ISSN:
1432-0428
Keywords:
Paracrine
;
insulin secretion
;
glucagon secretion
;
glucagon antibodies
;
arginine
;
glucose
;
rat
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary The effects of glucose and arginine on insulin secretion in the presence of glucagon antibodies were investigated in rats in vivo. In contrast to controls, animals given glucagon antibodies showed an inhibition of arginine-stimulated (p 〈 0.001), but not glucose-stimulated, insulin secretion. That these effects were not due to incomplete neutralisation of endogenous glucagon is evidenced by the presence of large antibody excess throughout the duration of the experiments. Both the glucagonotropic effect of arginine (319 ± 60ng/l, p 〈 0.01) and the insulinotropic effect of exogenous glucagon (8.3 ± 0.8 μg/l, p 〈 0.001) were demonstrable under our experimental conditions in the absence of exogenous glucagon antibodies. These observations suggest that different mechanisms are involved in the stimulation of insulin release by arginine and by glucose, and that glucagon may play an important physiological role in the mediation and regulation of insulin secretion by secretogogues, such as arginine.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00280888
Permalink
