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  • 1
    Electronic Resource
    Electronic Resource
    The E3 ligase HACE1 is a critical chromosome 6q21 tumor suppressor involved in multiple cancers (2007)
    [s.l.] : Nature Publishing Group
    Nature medicine 13 (2007), S. 1060-1069 
    Details
    ISSN: 1546-170X
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Transformation and cancer growth are regulated by the coordinate actions of oncogenes and tumor suppressors. Here, we show that the novel E3 ubiquitin ligase HACE1 is frequently downregulated in human tumors and maps to a region of chromosome 6q21 implicated in multiple human cancers. Genetic ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nm1621
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  • 2
    Electronic Resource
    Electronic Resource
    The potential for antitumor vaccination in acute myelogenous leukemia (1998)
    Springer
    Journal of molecular medicine 76 (1998), S. 80-93 
    Details
    ISSN: 1432-1440
    Keywords: Key words Acute myelogenous leukemia ; Cancer vaccines ; Immunotherapy ; Costimulation ; Cytokines
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  While many advances have been made in the treatment of patients with cancer, significant challenges that remain include tumor cell resistance and the toxicity associated with currently used intensive chemotherapeutic regimens. This is particularly true for patients with acute myelogenous leukemia (AML). Most patients with AML usually are able to achieve complete remission, but only a minority obtain long-term survival. In addition, much of the success achieved has been due to escalation of chemotherapeutic dosing and hematopoietic stem cell transplantation. There is thus a great need for improved therapies which would ideally be able to circumvent drug resistance and more specifically target leukemic cells. Advances in immunobiology over the past century have led to new hope for the development of immune-mediated vaccine therapies for patients with cancer. This review focuses on the development of vaccine approaches for treatment of AML and some of the potential advantages and problems.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001090050195
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  • 3
    Electronic Resource
    Electronic Resource
    Multidrug resistance gene expression is controlled by steroid hormones in the secretory epithelium of the uterus (1990)
    New York, NY [u.a.] : Wiley-Blackwell
    Molecular Reproduction and Development 25 (1990), S. 101-109 
    Details
    ISSN: 1040-452X
    Keywords: mdr gene ; Pregnancy ; In situ hybridization ; Development ; Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Notes: The multidrug resistance (mdr) gene family has been shown to encode a membrane glycoprotein, termed the P-glycoprotein, which functions as a drug efflux pump with broad substrate specificity. This multigene family is expressed in a tissue-specific fashion in a wide variety of normal and neoplastic tissues. The regulation of mdr gene expression in normal tissues is not understood. We have recently shown that mdr mRNA and the P-glycoprotein increases dramatically in the secretory luminal and glandular epithelium of the gravid murine uterus. This observation has suggested that mdr gene expression in the uterus is controlled by the physiologic changes associated with pregnancy. This report now demonstrates that mdr mRNA and P-glycoprotein are induced at high levels in the uterine secretory epithelium by the combination of estrogen and progesterone, the major steroid hormones of pregnancy. This regulation of mdr gene expression in the uterus does not require any other contribution from the fetus or placenta. The data indicate that this gene locus is hormonally responsive to estrogen and progesterone in the uterine secretory epithelium, suggesting an important and physiologically regulated role during pregnancy.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/mrd.1080250202
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  • 4
    Electronic Resource
    Electronic Resource
    Role of colony stimulating factor-1 (CSF-1) and other lympho-hematopoietic growth factors in mouse pre-implantation development (1991)
    New York, NY : Wiley-Blackwell
    BioEssays 13 (1991), S. 535-540 
    Details
    ISSN: 0265-9247
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: Mouse pre-implantation development appears to be under the control of paracrine and autocrine growth factors. The epithelium of the oviduct and the uterus together, with the population of macrophages and lymphocytes present in the reproductive tract from the onset of pregnancy, are thought to be the major sources of paracrine growth factors targeted to the developing embryos. Some of the growth factors are synthesized by both uterine epithelial cells and activated lympho-hematopoietic cells, suggesting a partial overlap of the regulatory signals used by the reproductive and lympho-hematopoietic systems. Such growth factors may be the long sought-after mediators of the synchrony between the pre-implantation embryo and the sex-steroid hormone-induced changes in the uterus.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bies.950131007
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