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The Multifactorial and Multistage Character of Protective Immunity to Plasmodium falciparum, Naturally Acquired by an Indigenous Population in Burkina Faso (1994)

BOUDIN, C. ; SHEICK, I. ; CHUMPITAZI, B. ; [et al.]

Oxford, UK : Blackwell Publishing Ltd

Scandinavian journal of immunology 39 (1994), S. 0

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ISSN: 1365-3083

Source: Blackwell Publishing Journal Backfiles 1879-2005

Topics: Medicine

Notes: In malaria-endemic areas, protective immunity is acquired gradually. Some authors have proposed that different stages can be distinguished during development. To test this hypothesis, several in vitro assays of the host immune response to P. falciparum were performed in three groups of individuals: ‘unprotected’ children with clinical attacks, ‘semi-immune’ children, without clinical attacks but with transient high parasitaemias during the transmission period, and ‘protected’ adults with low residual parasitaemias. By comparison of immune responses in these groups and multifactorial analyses, discriminant factors and potential protective mechanisms were identified. Anti-RESA antibody levels were lower in ‘unprotected’ than in ‘semi-immune’ children, while specific cellular responses, TNF levels and percentage of activated T lymphocytes were higher. Low humoral immunity and high cellular activation in children were followed by high humoral immunity and low cellular activation in adults. Therefore, protective immunity seems to pass through different stages and to result from the association of different immune mechanisms according to the level and duration of the individual experience of malaria.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1111/j.1365-3083.1994.tb03393.x

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Circulating stable antigens at higher levels down-regulate antibody responses toPlasmodium falciparum (1993)

Chumpitazi, B. ; Lepers, J -P. ; Rason, M. ; [et al.]

Springer

Parasitology research 79 (1993), S. 163-167

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ISSN: 1432-1955

Source: Springer Online Journal Archives 1860-2000

Topics: Biology , Medicine

Notes: Abstract A study involving 169 schoolchildren (5–14 years old) living in Manarintsoa near Antananarivo (Madagascar, East Africa) was performed during the seasonal malaria transmission period. For the whole population examined, the prevalence ofPlasmodium falciparum and the rates of spleen enlargement and of circulating stable antigen (S-Ag) were found to be 60.9%, 71.7%, and 46,8%, respectively. The prevalence of IgG antibody to RESA (ring-infected erythrocyte surface antigen) was 42.7% and that of IgG and IgM antibodies to E-Ag (exoantigens) was 44.9% and 2.9%, respectively. The positive rates for IgG and IgM antibodies to Som-Ag (somatic antigen) were 48.5% and 5.9%, respectively. Concerning S−Ag, no significant relationship was observed for parasitemia, spleen size, age, or IgM antibody responses to exoantigens (E-Ag) or to somatic antigen (Som-Ag). Levels of S−Ag were found to be related to IgG antibodies to E-Ag. Our results suggest that S−Ag at low levels may participate in the mechanisms involved in the development of the IgG antibody responses to E-Ag and to Som-Ag, whereas at a comparative population level, higher quantities of S−Ag down-regulate antibody responses toP. falciparum. The data we obtained were compared with those gathered in another malaria mesoendemic area (Bobo-Dioulasso, Burkina Faso, West Africa), where lower levels of S−Ag were found.