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  • 1
    Electronic Resource
    Electronic Resource
    Oral pharmacokinetics of cyclosporin in patients with primary biliary Cirrhosis and patients with skin diseases (1992)
    Oxford, UK : Blackwell Publishing Ltd
    Alimentary pharmacology & therapeutics 6 (1992), S. 0 
    Details
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The pharmacokinetics of cyclosporin after oral administration were studied in seven patients with non-end stage primary biliary cirrhosis (PBC) without previous cyclosporin treatment (Group I), a control group of nine patients with skin diseases (mainly psoriasis; Group II) and six patients with PBC after prolonged cyclosporin treatment (Group III). Whole blood concentrations of cyclosporin were measured using a nonspecific (N) radioimmunoassay (RIA) and — in a majority of the cases—also by a RIA specific (S) for the parent drug. No difference in cyclosporin absorption was observed between patients with PBC and those with a skin disease. The mean values for the area under the blood concentration-time curve for the first 6 h after the test dose (AUC0-6) and the maximal blood concentrations (Cmax) were significantly higher for Group I compared with Group II patients (P= 0.007 and 0.03, respectively), but the time to maximal blood concentrations (tc, max) did not differ. There was a trend toward higher mean AUC0-6 (P= 0.08) and Cmax (P= 0.08) values for Group III compared with Group I patients. Tc, max values were not influenced by prolonged cyclosporin treatment. The ratio of cyclosporin whole blood concentrations measured by the non-specific and specific RIA'S (N/S ratio) increased with time without obvious differences between the three groups. These data suggest that cyclosporin absorption and its biotransformation in the liver are not impaired in patients with non-end stage PBC and that neither is affected by prolonged treatment.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2036.1992.tb00559.x
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  • 2
    Electronic Resource
    Electronic Resource
    Short-term use of cyclosporin A in severe psoriasis (1986)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 114 (1986), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The effectiveness of cyclosporin A (CyA) in low dosages (mean 5 mg/kg/day) for short-term treatment of severe psoriasis was studied. Of five patients with severe progressive psoriasis vulgaris (mean PASI score 43.8), an almost complete remission in three patients, and a large reduction in PASI score in the remaining two patients, was obtained within 4 weeks. No important clinical side-effects were found but there was biochemical evidence of slight renal dysfunction in one patient. The mean percentage reduction in the PASI score was 84%. It was concluded that the results reported justify further study of the use of CyA in the treatment of severe psoriasis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1986.tb04070.x
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  • 3
    Electronic Resource
    Electronic Resource
    Isolation and identification of the irradiation product of thymine
    Amsterdam : Elsevier
    BBA - Biochimica et Biophysica Acta 41 (1960), S. 550-551 
    Details
    ISSN: 0006-3002
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Medicine , Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0006-3002(60)90063-9
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  • 4
    Electronic Resource
    Electronic Resource
    The effects of u.v.-irradiation on nucleic acids and their components
    Amsterdam : Elsevier
    BBA - Biochimica et Biophysica Acta 49 (1961), S. 181-189 
    Details
    ISSN: 0006-3002
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Medicine , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0006-3002(61)90881-2
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  • 5
    Electronic Resource
    Electronic Resource
    The effect of paramagnetic substances on the conversion of some pyrimidines by ultraviolet radiation
    Amsterdam : Elsevier
    BBA - Biochimica et Biophysica Acta 38 (1960), S. 573-575 
    Details
    ISSN: 0006-3002
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Medicine , Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0006-3002(60)91302-0
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  • 6
    Electronic Resource
    Electronic Resource
    MYC 8005, an antibiotic against spider mites. 1. Description of the producing organism (Streptomyces exfoliatus var. echnosporus var. nov.) and properties of the antibiotic (1972)
    Springer
    European journal of plant pathology 78 (1972), S. 1-14 
    Details
    ISSN: 1573-8469
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Abstract An antibiotic substance, MYC 8005, was found to be produced by aStreptomyces strain, D197. It proved to possess strong antibiotic activities against bacteria, fungi and spider mites. It might be similar to antibiotic 323/58 reported in 1962 by Kruglyaket al. This antibiotic, however, is no longer available for comparison. The producing organism resmblesStreptomyces exfoliatus (Waksman & Curtis) Waksman & Henrici but differs from this species in the surface structure of the spores. For this reason it is proposed to give D 197 the nameStreptomyces exfoliatus var.echinosporus var. nov. The nature of the symptoms observed with spider mites and the susceptibility of various acaricide-resistant strains to this antibiotic suggest a new mode of action.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01976377
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  • 7
    Electronic Resource
    Electronic Resource
    Graphite melting under laser pulse heating (1992)
    Springer
    International journal of thermophysics 13 (1992), S. 107-129 
    Details
    ISSN: 1572-9567
    Keywords: graphite ; high-speed measurements ; high temperatures ; laser heating ; melting ; triple point
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract For a long time, the solid/liquid/vapor triple point of graphite has been a subject of debate, and despite the progress in the experimental techniques adopted, the uncertainties became even greater in recent years. In the experiments described in this paper spherical graphite specimens were heated by four tetrahedrally oriented laser beams to produce a fairly uniform temperature on the surface. A sufficiently large amount of molten graphite was produced to make it possible to identify the liquid/solid transition by a conventional thermoanalytical method. The temperature was measured by multichannel pyrometry, which enabled a detailed analysis of the perturbations and errors to be carried out. The triple point of graphite was determined to be T t=4100±50 K and p t=110±10 bar.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00503360
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