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  • 1
    Electronic Resource
    Electronic Resource
    The state of leukocyte adhesiveness/aggregation in the peripheral blood is more sensitive than the white blood cell count for the detection of acute mental stress
    Amsterdam : Elsevier
    Journal of Psychosomatic Research 36 (1992), S. 37-46 
    Details
    ISSN: 0022-3999
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine , Psychology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0022-3999(92)90112-F
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  • 2
    Electronic Resource
    Electronic Resource
    Corynebacterium CDC Group A-4 native valve endocarditis (1991)
    Springer
    European journal of clinical microbiology & infectious diseases 10 (1991), S. 1056-1057 
    Details
    ISSN: 1435-4373
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A patient with endocarditis caused byCorynebacterium CDC Group A-4 is described. This is the first case in the literature of endocarditis caused by this bacteria, and is unique in that the patient was immune competent and the infection occurred on a native valve. This case illustrates that corynebacteria cannot be considered a contaminant and that the exact pathogen should be identified.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01984928
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  • 3
    Electronic Resource
    Electronic Resource
    Effect of misoprostol and cimetidine on gastric cell turnover (1985)
    Springer
    Digestive diseases and sciences 30 (1985), S. 133S 
    Details
    ISSN: 1573-2568
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effects of misoprostol 200 μg q.i.d. and cimetidine 300 mg q.i.d. on gastric cell turnover were investigated in duodenal ulcer patients before and after four weeks of therapy. Endoscopic biopsies were incubated with3H-thymidine. Glandular column length (number of cells per column) and the number of labelled cells per column were determined by autoradiography. There were no significant treatment effects on column length of the gastric pits of either the antrum or fundus. However, misoprostol and cimetidine had opposing effects on cell turnover. Misoprostol significantly decreased the number of labelled cells in antral (P〈0.01) and fundic (P〈0.001) gastric pits. However cimetidine significantly increased (P〈0.01) the number of labelled cells in antral and fundic columns. The increased gastric cell turnover caused by cimetidine may contribute to its activity in peptic ulcer disease. The decreased cell turnover induced by misoprostol does not appear to be a mechanism responsible for its well-established cytoprotective activity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01309399
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  • 4
    Electronic Resource
    Electronic Resource
    Epidemiology of achalasia in central israel rarity of esophageal cancer (1993)
    Springer
    Digestive diseases and sciences 38 (1993), S. 1920-1925 
    Details
    ISSN: 1573-2568
    Keywords: achalasia ; epidemiology ; esophageal cancer
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The epidemiology of achalasia was studied in a predominantly urban, Jewish population of approximctely 1.3 million, in central Israel, during the years 1973–1983. One hundred sixty-two proven cases were collected, representing all known patients with achalasia in the study area. There were no gender differences. The majority of cases were diagnosed within two years of onset of symptoms, although the median delay in diagnosis was 4.4±5.3 years. The disease was rare in the first two decades of life. The prevalence (in 1983) in the first two decades was 0.7/105 rising to 36.2/105 above age 70. The mean annual incidence in the years 1973–1978 was 0.8/105. It rose slightly to a mean annual incidence of 1.1/105 in the years 1979–1983. The prevalence of the disease in 1973 and 1983 was 7.9/105 and 12.6/105, respectively. The age-adjusted prevalence in 1973 was higher in Asian and African born Jews as compared to those born in Europe, America, or Israel. This difference disappeared by the year 1983. No case of cancer of the esophagus was found among our patients. This may be due to the nonselected, regional nature of our series or to the effects of earlier therapy of achalasia in recent decades.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01296119
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  • 5
    Electronic Resource
    Electronic Resource
    Increased serum iron and iron saturation without liver iron accumulation distinguish chronic hepatitis C from other chronic liver diseases (1994)
    Springer
    Digestive diseases and sciences 39 (1994), S. 2656-2659 
    Details
    ISSN: 1573-2568
    Keywords: hepatitis ; iron ; hemochromatosis ; HCV ; HBV ; chronic liver disease
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract One hundred twenty-three patients with chronic liver diseases of various etiologies were evaluated for their iron status. The patients were divided into four distinct groups: chronic hepatitis C (63), chronic hepatitis B (14), B + C (3) and nonviral chronic liver diseases (43). In 107 patients (87%) the chronic liver disease was confirmed by biopsy. Mean serum iron (±sd) levels in the above four groups were: 166 ± 62, 103 ± 52, 142 ± 48, and 115 µg/dl; iron-binding capacity was 346 ± 80, 325 ± 72, 297 ± 27, and 374 ± 75 µg/dl, and iron saturation 50 ± 18, 32 ± 16, 48 ± 16, and 28 ± 10%, respectively. Serum ferritin, increased in all four groups, was highest in HCV; however, no evidence of hepatic iron accumulation could be found in any of the patients. There were no significant differences in liver function parameters measured in the four groups. We conclude that serum iron, iron saturation, and ferritin are increased in patients with hepatitis C in comparison to hepatitis B or other nonviral, nonhemochromatotic liver diseases. The increased iron status in hepatitis C patients is not manifested by increased liver iron. Awareness of these distinct features of chronic hepatitis C is essential in the diagnosis and treatment of chronic liver diseases.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02087705
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  • 6
    Electronic Resource
    Electronic Resource
    Increased turnover of intrahepatic bile ducts induced by bromobenzene (1995)
    Springer
    Digestive diseases and sciences 40 (1995), S. 730-733 
    Details
    ISSN: 1573-2568
    Keywords: bromobenzene ; bile ducts ; streaming ; liver
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Intrahepatic bile duct epithelium consists of two kinetic compartments: a progenitor (P) and a functional (Q) compartment. Hitherto bromobenzene was known to poison only hepatocytes in the third acinus zone. The present experiment aims to demonstrate that bromobenzene affects also bile duct turnover. Thirty male adult rats received one intraperitoneal injection of bromobenzene and were sacrificed in groups of five at the following times: 1, 2, 3, 4, 7, and 14 days. They received [3H]thymidine 1 hr before sacrificing. Autoradiography was done. Bile ducts were evaluated in all portal tracts of the section. The number of epithelial cells in each duct cross section was counted and defined as bile duct class, which is roughly proportional to bile duct size. In each cross section the number of labeled cells was counted. Initially the labeling index was 0.76±0.3%. By day 3, it reached a peak of 4.1±1.1%, and then declined to its initial level. Following bromobenzene poisoning, hepatocyte and bile duct epithelia turn over in the same fashion. In both, labeling index and progenitor compartment size initially rise and return by the end of the first week to their initial level. We propose that bile duct epithelia and hepatocytes originate in one determined uncommitted stem cell that resides in the Henring duct. Bromobenzene-induced necrosis triggers proliferation of progenitors in both cell lineages, as well as in the stem cell itself.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02064969
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  • 7
    Electronic Resource
    Electronic Resource
    Roles of cyclin D1 and related genes in growth inhibition, senescence and apoptosis (1999)
    Springer
    Apoptosis 4 (1999), S. 213-219 
    Details
    ISSN: 1573-675X
    Keywords: Apoptosis ; cyclin D1 ; growth inhibition ; senescence.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract It is now apparent that apoptosis is closely linked to the control of cell cycle progression. During the G1 to S progression, cyclin D1, p53, and the cyclin dependent kinase inhibitors p21WAF1 and p27kip1 can play roles in induction of apoptosis. During the G2 and M phases, premature activation of Cdk1 can cause cells to enter mitotic catastrophe, which results in apoptosis. In this review we focus on factors acting during G1 and S, particularly cyclin D1, and their effects on cell growth, senescence and apoptosis. We emphasize that cyclin D1 can have diverse effects on cells depending on its level of expression, the specific cell type, the cell context and other factors. Possible mechanisms by which cyclin D1 exerts these diverse effects, via cyclin dependent kinase-dependent and -independent pathways, are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1009618824145
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  • 8
    Electronic Resource
    Electronic Resource
    Janus faces of ras: anti or pro-apoptotic? (1999)
    Springer
    Apoptosis 4 (1999), S. 383-388 
    Details
    ISSN: 1573-675X
    Keywords: Apoptosis ; cell cycle ; proliferation ; ras.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Cell population homeostasis is a balance between cell proliferation on one hand and the rate of cell loss on the other hand. Normal tissue homeostasis requires the physiological deletion of cells by activation of apoptosis, a genetically determined program of autonomous cell death. ras is most probably the most important oncogene in human cancer. It is mutated in 30% of all tumors especially those of the gastrointestinal tract. In regulating apoptosis ras has many faces. it has both negative and positive effects depending on the stimulation and cell type. The responses of cells to ras signaling depends on the level of Ras expression, the activity of various pathways, and which of the cell cycle check points are functioning. New farnesyl transferase inhibitors and non-steroidal anti-inflammatory compounds may provide a new strategy for novel therapeutic modalities in the treatment of human cancer. The first clinical trials have been initiated, preliminary results are promising, although no firm results are yet available.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1009651406017
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  • 9
    Electronic Resource
    Electronic Resource
    Adult onset Still's disease (1989)
    Springer
    Clinical rheumatology 8 (1989), S. 339-344 
    Details
    ISSN: 1434-9949
    Keywords: Adult Onset Still's Disease ; Liver Function Tests
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Three patients with adult onset of Still's disease are presented. Common early findings were: septic fever, polyarthralgia, leukocytosis, neutrophilia and elevated sedimentation rate. All of them had abnormal liver function tests which returned to normal values following corticosteroid therapy. It is proposed that hepatic abnormalities in adult onset of Still's disease reflect the basic disease process.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02030346
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