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  • 1
    Electronic Resource
    Electronic Resource
    bcl-2 proto-oncogene and Epstein–Barr virus latent membrane protein-1 expression in AIDS-related lymphoma (1994)
    Oxford, UK : Blackwell Publishing Ltd
    Histopathology 25 (1994), S. 0 
    Details
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The expression of bcl-2 protein and Epstein–Barr virus (EBV) latent membrane protein 1 (LMP-1) was investigated in 18 cases of lymphoma occurring in the acquired immunodeficiency syndrome (AIDS). EBV small RNAs were detectable in tumour cells in all cases by in situ hybridization with EBER oligonucleotides. LMP-1 expression was detected in 61% of the cases, and 55% were positive for bcl-2. Dual expression of LMP-1 and bcl-2 was found in 8/18 (44%) cases, while five cases (28%) expressed either LMP-1 or bcl-2 and five expressed neither. Thus, there was an inconsistent relationship between the presence of EBV and the expression of bcl-2. One LMP-1 negative case was found to express bcl-2 in reactive lymphocytes but not in lymphoma cells. No clinical features were found to correlate statistically with LMP-1 or bcl-2 expression in the tumour cells. However, CD4 counts at diagnosis were significantly lower in bcl-2 positive cases (P 〈 0.05). The respective roles of EBV LMP-1 and the expression of bcl-2 in lymphogenesis in AIDS patients remains complex and is not yet fully understood.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2559.1994.tb00601.x
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  • 2
    Electronic Resource
    Electronic Resource
    High-dose therapy followed by stem cell transplantation in partial response after first-line induction therapy for aggressive non-Hodgkin's lymphoma (1998)
    Springer
    Annals of oncology 9 (1998), S. 5-8 
    Details
    ISSN: 1569-8041
    Keywords: aggressive non-Hodgkin's lymphoma ; autologous stem cell transplantation ; high-dose therapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Patients with aggressive non-Hodgkin's lymphoma who fail to achieve a complete remission (CR) with standard induction therapy have a poor prognosis with conventional-dose salvage therapy alone. Retrospective series have suggested that early introduction of high-dose salvage therapy with autologous stem cell transplantation (ASCT) may benefit partial-responder (PR) patients. However, two randomized studies (of 69 and 51 patients with partial clinical responses) failed to demonstrate any advantage of intensive therapy. By contrast, the GELA comparative study on 94 PR-patients (residual disease being histologically documented in 53 patients) suggested that high-dose therapy with ASCT improves survival. Interpretation of all these results is complicated by the heterogeneity of patient populations with respect to initial prognostic factors, induction regimens and, in particular, the criteria used to define partial response. Gallium CT scan and magnetic resonance imaging are now used to better explore residual masses. In the future, early restaging with these imaging techniques might be used to delineate patients who are likely to achieve CR from those who will fail to induction treatment and could be candidates for experimental treatments.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1008291723029
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  • 3
    Electronic Resource
    Electronic Resource
    Incidence and risk factors of central nervous system relapse in histologically aggressive non-Hodgkin's lymphoma uniformly treated and receiving intrathecal central nervous system prophylaxis: A GELA study on 974 patients (2000)
    Springer
    Annals of oncology 11 (2000), S. 685-690 
    Details
    ISSN: 1569-8041
    Keywords: aggressive non-Hodgkin's ; CNS relapse ; meningeal prophylaxis ; methotrexate ; risk factors
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background:Incidence of central nervous system (CNS) recurrencein patients with aggressive non-Hodgkin's lymphoma who did not receivemeningeal prophylaxis is about 5%. Controversy remains regarding riskfactors associated with such an event preventing a rational approach ofprophylactic strategies. Patients and methods:We analyzed a cohort of 974 patients withaggressive lymphoma in complete remission (CR). All the patients received aCNS prophylaxis consisting of intrathecal injections and intravenous high-dosemethotrexate. The risk repartition on the basis of the internationalprognostic index (IPI) of these 974 CR-patients was low (L): 41%,low-intermediate (LI): 27%, high-intermediate (HI): 19%, high(H): 13%. Results:The incidence of isolated CNS relapse was 1.6%.In a first multivariate logistic regression analysis an increased LDH (P= 0.05, RR = 5) and the presence of more than one extranodal site (P= 0.05, RR = 3) were identified as independent risk factors for isolatedCNS relapse. Another multivariate analysis incorporating IPI as a uniqueparameter showed that only IPI remained significantly associated with a higherrisk of CNS relapse (L–LI: 0.6% vs. HI–H: 4.1%,P= 0.002; RR = 7). Conclusion:Prophylaxis notably reduces the risk of CNS recurrencein the higher risk patients. By contrast, we propose the deletion ofprophylactic intrathecal injections in the lower risk patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1008394827806
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  • 4
    Electronic Resource
    Electronic Resource
    Association of the Philadelphia chromosome and 5q- in secondary blood disorder
    Amsterdam : Elsevier
    Cancer Genetics and Cytogenetics 30 (1988), S. 253-259 
    Details
    ISSN: 0165-4608
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0165-4608(88)90192-6
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  • 5
    Electronic Resource
    Electronic Resource
    Renal angiomyolipoma: comparison of MRI and CT results for diagnosis (1992)
    Springer
    European radiology 2 (1992), S. 465-472 
    Details
    ISSN: 1432-1084
    Keywords: Kidney, CT ; Kidney, haemorrhage ; Kidney, MR studies ; Kidney, neoplasms
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The aim of this study was to compare the potentials of MRI and CT for characterising renal angiomyolipomas. MRI and CT examinations of 13 adult patients with renal angiomyolipoma were reviewed. Pathological correlation was available for ten patients who underwent nephrectomy or tumourectomy. Negative CT density numbers were demonstrated in 10 cases. MRI depicted high signal intensity areas suggesting fat in 11 cases. A haemorrhagic component was by both CT and MRI in 4 cases and was confirmed by surgery. Fat suppression imaging was performed in 3 cases and confirmed the presence of fat. We conclude that identification of angiomyolipomas can be achieved by MRI, but compared with CT, MRI is more expensive and less available. Therefore MRI should be performed when CT results are equivocal and when direct multiplanar images are necessary for a precise tumour localisation of multiple angiomyolipomas.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00176355
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  • 6
    Electronic Resource
    Electronic Resource
    Bone remodelling in monoclonal gammopathies of uncertain significance, symptomatic and nonsymptomatic myeloma (1996)
    Springer
    Clinical rheumatology 15 (1996), S. 347-352 
    Details
    ISSN: 1434-9949
    Keywords: Myeloma ; Histomorphometry ; Calciuria/Creatinine Ratio ; Osteocalcin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In order to characterize the abnormalities of bone remodelling in the various stages of plasma cell disorders, we studied 60 patients (29 monoclonal gammopathies of uncertain significance (MGUS), 13 stage I myeloma, 18 stage III myeloma). We carried out histomorphometric study of bone biopsies in 34 patients and measurement of osteocalcin and the calciuria/creatinine ratio. Bone remodelling was approximately normal (BV/TV: 21.2±7, ES: 4.1±2, OS: 16.5±10) in MGUS. Stage I myeloma was characterised by parallel increases in resorption surfaces and osteoid surfaces (BV/TV: 18±5, ES/BS: 7.4±3.5, OS/BS: 24.8±11.5), of the ca/cr ratio and osteocalcin. In stage III myeloma, resorption surfaces and the ca/cr ratio showed an even greater increase while osteoid surfaces, osteocalcin and trabecular bone volume decreased (BV/TV 13.6±6, ES/BS: 12.1±6, OS/BS: 13.6±8.3). Osteocalcin and osteoid surfaces were correlated (r=0.5). There was a positive correlation between osteocalcin and the number of plasmocytes in stage 1 myeloma (r=0.64) and a negative correlation in stage III myeloma (r=0.9). Bone remodeling was normal in MGUS; bone remodelling grew with a parallel increase of formation and resorption in stage I; bone resorption increased while bone formation decreased in stage III myeloma.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02230356
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