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  • 1
    Electronic Resource
    Electronic Resource
    Phosphorylation by aurora kinase A induces Mdm2-mediated destabilization and inhibition of p53 (2004)
    [s.l.] : Nature Publishing Group
    Nature genetics 36 (2004), S. 55-62 
    Details
    ISSN: 1546-1718
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Aurora kinase A (also called STK15 and BTAK) is overexpressed in many human cancers. Ectopic overexpression of aurora kinase A in mammalian cells induces centrosome amplification, chromosome instability and oncogenic transformation, a phenotype characteristic of loss-of-function mutations of p53. ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/ng1279
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  • 2
    Electronic Resource
    Electronic Resource
    Cross-reactive T-cell proliferative responses to V3 peptides corresponding to different geographical HIV-1 isolates in HIV-seropositive individuals (1996)
    Springer
    Journal of clinical immunology 16 (1996), S. 115-124 
    Details
    ISSN: 1573-2592
    Keywords: AIDS ; HIV-1 ; V3-loop ; synthetic peptides ; T-cell proliferation ; antibody response ; cross-reactivity ; cell-mediated immunity ; vaccine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We have investigated the proliferative response of peripheral blood mononuclear cells from individuals infected with human immunodeficiency virus type 1 (HIV-1) to synthetic peptides from the third variable loop region (V3) in the envelope protein gp120. We tested a total of 14 peptides, corresponding to 14 HIV-1 isolates belonging to four geographical locations (clades U, A, B, and D). Although differences in relative level of responses exist between individual peptides and patients, the proliferation in response to all 14 V3 peptides was significantly greater than that to unrelated control peptides. Additionally, we observed that proliferative responses of blood cells from the 10 HIV-seropositive individuals studied from the clade B region to peptides from within clades U, A, B, and D were not significantly different, indicating the cross-reactive nature of the V3-specific cell-mediated immune responses. Even though the majority of patients also exhibited antibody responses against several V3 peptides, serum samples from 50% of clade B patients exhibited antibody cross-reactivity, while proliferative responses to V3 peptides from more than one clade were observed in 80% of patients. Importantly, in two patients, decreased CD4+ cell numbers, an important surrogate marker of disease progression, significantly correlated with loss of V3 peptide-specific proliferative responses but not antibody responses. These results have important implications toward evaluating the utility of V3 peptides for designing therapeutic and/or vaccine reagents against HIV-1.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01540958
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  • 3
    Electronic Resource
    Electronic Resource
    RNA polymerase complexes from mengovirus infected cells (1972)
    Springer
    Archives of virology 38 (1972), S. 17-28 
    Details
    ISSN: 1432-8798
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Two RNA polymerase complexes were isolated from mengovirus-infected baby hamster kidney cells. One is designated the light polymerase complex and the other is termed the heavy polymerase complex. The two polymerase complex fractions have different properties. The light polymerase complex synthesizes a 20 S RNase-resistant RNA which migrates slower on agarose gels than doubl-estranded RNA. The heavy complex product contains replicative intermediates and virion RNA. No virion RNA synthesis by the light complex was detected. The heavy complex product is more difficult to deproteinize and incorporates3H-UTP longer than the light complex.3H-RNA-containing particles which sedimented with mengovirus in both sucrose and cesium chloride gradients were detected in the heavy complex product.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01241352
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  • 4
    Electronic Resource
    Electronic Resource
    Expression of epidermal growth factor receptor and associated glycoprotein on cultured human brain tumor cells (1986)
    New York, N.Y. : Wiley-Blackwell
    Journal of Cellular Biochemistry 32 (1986), S. 1-10 
    Details
    ISSN: 0730-2312
    Keywords: epidermal growth factor ; brain tumors ; cell surface glycoproteins ; Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: The expression of epidermal growth factor (EGF-R) in normal glial and glioma cells grown in culture was examined by using several independent assays. Immunoprecipitation with the monoclonal antibody R1 of extracts from metabolically labeled glial and glioma cells revealed a protein of Mr ∼ 170,000, with a migration in sodium dodecyl sulfate-polyacrylamide gels identical to the EGR-R of A431 epidermal carcinoma cells. Furthermore, in the majority of glioma extracts, a protein of Mr ∼ 190,000 was specifically immunoprecipitated by this antibody. Similar results were obtained by immunoblotting with a second antibody directed against a synthetic peptide in the sequence of the V-erb-B oncogene. In cell lines expressing both proteins, each was specifically phosphorylated on tyrosine in immune complex kinase assays. The majority of glioma cells bound between 40,000 to 80,000 125I-labeled epidermal growth factor molecules per cell. These results suggest that the expression of EGF-R is common in cultured human glioma cells. In addition, a structurally related protein, is expressed in some of these cells.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcb.240320102
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