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  • 1
    Electronic Resource
    Electronic Resource
    EVIDENCE FOR CIRCULATING IMMUNE COMPLEXES IN ERYTHEMA NODOSUM AND EARLY SARCOIDOSIS (1976)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 278 (1976), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1976.tb47032.x
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  • 2
    Electronic Resource
    Electronic Resource
    Change of insulin dosage, circulating free and bound insulin and insulin antibodies on transferring diabetics from conventional to highly purified porcine insulin (1978)
    Springer
    Diabetologia 14 (1978), S. 99-105 
    Details
    ISSN: 1432-0428
    Keywords: Serum free insulin ; insulin antibody ; binding constants ; highly purified porcine insulin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Fifty-eight patients on long term conventional mainly bovine insulins have been transferred to highly purified porcine insulin preparations. There was an overall reduction of 22% in daily insulin dosage and improved diabetic control as shown by decreased blood glucose concentration. Increased concentrations of serum free insulin and falls in serum bound insulin levels were also found. There were reductions in the serum binding capacities and affinity constants on changeover from conventional to highly purified insulin due to a combination of the effects of differential conventional/purified porcine binding and the substitution of a low antigenicity insulin. However, 12 of the patients receiving higher doses of insulin experienced marked hypoglycaemic reactions immediately on insulin change-over despite initial dosage reductions of 30% and prior to any changes in antibody characteristics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01263447
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  • 3
    Electronic Resource
    Electronic Resource
    How does glucose regulate the human pancreatic A cell in vivo? (1984)
    Springer
    Diabetologia 26 (1984), S. 203-207 
    Details
    ISSN: 1432-0428
    Keywords: Pancreatic A cell ; paracrine ; glucose clamp ; C-peptide
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary To investigate the mechanism whereby changes in plasma glucose level alter human pancreatic A-cell activity in vivo, A-cell activity was determined during manipulation of plasma glucose and pancreatic B-cell activity by insulin and glucose infusions. A-cell activity (the acute immunoreactive glucagon response to intravenous arginine, 0–10 min) rose from 482±125 to 968±191 pg · ml-1 · 10 min-1 (mean±SEM) when the plasma C-peptide level (a measure of B-cell activity) was suppressed from 2164±365 to 872±162 pg/ml by an insulin infusion at euglycaemia (employing the glucose clamp technique) in six normal subjects. Raising plasma glucose to 6.7 mmol/l during the same insulin infusion returned mean C-peptide (2688±581 pg/ml) and the acute glucagon response to arginine (447±146 pg · ml-1 · 10 min-1) close to basal levels. Individual changes in the acute glucagon response to arginine followed the C-peptide changes. The mean change in the acute glucagon response to arginine per unit change in plasma glucose (-191±36) was similar to that seen when plasma glucose was raised to twice basal levels in six different subjects without an insulin infusion (-159±45). This suggests that, when plasma glucose is raised to about twice basal level in vivo, the major factor in suppressing A-cell activity is the concurrent change in B-cell activity rather than direct effects of glucose or circulating insulin on the A cell.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00252408
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  • 4
    Electronic Resource
    Electronic Resource
    Serum free insulin concentrations during the treatment of diabetic coma and precoma with low dose intramuscular insulin (1977)
    Springer
    Diabetologia 13 (1977), S. 475-480 
    Details
    ISSN: 1432-0428
    Keywords: Diabetic coma ; precoma ; low-dose intramuscular insulin ; free insulin ; steady-state gel filtration
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Fifty patients in diabetic coma or precoma, 33 of whom had previously received insulin and had circulating insulin antibodies, were studied during treatment with a low-dose intramuscular insulin regime. In the presence of insulin antibodies, serum free insulin was separated from bound insulin by steady-state gel filtration. The initial mean serum free insulin concentration in the group of patients without insulin antibodies was 9 mU/l, 1 to 2 hours after intramuscular therapy it had risen to 22 mU/l, and after 7 to 8 hours to 73 mU/l. The corresponding concentrations for the group with insulin antibodies were 13, 23 and 74 mU/l. No relationship was found between the concentrations of serum free insulin attained and the age of the patients, their initial degree of acidosis, dehydration, and systolic blood pressure, the insulin antibody characteristics of their sera, nor the rate of decline of the blood glucose.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01234499
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  • 5
    Electronic Resource
    Electronic Resource
    Reduced coxsackie antibody titres in Type 1 (insulin-dependent) diabetic patients presenting during an outbreak of coxsackie B 3 and B 4 infection (1982)
    Springer
    Diabetologia 22 (1982), S. 426-429 
    Details
    ISSN: 1432-0428
    Keywords: Type 1 diabetes ; virus ; Coxsackie B 4 ; antibody titres
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The potential role of antecedent viral infection in the pathogenesis of Type 1 (insulin-dependent) diabetes was investigated by measuring antibody titres to several viruses in serum obtained at the time of diagnosis of diabetes. An outbreak of Coxsackie B 4 infection folio wed by a wave of Coxsackie B 3 and B 5 infections occurred in Seattle during the time viral serology was obtained in the diabetic patients. Antibody titres to Cocksackie B 5 and Influenza A and B viruses were comparable in diabetics and matched control subjects, but antibody titres to Cocksackie B 3 and B 4 were lower in the diabetics and a low antibody titre to Coxsackie B 3/B 4 was associated with a significantly increased relative risk of diabetes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00282584
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    Paper (German National Licenses)
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