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  • 1
    Electronic Resource
    Electronic Resource
    Effects of estradiol on worm burden and peripheral leukocytes inParastrongylus malaysiensis-infected rats (1994)
    Springer
    Parasitology research 80 (1994), S. 74-77 
    Details
    ISSN: 1432-1955
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Gonadectomized male laboratory rats were given 0.06 mg/kg estradiol benzoate daily for 14 days before being inoculated with 50 third-stage larvae ofParastrongylus malaysiensis. Hormone treatment was continued until the rats were killed. The numbers of larvae in the brain and of adult worms in the pulmonary area of the rats were determined every 7 days after the inoculation. It was found that the rats treated daily with estradiol benzoate had significantly and consistently higher numbers of larvae and adult worms as compared with the controls. The number of total leukocytes increased significantly after the rats were infected. The results show that estradiol-treated rats become susceptible toP. malaysiensis infection, which may indicate that the immunosuppressive effects of testosterone observed in earlier studies may partly be caused by estradiol that was peripherally aromatized from testosterone.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00932628
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Worm burden and leukocyte response inAngiostrongylus malaysiensis-infected rats: the influence of testosterone (1992)
    Springer
    Parasitology research 78 (1992), S. 388-391 
    Details
    ISSN: 1432-1955
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Gonadectomized male albino rats aged 7 weeks were given 1.5 mg/kg testosterone propionate daily and inoculated with 50 third-stage larvae ofAngiostrongylus malaysiensis. The treatment significantly increased the number of larvae and adult worms recovered from the brain and pulmonary arteries, respectively, and the rats exhibited smaller thymus glands. The total numbers of leukocytes, monocytes, neutrophils, and especially eosinophils increased significantly post-infection, but the counts were higher in the untreated infected controls. Presumably, immunosuppressive effects of testosterone may at least partly be responsible for the higher loads ofA. malaysiensis worms found in male rats as compared with females in the field.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00931693
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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