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  • 1
    Electronic Resource
    Electronic Resource
    Concentrations of temafloxacin in serum and bronchial mucosa (1990)
    Springer
    European journal of clinical microbiology & infectious diseases 9 (1990), S. 432-434 
    Details
    ISSN: 1435-4373
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The bronchial mucosal concentrations of temafloxacin hydrochloride were determined in specimens obtained at fibreoptic bronchoscopy and compared with simultaneous serum concentrations. The 18 patients studied were given an oral dose of 400 mg b.i.d. for three days to achieve steady state levels. The mean serum concentration was 6.9 mg/l (SD 2.5 mg/l) and the mean bronchial mucosal concentration 12.2 mg/kg (SD 4 mg/kg). The mucosal levels exceeded those required to inhibit most of the common respiratory pathogens, includingStreptococcus pneumoniae andPseudomonas aeruginosa. These data support the use of temafloxacin for therapy of bronchial infections.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01979477
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  • 2
    Electronic Resource
    Electronic Resource
    hPTH 1–34 treatment of osteoporosis with added hormone replacement therapy: Biochemical, kinetic and histological responses (1991)
    Springer
    Osteoporosis international 1 (1991), S. 162-170 
    Details
    ISSN: 1433-2965
    Keywords: Hormone replacement therapy ; hPTH 1–34 treatment ; Osteoporosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Twelve patients with vertebral fracture osteoporosis were recruited into a trial of treatment with hPTH 1–34 by daily injection for 1 year combined (from the 5th month) with an anti-resorptive agent (oestrogen, n=9; nandrolone, n=3). Treatment outcomes were monitored by biochemical and radiotracer measurements together with histomorphometry of transiliac biopsies before and at the end of treatment following double in vivo pre-labelling with demethylchlortetracyc-line. Indices of whole body bone formation, obtained from the analysis of85Sr data, showed substantial increases (P〈0.005) for all three indices measured) while biochemical (hydroxyproline) and kinetic measurements of bone resorption showed modest and equivocal changes only. As a result calcium balance improved. Gastrointestinal calcium absorption showed a tendency to improve, while urine calcium decreased; but these changes were statistically not significant except for radiocalcium absorption in the oestrogen treated subgroup. Histomorphometry revealed substantial increases in cancellous bone volume as reported previously with hPTH 1–34 given alone. However, iliac (as distinct from whole body) indices related to bone formation and resorption appeared to have returned towards pre-treatment values by the time of the second biopsy under the influence of the anti-resorptive agent given with the hPTH 1–34. It is confirmed that hPTH 1–34 therapy can increase iliac cancellous bone mass (as well as spinal cancellous bone mass as reported earlier) without a long-term increment in whole body bone resorption, providing the hPTH is combined with an anti-resorptive agent.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01625448
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  • 3
    Electronic Resource
    Electronic Resource
    Evidence for priming and inhibitory effects of glucose on insulin secretion from isolated islets of langerhans (1980)
    Springer
    Diabetologia 18 (1980), S. 417-421 
    Details
    ISSN: 1432-0428
    Keywords: Biphasic insulin secretion ; perifused islets of Langerhans ; regulation by glucose ; potentiation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Biphasic insulin secretion from perifused rat islets of Langerhans was affected in three ways by the islet glucose environment prior to stimulation, (i) The secretory response to glucose was diminished if the basal concentration of glucose in the medium was reduced from 5.5 to 2.7 mmol/l for 2 h prior to stimulation. First phase secretion was affected more than the second, (ii) Secretion was potentiated if islets had been previously exposed to a stimulatory concentration of glucose of 22.2 mmol/l. Again first phase secretion was particularly affected and there was a positive correlation between the magnitude of the secretory response and the duration of the initial stimulus, (iii) In contrast, both phases of secretion were proportionately reduced if islets had been previously exposed to stimulatory concentrations of glucose of 8.3 mmol/l.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00276824
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  • 4
    Electronic Resource
    Electronic Resource
    The priming effect of glucose on insulin secretion from isolated islets of Langerhans (1981)
    Springer
    Diabetologia 21 (1981), S. 230-234 
    Details
    ISSN: 1432-0428
    Keywords: Biphasic insulin secretion ; perifused islets ; glucose priming ; mannoheptulose ; glyceraldehyde ; calcium ; deuterium oxide ; cyclic AMP ; adrenaline
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Biphasic insulin secretion from perifused rat islets of Langerhans was enhanced if islets had previously been stimulated with glucose 16.6 mmol/l. The priming effect of glucose was reduced if mannoheptulose (16.6 mmol/l), deuterium oxide (D2O; 98% v/v) or adrenaline (10μmol/l) was included in the medium during the initial stimulation period, or if Calcium was omitted. Glyceraldehyde (16.6 mmol/l) but not theophylline (5 mmol/l) could substitute for glucose during the initial stimulation and make islets more responsive to subsequent stimulation. The results suggest that the priming effect of glucose on insulin secretion may be related to 1) glucose metabolism and 2) Ca fluxes in the B cell and the consequent activation of the microtubular system. Neither the generation of intracellular cyclic AMP nor the release of insulin per se appears to be involved in the priming process.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00252659
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  • 5
    Electronic Resource
    Electronic Resource
    Attenuation of the pancreatic beta cell response to a meal following hypoglycaemia in man (1980)
    Springer
    Diabetologia 18 (1980), S. 297-300 
    Details
    ISSN: 1432-0428
    Keywords: Hypoglycaemia ; beta-cell function ; C-peptide ; insulin secretion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The plasma concentration of C-peptide, insulin (IRI) and glucose was measured in 9 healthy subjects during insulin-induced hypoglycaemia followed by a meal. Identical observations were made in the same subjects after an equivalent period of fasting without hypoglycaemia (control study). Endogenous secretion of insulin was suppressed following administration of exogenous insulin and this persisted long after the blood glucose concentration had returned to normal. After the meal the mean blood glucose rose to a peak of 8.4±0.3 mmol/l (mean ± SEM) at 60 min and was still raised at 7.5±0.3 mmol/l at 120 min, compared with a peak value of only 5.1±0.2 mmol/l at 30 min after the meal in the control study. Following hypoglycaemia the mean plasma IRI rose from 8.3±1.3 mU/l to a delayed peak of 81.6±12.7 mU/l at 60 min and was 123.5±14 mU/l at 120 min post-prandially, compared with a peak of 72.4±0.5 mU/l at 30 min after the meal in the control study. Acute hypoglycaemia may thus induce an abnormal pattern of insulin secretion in response to a meal, with impaired carbohydrate tolerance in normal subjects.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00251009
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  • 6
    Electronic Resource
    Electronic Resource
    Book review (1984)
    Springer
    Journal of inherited metabolic disease 7 (1984), S. 45-45 
    Details
    ISSN: 1573-2665
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01805622
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  • 7
    Electronic Resource
    Electronic Resource
    Pharmacokinetics and tissue penetration of orally administered pefloxacin (1987)
    Springer
    European journal of clinical microbiology & infectious diseases 6 (1987), S. 521-524 
    Details
    ISSN: 1435-4373
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The pharmacokinetics of the quinolone pefloxacin were determined following a 400mg oral dose given to each of six male volunteers. Concentrations were determined in serum and urine by high-performance liquid chromatography, and in cantharidin-induced inflammatory fluid by a microbiological assay. The mean peak serum level of 6.6 μg/ml was attained rapidly 0.8 h after administration. The mean serum elimination half-life was 11.6 h. Inflammatory fluid was penetrated quickly with a mean peak level of 3.9 μg/ml occurring at 2.4 h. Pefloxacin was excreted in the urine as the parent compound and its two metabolites, norfloxacin and pefloxacin N-oxide (24h urinary recovery being 8.0%, 12.0% and 13.1% respectively of the dose). This study suggests that a twice or possibly once daily dosage may be sufficient to treat systemic infections caused by susceptible pathogens. Once daily dosing should be sufficient for urinary tract infections.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02014239
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  • 8
    Electronic Resource
    Electronic Resource
    Tissue penetration and pharmacokinetics of lomefloxacin following multiple doses (1989)
    Springer
    European journal of clinical microbiology & infectious diseases 8 (1989), S. 168-170 
    Details
    ISSN: 1435-4373
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The pharmacokinetics of lomefloxacin were studied after three days of oral administration of 400 mg/day lomefloxacin. Following the final dose the concentrations in serum, urine and cantharidin-induced inflammatory fluid were measured by a microbiological assay. The mean peak serum level was 4.9 mg/l at a mean time of 0.8 h. The mean serum elimination half-life was 6.2 h. The mean maximum inflammatory fluid level attained was 3.2 mg/l at 2.7 h. Urinary recovery accounted for the greater part of lome-floxacin's elimination.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01963906
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  • 9
    Electronic Resource
    Electronic Resource
    Intraperitoneal penetration of cefpirome (1989)
    Springer
    European journal of clinical microbiology & infectious diseases 8 (1989), S. 556-558 
    Details
    ISSN: 1435-4373
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Twenty-six patients undergoing elective gastro-intestinal surgery received a 1 g intravenous dose of cefpirome before operation. Serum and peritoneal fluid samples, obtained 0.5–7.6 h following administration, were assayed for cefpirome by a microbiological assay. The serum half-life of cefpirome was 2.1 h. The mean concentration of cefpirome in peritoneal fluid 0–2 h after administration was 44.4 µg/ml. The half-life of cefpirome in peritoneal fluid was 2 h, with mean concentrations of 〉10 µg/ml measured 6 h after administration. The mean percentage of intraperitoneal penetration of cefpirome over the study period was 97.7 %. The therapeutic implications are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01967480
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