Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    DISTRIBUTION OF CHOLINE ACETYLTRANSFERASE AND GLUTAMATE DECARBOXYLASE WITHIN THE SUBSTANTIA NIGRA AND IN OTHER BRAIN REGIONS FROM CONTROL AND PARKINSONIAN PATIENTS (1975)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 25 (1975), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: —The distribution of choline acetyltransferase (ChAc, EC 2.3.1.6) and l-glutamate 1-carboxylyase (glutamate decarboxylase, GAD, EC 4.1.1.15) was studied in serial frontal slices of the substantia nigra (SN) (pars compacta, PC; pars reticulata, PR; an intermediate region, IR) as well as in other brain areas from post mortem tissue of control and Parkinsonian patients.Within the SN from control brain ChAc and GAD activities showed a distinctive distribution: ChAc activity in PC was higher than in PR and IR by 427% and 253% respectively and within PC the enzyme activity in the rostral part exceeded that in the control part by 353%. The GAD activity in PC was higher by 41% than that in PR and within PC seemed to be higher in the caudal than in the rostral part. For both enzyme activities there were no significant differences between PR and IR or within these regions.In Parkinsonian brain both ChAc and GAD activities were reduced to 15-25% of controls in all 3 regions of the SN. The distinctive distribution of ChAc and GAD activity found in the SN of control brain was abolished: no difference was observed between the 3 regions. However, within PC the ChAc activity was lower in the medial than in the rostral part.Since nigral ChAc is possibly located in interneurons, the decrease in enzyme activity may be connected with the cell loss observed in the SN of Parkinsonian brain.By contrast, nigral GAD is probably contained in terminals of strio-nigral neurons and the decrease in enzyme activity in Parkinson's disease in the absence of striatal cell loss, may reflect a change in the functional state of these GABA neurons.Among various areas of control brains ChAc activity was highest in caudate nucleus and putamen while GAD was highest in SN. caudate nucleus, putamen and cerebral cortex. In Parkinsonian brain the most severe reduction in ChAc and GAD activities was found in the SN.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1975.tb04409.x
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Formation of noradrenaline in the rat brain from the four stereoisomers of 3,4-dihydroxyphenylserine (1974)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 281 (1974), S. 443-446 
    Details
    ISSN: 1432-1912
    Keywords: DOPS ; Stereoisomers ; Decarboxylation ; Brain NA
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Intraperitoneal injection of the (+)-erythro isomer of 3,4-dihydroxyphenylserine (DOPS) to rats markedly increased the concentration of cerebral noradrenaline (NA) which probably corresponds to the unnatural (+) form. In contrast, the other 3 stereoisomers of DOPS caused only a minor rise of NA. This difference is likely to be connected with the configuration of the stereoisomers at the α and β carbon which determines the rate of decarboxylation and possibly of penetration into the brain.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00499439
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Dopaminergic inhibition of striatal cholinergic neurons: Synergistic blocking action of γ-butyrolactone and neuroleptic drugs (1974)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 283 (1974), S. 129-134 
    Details
    ISSN: 1432-1912
    Keywords: Neuroleptic Drugs ; γ-Butyrolactone ; Dopaminergic Transmission ; Striatal ACh
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effect of drugs administered i.v. on the release of acetylcholine (ACh) within the caudate nucleus perfused by means of push-pull cannulae was studied in the gallamine-immobilized cat. The antipsychotic compound clozapine (a dopamine receptor blocking agent) in a dose of 50 mg/kg markedly increased the ACh output; 20 mg/kg of the drug were ineffective. Combination of γ-butyrolactone with 20 mg/kg clozapine caused an increase of ACh output similar to that observed after 50 mg/kg clozapine. Similar results were obtained with chlorpromazine. This and other evidences suggest that cholinergic neurons in the striatum are under an inhibitory dopaminergic influence. The lack of effect on ACh output of relatively low doses of neuroleptics (e.g. 20 mg/kg clozapine) is probably explained by a partial dopamine receptor blockade which is surmounted by the feedback activation of dopaminergic neurons. Impairment of this activation by γ-butyrolactone is likely to result in a further diminution of dopamine at the receptors, leading to a disinhibition of cholinergic neurons.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00501139
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    “In vivo” release of endogenous neurotransmitters in cat limbic regions: Effect of chlorpromazine and of electrical stimulation (1975)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 288 (1975), S. 1-6 
    Details
    ISSN: 1432-1912
    Keywords: Chlorpromazine ; Septal Stimulation ; Limbic Neurotransmitters
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effect of chlorpromazine (10 mg/kg i.v.) on the spontaneous release of endogenous dopamine (DA), noradrenaline (NA) and acetylcholine (ACh) within limbic areas perfused by means of the push-pull cannula was investigated in the gallamine-immobilized cat. Chlorpromazine increased the liberation of DA and NA in the nucleus accumbens septi, indicating blockade of the amine receptors. However, the drug did not change the output of ACh from this nucleus nor from ventral and dorsal hippocampal formation which receive a cholinergic input from the septum as indicated by several published findings and by the increased liberation of ACh after electrical stimulation of the homolateral nucleus medialis septi. These results seem to exclude that cholinergic neurons of some limbic areas mediate the effect of the blockade of DA (and of NA) receptors which is possibly involved in the antipsychotic action of neuroleptic drugs.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00501809
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 5
    Electronic Resource
    Electronic Resource
    Demethylation of l-3-methoxytyrosine in vivo (1972)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 274 (1972), S. 404-409 
    Details
    ISSN: 1432-1912
    Keywords: l-3-Methoxytyrosine ; Demethylation ; l-DOPA ; Dopamine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary After administration of purified l-14C-3-methoxytyrosine (l-14C-3-MTO) to rats, the fractions of labelled amino acids, catecholamines and phenolcarboxylic acids of urine and brain have been separated by column chromatography. Prior to performing the quantitative determinations, the individual metabolites of each urinary fraction and of the cerebral catecholamine fraction were isolated by paper chromatography using different systems. Susbtantial amounts of 14C-3,4-dihydroxyphenylacetic acid (14C-DOPAC) as well as some 14C-3,4-dihydroxyphenylalanine (14C-DOPA) and traces of dopamine (DA) appeared in the urine. Furthermore, small amounts of 14C-DA and 14C-norepinephrine were found in the brain with two different chromatographic systems. The urinary excretion of 14C-DOPAC and 14C-DA was increased by pretreatment with dopacetamide, an inhibitor of catechol-3-O-methyl-transferase. A possible contamination of the l-14C-3-MTO with traces of l-14C-DOPA as a major source of the dihydroxylated metabolites has been ruled out. It is concluded that part of l-3-MTO undergoes demethylation in vivo and that the finding of DA in brain and urine after administration of l-3-MTO is not an artifact.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00501277
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 6
    Electronic Resource
    Electronic Resource
    Enhancement of cerebral noradrenaline turnover by thyrotropin-releasing hormone (1974)
    [s.l.] : Nature Publishing Group
    Nature 248 (1974), S. 528-529 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Male albino rats of 200 g, Wistar origin, were injected intraperitoneally with TRH. Thereafter noradrenaline, dop-amine, 5-hydroxytryptamine (5-HT) as well as their corresponding main metabolites 3-methoxy-4-hydroxyphenyl-ethyleneglycol (MOPEG, isolated as the sulphate ester), homovanillic acid and ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/248528a0
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 7
    Electronic Resource
    Electronic Resource
    Acetylcholine Release within the Cat Striatum during the Sleep–Wakefulness Cycle (1973)
    [s.l.] : Nature Publishing Group
    Nature 243 (1973), S. 518-519 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] In five cats of either sex (2.5?3.0 kg), the following electrodes were implanted under pentobarbital anaesthesia (35 mg kg?1 intraperitoneally) : (1) Bipolar electrodes (0.4 mm diameter) in one lateral geniculate body (coordinates: L = 10, A =6, H= +2.5 (ref.6)); (2) bilateral cortical (occipital) ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/243518a0
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 8
    Electronic Resource
    Electronic Resource
    3-O-Methyldopa, a New Precursor of Dopamine (1971)
    [s.l.] : Nature Publishing Group
    Nature 230 (1971), S. 533-534 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] We have identified and measured other minor metabolites of L-3-O-methyldopa in the urine, and investigated the effect of enzyme inhibitors on the metabolism of this amino-acid in the brain. We wish to report evidence that L-3-O-methyldopa is partially demethylated in the organism. Rats of both ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/230533a0
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 9
    Electronic Resource
    Electronic Resource
    In vivo enhancement of tyrosine hydroxylation in rat striatum by tetrahydrobiopterin (1974)
    [s.l.] : Nature Publishing Group
    Nature 249 (1974), S. 476-478 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Male albino rats of Wistar origin (Fullinsdorf), 180-200 g, were injected with an aqueous solution of BH4 into one lateral brain ventricle (30-1,000 Mg in 10 /4 through a chronically implanted cannula10) or intravenously (125 mg kg-1)- The solutions contained 1 % ascorbic acid. o At various time ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/249476a0
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 10
    Electronic Resource
    Electronic Resource
    Atropine-induced changes of cerebral dopamine turnover (1971)
    Springer
    Cellular and molecular life sciences 27 (1971), S. 1302-1303 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Zusammenfassung Nach Applikation von Atropin in die Hirnventrikel von Ratten kommt es zu einer starken Erhöhung der Homovanillinsäure (HVA) im Gehirn, während dessen Gehalt an Dopamin nicht vermindert wird. Intraperitoneale Injektion von Atropin bewirkt dagegen eine Abnahme von HVA, ebenfalls ohne Beeinflussung des Dopamins im Gehirn. Es wird vermutet, dass zwei regulatorische cholinergische Mechanismen bestehen, die eine entgegengesetzte Wirkung auf den Dopaminumsatz der basalen Ganglien haben.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02136701
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...