extension of septal scars.(J Card Surg 2003;18:93-100)
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1540-8191.2003.02016.x
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  • 4
    Electronic Resource
    Electronic Resource
    Left Anterior Small Thoracotomy (LAST): Mid-term Results in Single Vessel Disease (1998)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of cardiac surgery 13 (1998), S. 0 
    Details
    ISSN: 1540-8191
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract Background:Left anterior descending artery grafting using the left internal mammary artery via a left anterior small thoracotomy (LAST) gained new popularity in 1994. We review our experience in 250 of 512 patients who underwent a LAST in single vessel left anterior descending artery disease from November 1994 to October 1997. Methods: Left anterior descending artery stabilization was obtained pharmacologically and mechanically. Two patients (0.8%) had percutaneous transluminal coronary angioplasty at a mean of 23 ± 5 days; 172 (68.8%) patients had early postoperative angiography. Results: Eight conduits were occluded (patency rate 95.30%). There was only one late death. Cumulative angiography and Doppler flow evaluation showed that 96.8% of the anastomoses were patent and 95.6% were both patent and nonrestrictive. At a mean follow-up of 16.3 ± 9.3 months, 9 (3.6%) patients had redo-surgery due to anastomotic/conduit failure and 249 (99.6%) patients were alive and asymptomatic. No patients had acute myocardial infarction. The 35-month actuarial survival rate was 99.6%± 0.4%, and the event-free survival rate for the entire experience was 93.7%± 1.3%. If only the last 157 patients are considered, at 18 months event-free survival was higher than in the entire group of patients (96.4%± 1.4% vs 93.7%± 1.390, p = 0.05). Conclusions: New instrumentation has made the operation easier and has contributed to its spread, along with increased experience and the end of the learning curve. At the moment we consider the LAST a more anatomical and physiological surgical approach to single vessel coronary disease. (J Card Surg 7998;73:306–309)
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1540-8191.1998.tb01074.x
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  • 5
    Electronic Resource
    Electronic Resource
    Reoperative Coronary Surgery With and Without Cardiopulmonary Bypass (2000)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of cardiac surgery 15 (2000), S. 0 
    Details
    ISSN: 1540-8191
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract  Background: Reoperative coronary surgery without cardiopulmonary bypass (CPB) was analyzed to evaluate the technical profile of the patients studied and the benefit from this technique. Material and Methods: From November 21, 1994 to May 20, 1999, 166 patients had reoperative coronary surgery, 112 patients (Group A) with and 54 patients (Group B) without CPB. Median sternotomy was used in all the patients in Group A and in 13 patients in Group B. The remaining had a LAST (37 patients) or a posterolateral thoracotomy (4 patients). Results: Anastomoses per patient were 2.4 ± 0.8 in Group A and 1.1 ± 0.4 in Group B (p 〈 0.001). When a single graft was needed, CPB was not used in 82.8% of the cases. However, when more than one graft was required, CPB was not used in only 5.6% of the cases. When a single territory had to be grafted, CPB was not used in 76.6% of the patients. If two territories were grafted, only 6.8% of the patients were in Group B, whereas no patient who needed a graft in all the three territories was in Group B. Overall mortality was 3.6% cerebrovascular accident (CVA) and acute myocardial infarction (AMI) incidence were 0.6% and 1.8%, respectively, and were similar in both groups. Incidence of early major events (overall 8.4%) was not different between groups. Conclusions: The primary endpoints (mortality, CVA rate, and AMI) were similar in both groups, but patients in Group B were less complicated. However, patients in the two groups were not the same, as the technical profile was quite different. As our results were similar to those obtained in the first operation, we think that consideration of different surgical possibilities, depending on territory to be grafted, will improve the results of redo coronary surgery, making them similar to those obtained in the first operation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1540-8191.2000.tb01294.x
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  • 6
    Electronic Resource
    Electronic Resource
    Off-Pump Myocardial Revascularization Using Arterial Conduits without Cardiopulmonary Bypass (2000)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of cardiac surgery 15 (2000), S. 0 
    Details
    ISSN: 1540-8191
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract  Objective: The feasibility of myocardial revascularization via a median ster-notomy with arterial conduits, without and with cardiopulmonary bypass (CPB), was evaluated. Material and Results: From May 21, 1997, to November 30, 1999, 721 patients had myocardial revascularization without CPB via median sternotomy using at least two arterial conduits. The procedure was performed without CPB in 322 patients (Group A); the remaining 399 patients (Group B) underwent the same operation with the aid of CPB. Group A patients were older, with a higher ejection fraction and less redo than Group B. There was no early death in Group A versus nine (2.3%) patients in Group B (p 〈 0.02). Incidence of cere-brovascular accident (CVA) and acute myocardial infarction (AMI) were similar in both groups. Early major events incidences were 1.2% versus 8.0% (p 〈 0.001) in Groups A and B, respectively. Postoperative angiographic controls showed a cumulative patency rate of 98.4% and a perfect patency rate of 96.7%. After 30 months. Groups A and B showed an actuarial survival of 98.1 ± 0.7 and 96.5 ± 2.8 (p = ns) and an event-free survival of 96.6 ± 1.0 and 96.5 ± 2.8 (p = ns), respectively. Conclusion: Myocardial revascularization without CPB using arterial conduits can be accomplished with the same quality of results obtained with the use of CPB.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1540-8191.2000.tb01286.x
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  • 7
    Electronic Resource
    Electronic Resource
    Parental Interventions and the Development of the Preterm Infant (1994)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of obstetric, gynecologic and neonatal nursing 23 (1994), S. 0 
    Details
    ISSN: 1552-6909
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Objective: To review the current research on interventions to enhance the development of the preterm infant.Data Sources: Searches were conducted on Medline and CINAHL for the previous 10 years. Classic articles also were Included.Study Selection: Twenty-nine studies focusing on parental interventions were reviewed.Conclusion: Modeled interventions for the parent are effective.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1552-6909.1994.tb01851.x
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  • 8
    Electronic Resource
    Electronic Resource
    GENDER AND TASK IN THE DETERMINATION OF SPATIAL COGNITIVE PERFORMANCE (1993)
    Oxford, UK : Blackwell Publishing Ltd
    Psychology of women quarterly 17 (1993), S. 0 
    Details
    ISSN: 1471-6402
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Psychology
    Notes: A variety of sex differences in spatial cognitive performance have been documented. However, factors other than those specifically related to gender and cognition per se, such as the perceived spatial character of given tasks, may contribute to such differences. In the present experiments, spatial memory and mental image rotation tasks were presented to female and male adults. The task formats or instructions were varied to emphasize or deemphasize the spatial character of the tasks. Highly “spatial” instructions or format significantly depressed performance on spatial tasks for women but not for men. “Nonspatial” instructions or format, within which the spatial character of the task was not explicit, resulted in no significant differences between the performances of women and men on either type of task. These findings indicate that instructional or format effects relating to the purported “spatial” character of a given task may significantly influence the relative performance of women and men.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-6402.1993.tb00677.x
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  • 9
    Electronic Resource
    Electronic Resource
    Optical properties of deuterated zinc tris thiourea sulphate (1994)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 76 (1994), S. 1150-1154 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: We report measurements of the optical properties of deuterated zinc tris thiourea sulfate (d-ZTS). The material is being studied for its potential value in optical frequency conversion and electro-optic applications. The electro-optic and piezoelectric measurements along with those for the dielectric constant indicate that the figure of merit for electro-optic modulation is comparable to that of KDP. However, careful refractive index measurements along with an analysis of the nonlinear coefficient tensor show that d-ZTS will not noncritically phase match for second-harmonic generation despite the promise shown by its undeuterated analog. In addition, the acceptance angle even for critical phase matching is very small.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.357838
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  • 10
    Electronic Resource
    Electronic Resource
    Potassium channel gene therapy can prevent neuron death resulting from necrotic and apoptotic insults (2003)
    Oxford, UK : Blackwell Science Ltd
    Journal of neurochemistry 86 (2003), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Necrotic insults such as seizure are excitotoxic. Logically, membrane hyperpolarization by increasing outwardly conducting potassium channel currents should attenuate hyperexcitation and enhance neuron survival. Therefore, we overexpressed a small-conductance calcium-activated (SK2) or voltage-gated (Kv1.1) channel via viral vectors in cultured hippocampal neurons. We found that SK2 or Kv1.1 protected not only against kainate or glutamate excitotoxicity but also increased survival after sodium cyanide or staurosporine. In vivo overexpression of either channel in dentate gyrus reduced kainate-induced CA3 lesions. In hippocampal slices, the kainate-induced increase in granule cell excitability was reduced by overexpression of either channel, suggesting that these channels exert their protective effects during hyperexcitation. It is also important to understand any functional disturbances created by transgene overexpression alone. In the absence of insult, overexpression of Kv1.1, but not SK2, reduced baseline excitability in dentate gyrus granule cells. Furthermore, while no behavioral disturbances during spatial acquisition in the Morris water maze were observed with overexpression of either channel, animals overexpressing SK2, but not Kv1.1, exhibited a memory deficit post-training. This difference raises the possibility that the means by which these channel subtypes protect may differ. With further development, potassium channel vectors may be an effective pre-emptive strategy against necrotic insults.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1471-4159.2003.01880.x
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