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  • 1
    Electronic Resource
    Electronic Resource
    Attenuation of allergic airway inflammation in IL-4 deficient mice (1994)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical & experimental allergy 24 (1994), S. 0 
    Details
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: To investigate the role of IL-4 in vivo in allergic asthma, we developed a murine model of allergen-induced airway inflammation. Repealed daily exposures of actively immunised C57BL/6 mice to aerosolized ovalbumin (OVA) induced a peribronchial inflammation and an increase in eosinophils and lymphocytes in bronchoalveolar-lavage(BAL) fluid. In IL-4 deficient (IL4−/−) mice, treated in the same way, there were substantially fewer eosinophils in BAL and much less peribronchial inflammation compared with wild type mice. In this model, mast cell deficient (W/Wv) mice developed a similar degree of BAL eosinophilia and peribronchial inflammation as wild type mice, demonstrating that the mast cell is not required for the induction of chronic airway inflammation. In contrast, BAL eosinophilia and airway inflammation were absent in OVA-treated MHC ClassII deficient (B6.Aa−/−) mice which lack mature CD4+ T lymphocytes. In conclusion, these results indicate that IL-4 is a central mediator of allergic airway inflammation, regulating antigen-induced eosinophil recruitment into the airways by a T cell dependent mechanism.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2222.1994.tb00920.x
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  • 2
    Electronic Resource
    Electronic Resource
    Analysis of the immune system with transgenic mice: T cell development (1991)
    Springer
    Cellular and molecular life sciences 47 (1991), S. 884-890 
    Details
    ISSN: 1420-9071
    Keywords: Transgenic mice ; immune system ; T cell development ; T cell receptor ; scid mutation ; lpr mutation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Transgenic mice carrying functionally rearranged T cell receptor genes have contributed significantly to our knowledge of T cell development and thymic positive and negative selection processes. In addition, TCR-transgenic mice have been used to investigate mutations affecting thymocyte development, likescid andlpr. Gene targeting by homologous recombination will allow to analyze more specifically the molecular mechanisms underlying thymic selection and peripheral tolerance.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01929878
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    DNA-binding properties of a nonhistone chromosomal protein from lymphocytes (1978)
    Springer
    Molecular and cellular biochemistry 19 (1978), S. 147-153 
    Details
    ISSN: 1573-4919
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Summary The DNA binding properties of the nonhistone chromosomal protein NH 30 000 from lymphocytes were investigated by equilibrium competition experiments employing nitrocellulose filters. The results show that protein NH 30 000 interacts preferentially with single-stranded DNA, with AT-rich sequences and with repetitive DNA. Binding to RNA, however, is poor, with different RNAs exhibiting different competitive abilities.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00225452
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Affinity chromatography of nonhistone chromosomal proteins from lymphocytes on DNA-agarose columns (1978)
    Springer
    Molecular biology reports 4 (1978), S. 33-37 
    Details
    ISSN: 1573-4978
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract A two step procedure is presented consisting of hydroxyapatite and DNA-agarose chromatography which allows the isolation of nonhistone chromosomal proteins with different affinities towards single stranded DNA. The application of this fractionation scheme to nonhistone chromosomal proteins from bovine lymphocytes is described.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00775178
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    Paper (German National Licenses)
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