ISSN:
1573-904X
Keywords:
microspheres
;
indomethacin
;
cumulative release profile
;
release, single microsphere
;
controlled release, first-order kinetics
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract Indomethacin microspheres based on a combination of ethylcellulose and polyethyleneglycol were prepared using the solvent evaporation process. Release profiles of ensemble and individual microspheres were measured. Both were found to follow first-order kinetics, in contrast to what was expected. This was attributed to the fact that all the particles showed the same kinetic pattern and had a greater degree of homogeneity in the payload, mean particle size and shape, and k l values than in ensembles of microcapsules.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1023/A:1015917023949
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