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  • 1
    Electronic Resource
    Electronic Resource
    18S rRNA sequences and phylogeny of platyhelminthes
    Amsterdam : Elsevier
    Biochemical Systematics and Ecology 21 (1993), S. 71-77 
    Details
    ISSN: 0305-1978
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0305-1978(93)90010-O
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  • 2
    Electronic Resource
    Electronic Resource
    On the search and immunolocalization of proliferative substances in planarians
    Amsterdam : Elsevier
    Cell Biology International Reports 14 (1990), S. 92 
    Details
    ISSN: 0309-1651
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0309-1651(90)90469-F
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  • 3
    Electronic Resource
    Electronic Resource
    Planarian neoblasts (1981)
    [s.l.] : Nature Publishing Group
    Nature 290 (1981), S. 14-15 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] IN a News and Views article on 21 August 1980 Jonathan Slack1 reviewed briefly the sources of the cells involved in regeneration in planaria and, in doing so, made several assertions that deserve comment. (1) 'Neoblasts' are indeed small basophilic cells present in planaria. But to think of them ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/290014b0
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  • 4
    Electronic Resource
    Electronic Resource
    Chromosomal polymorphism in planarians (Turbellaria, Tricladida) and the plate tectonics of the western Mediterranean (1984)
    Springer
    Genetica 62 (1984), S. 187-191 
    Details
    ISSN: 1573-6857
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract In two populations of Dugesia (Schmidtea) mediterranea the third chromosome pair consists of two heteromorphous elements. This chromosomal polymorphism, which is common in other animal groups, was hitherto unknown in planarians. The evolutionary and biogeographical significance of this chromosomal polymorphism is discussed, for the geographical distribution of the two aberrant populations may have relevance for the theories of microplate dispersal involving the western Mediterrancan.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00056435
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  • 5
    Electronic Resource
    Electronic Resource
    patufet, the gene encoding the Drosophila melanogaster homologue of selenophosphate synthetase, is involved in imaginal disc morphogenesis (1998)
    Springer
    Molecular genetics and genomics 257 (1998), S. 113-123 
    Details
    ISSN: 1617-4623
    Keywords: Key words Selenophosphate synthetase ; patufet ; Morphogenesis ; Imaginal discs ; Apoptosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Proliferation in imaginal discs requires cell growth and is linked to patterning processes controlled by secreted cell-signalling molecules. To identify new genes involved in the control of cell proliferation we have screened a collection of P-lacW insertion mutants that result in lethality in the larval/pupal stages, and characterized a novel gene, patufet (ptuf). Inactivation of ptuf by a P element insertion in the 5′ untranslated region leads to aberrant imaginal disc morphology characterized by a reduction in mass of discs and disorganisation of disc cells where no folding or patterning can be detected. Moreover, apoptotic cells can be observed in these small and abnormal mutant discs. To examine the role of ptuf we have studied its clonal behaviour in genetic mosaics generated by mitotic recombination. The mutation causes reduced cell viability, smaller cell size and stops vein differentiation. Non-autonomous effects, such as abnormal differentiation of wild-type cells surrounding the clones, are also observed. We have cloned the ptuf gene of Drosophila melanogaster and found that it encodes a selenophosphate synthetase, which is the first identified in insects. Mutant flies transformed with the full-length cDNA show complete reversion of lethality and disc phenotype. Northern blot analysis and in situ hybridization indicate that the ptuf gene is expressed in imaginal discs as well as at different stages of development. The synthesis of selenoproteins by the selenophosphate synthetase, the role of selenoproteins in the maintenance of the oxidant/antioxidant balance of the cell and its possible implications in imaginal disc morphogenesis are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004380050630
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  • 6
    Electronic Resource
    Electronic Resource
    Synchronous and early activation of planarian Hox genes and the re-specification of body axes during regeneration in Dugesia (G.) tigrina (Turbellaria; Tricladida) (1998)
    Springer
    Hydrobiologia 383 (1998), S. 125-130 
    Details
    ISSN: 1573-5117
    Keywords: Planarian ; Hox ; gene expression
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Seven Hox cluster-related genes (Dthox-A to -G) have been isolated from the freshwater triclad Dugesia (G.) tigrina, their sequence compared to other Hox genes and their expression in intact and regenerating organisms analyzed by whole mount in situ hybridization. Sequence comparison analyses show high similarities of D. tigrina Hox genes to anterior and medial groups of coelomate Hox genes. Expression analyses show very early, synchronous, and overlapping expression of Dthox -A, -E, -G and -F in anterior, posterior and lateral regenerative tissues. At one hour of regeneration all Dthox genes studied showed a neat, clear expression at the wound boundary. Later, as the blastema grows, the expression area expands to more proximal regions covering the blastema and the distal postblastema regions. Blastemas formed by intercalary regeneration also show a synchronous expression of the same Hox genes though the onset of activation is much delayed. The finding that the same set of Hox genes is synchronously activated in anterior, posterior, intercalary and lateral regeneration is in sharp contrast to its well established role in specifying antero-posterior pattern during embryonic development. The implications of these results as regards ancestral versus co-opted roles of Hox genes in development and regeneration are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1003427408356
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  • 7
    Electronic Resource
    Electronic Resource
    Quantitative analysis of cell types during growth, degrowth and regeneration in the planarians Dugesia mediterranea and Dugesia tigrina (1981)
    Springer
    Hydrobiologia 84 (1981), S. 181-194 
    Details
    ISSN: 1573-5117
    Keywords: Turbellaria ; Dugesia ; cell types ; growth ; degrowth ; regneration ; maceration-technique
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract A method of tissue maceration (dissociation) of planarian tissues into single cells was used to characterize the basic cell types in the planarians Dugesia mediterranea and Dugesia tigrina, and to determine the total cell number and distribution of cell types during growth, degrowth and regeneration. Using this method, 13 basic cell types have been determined for both species. The total number of cells increases with body length and volume whereas the distribution of cell types is only slightly affected. Growth and degrowth occur mainly through changes in total cell number leaving cell distribution only moderately affected. During regeneration, an increase in neoblast density in the blastema followed later on by increases in nerve cells are the more significant changes detected. These results are discussed in relation to mechanisms of cell renewal, blastema formation and maintenance of tissue polarity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00026179
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  • 8
    Electronic Resource
    Electronic Resource
    Screening of larval/pupal P-element induced lethals on the second chromosome in Drosophila melanogaster: clonal analysis and morphology of imaginal discs (1998)
    Springer
    Molecular genetics and genomics 257 (1998), S. 103-112 
    Details
    ISSN: 1617-4623
    Keywords: Key words Clonal analysis ; Imaginal discs ; Cell proliferation ; P elements
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract We have carried out screens for lethal mutations on the second chromosome of Drosophila melanogaster that are associated with abnormal imaginal disc morphologies, particularly in the wing disc. From a collection of 164 P element-induced mutations with a late larva/pupa lethal phase we have identified 56 new loci whose gene products are required for normal wing disc development and for normal morphology of other larval organs. Genetic mosaics of these 56 mutant lines show clonal mutant phenotypes for 23 cell-viable mutations. These phenotypes result from altered cell parameters. Causal relationships between disc and clonal phenotypes are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/PL00008620
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