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  • 1
    ISSN: 1432-0428
    Keywords: Growth hormone ; intermediary metabolism ; insulin sensitivity ; glucose turnover ; non-esterfied fatty acids ; ketone bodies and forearm technique
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary To elucidate the short-term actions of growth hormone on insulin sensitivity and forearm metabolism, we have studied six normal male subjects receiving a 6-h hyperinsulinaemic euglycemic clamp with and without a concomitant 4-h growth hormone infusion. When infused, serum growth hormone rose to 25±4 mU/l and during administration of insulin serum insulin increased by 11±1 mU/l. During euglycemic clamp, administration of growth hormone decreased forearm glucose uptake after 180 min and onward (240 min 0.216±0.031 vs 0.530±0.090 mg/100 ml/min, p〈0.05). Glucose infusion rate (240 min 2.83±0.24 vs 4.35±0.28 mg·kg−1· min#x2212;1, p〈0.05) and glucose disposal rate (240 min 3.57±0.17 vs 4.00±0.15 mg·kg−1· min−1, p〈0.05) also decreased. Growth hormone persistently increased hepatic glucose production after 120 min. After 210 min, all circulating lipid intermediates increased slightly. The decrease in forearm glucose uptake and glucose infusion rate and the increase in hepatic glucose production was observed before there was any detectable increase in circulating levels and forearm uptake of lipid intermediates. These data suggest that growth hormone induces insensitivity to insulin in liver, muscle and fat after 120, 180 and 210 min respectively. The early effects of growth hormone on glucose metabolism seems independent of changes in the rate of lipolysis.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-0428
    Keywords: Key words Insulin therapy, diabetes education, hypoglycaemia, ketoacidosis, hospitalisation, blood glucose monitoring, urine glucose monitoring, cost-benefit-analysis.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In a prospective controlled trial the effects of a 5-day in-patient treatment and teaching programme for Type 1 (insulin-dependent) diabetes mellitus on metabolic control and health care costs were studied in Moscow. Two different intervention programmes were compared, one based upon urine glucose self-monitoring (UGSM, n =61) and one using blood glucose self-monitoring (BGSM, n =60). Follow-up was 2 years. A control group (n =60) continued the standard treatment of the Moscow diabetes centre and was followed-up for 1 year. Costs and benefits with respect to hospitalizations and lost productivity (according to average wage) were measured in November 1992 roubles (Rb.), with respect to imported drugs and test strips in 1992 German marks (DM). In the intervention groups there were significant decreases of HbA1 values [UGSM: 12.5 % before, 9.4 % after 1 year, 9.2 % after 2 years (p〈0.0001); BGSM: 12.6 % before, 9.3 % after 1 year, 9.2 % after 2 years (p〈0.0001) compared to no change in the control group (12.2 % before, 12,3 % after 1 year)], and of the frequency of ketoacidosis. The frequency of severe hypoglycaemia was comparable between the UGSM (10 cases during 2 years), BGSM (10 cases during 2 years), and the control group (8 cases during 1 year). In the combined intervention groups, there were significant decreases of hospital days per patient per year (12.1 during the year before, 1.0 year one after, 3.6 year two after, p〈0.005), and of additional sick leave days (16.6 during the year before, 2.4 year one, 7.8 year two after, p〈0.01), whereas these parameters remained unchanged in the control group. The initial costs of the intervention were outweighed by this subsequent reduction in hospitalizations and lost productivity. Net savings totalled up to 14 400 Rb./patient within 2 years. Patients of the intervention groups were told to discontinue drugs which were not indicated and/or ineffective (clofibrate, pentoxifylline, calcium dobesilate). This caused estimated average savings of DM 240 per patient per year. Costs of test strips for UGSM were DM 180 per patient per year; for BGSM they were estimated to lie between DM 370 and DM 550 per patient per year, depending on the frequency of measurements. In conclusion, the intervention led to an improvement of metabolic control and saved resources for health care by reducing hospitalizations and sick leave days. When UGSM is used, costs of test strips are approximately outweighed by discontinuing ineffective drugs. [Diabetologia (1994) 37: 170–176]
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1432-1041
    Keywords: Tolbutamide ; diabetes mellitus ; non-insulin dependent ; pharmacokinetics ; pharmacodynamics ; glucose ; insulin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary It is uncertain how the hypoglycaemic effect of sulphonylureas varies with drug concentration in patients with non-insulin-dependent diabetes mellitus. The interrelationship of tolbutamide dosage and concentration, and glucose and insulin concentrations were therefore examined in 54 out-patients (the observational group) and in 20 patients studied under controlled conditions (the experimental group). In the observational group, tolbutamide concentration depended significantly on the daily dose, time from dose to sampling, body weight, and age. Blood glucose and insulin concentration were related, but were independent of tolbutamide concentration. In the experimental group, peak, but not pre-dose, tolbutamide concentration, depended on dose and on body mass index. Fasting and maximum post-prandial blood glucose concentration were positively correlated with maximum tolbutamide concentration, probably because tolbutamide dosage was highest in those with the poorest response. In the subset with a fasting blood glucose concentration of less than 8 mmol·l−1, neither glucose nor insulin concentrations depended significantly on tolbutamide concentrations. Tolbutamide concentration does not directly determine hypoglycaemic response in outpatients, and therapeutic monitoring of drug concentrations would not improve the management of such patients.
    Type of Medium: Electronic Resource
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