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  • 1
    Electronic Resource
    Electronic Resource
    The ‘transitional’ mucosa adjacent to large bowel carcinoma—electron microscopic features and myofibroblast reaction (1982)
    Oxford, UK : Blackwell Publishing Ltd
    Histopathology 6 (1982), S. 0 
    Details
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: An electron microscopic study of the ‘transitional’ mucosa adjacent to 10 carcinomas of the colon showed impaired maturation of epithelial cells. The pericryptal fibroblast layer was absent, accounting for an increase in the length and distension of crypts. In the tunica propria a massive accumulation of myofibroblasts was noted and was indicative of an intensive fibre-producing activity. Review of the literature identifies various theories concerning the functions of myofibroblasts in respect of contraction, embryonal collagen-fibre formation and non-specific stromal reaction. Of these, the latter two are considered likely in relationship to transitional colonic mucosa.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2559.1982.tb02755.x
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  • 2
    Electronic Resource
    Electronic Resource
    Cholangiodysplastic pseudocirrhosis (1975)
    Springer
    Virchows Archiv 368 (1975), S. 61-71 
    Details
    ISSN: 1432-2307
    Keywords: Bile Canaliculus ; Bile Ductule ; Intercalary Cell ; Collagen Fibril ; Basal Membrane
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The familial type of cholangiodysplastic pseudocirrhosis is presented. This chronic liver disease is caused by malformation of the intrahepatic bile ducts. The female infant was 5 months old when the diagnosis was established. The liver biopsy was studied by light and electron microscopy. Electron microscopic examination revealed active proliferation of ductular cells and progression of fibrogenesis, findings consistent with the rapid and fatal course of the disease. In the case presented an acute cholangitis occurred, but after healing the progression of the original process led to hepatic insufficiency. It is suggested that cholangiodysplastic pseudocirrhosis is a chronic, progressive liver disease the course of which might be hastened by the complication of cholangitis; the process itself causes liver cirrhosis without inflammation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00432167
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Fine structure of multiple neonatal haemangioendothelioma of the liver (1978)
    Springer
    Virchows Archiv 379 (1978), S. 157-168 
    Details
    ISSN: 1432-2307
    Keywords: Endothelial cells ; Pericytes ; Basement membrane ; Reticular fibres
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary This paper discusses the fine structure of multiple haemangioendothelioma of the liver. There have been no previous reports of electron microscopic studies of this tumour, which was found to be composed of young capillaries continuous in type and varying in calibre. The capillaries were lined by actively proliferating, immature endothelial cells with pericytes forming an integral part of the tumour. Their morphological characteristics indicated intensive protein production. The authors suggest that the active pericytes play a role in the production of reticular fibres of the tumour. Following corticosteroid therapy, regression of tumour nodules occurred in this case in the interval between surgery and autopsy. This was confirmed by histological studies. The results seem to support the hypothesis that actively proliferating, young endothelial cells show an increased sensitivity to corticosteroids.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00432485
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Electron-microscopic study of the villous adenoma of the colon (1980)
    Springer
    Virchows Archiv 387 (1980), S. 193-205 
    Details
    ISSN: 1432-2307
    Keywords: Villous adenoma ; Absorptive cell ; Goblet cell ; Leuchtenberger's inclusion body
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The author studied the electron-microscopic peculiarities of villous adenoma as illustrated by 12 cases. She found that the dominant cells of villous adenoma are undifferentiated epithelial cells. Electron-microscopic signs of malignant transformation were revealed by nuclear changes, by the changes in the cytoplasmic membrane and by the immaturity of cells. Leuchtenberger's inclusion bodies are assumed to develop by herniation of cytoplasmic processes of immature tumour cells. In one tumour associated with electrolyte loss, atypical cells were observed with an electronmicroscopic picture indicative of an intense secretory activity. However, the secretion drops differed from the normal mucus drops of the mature goblet cells of the colonic mucosa. The author believes it to be possible that the tumour cells of atypical morphological appearance secrete mucus of abnormal composition which could be responsible for the syndrome of electrolyte loss.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00430700
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Comparative electron-microscopic studies of benign hepatoma and icterus in patients on oral contraceptives (1978)
    Springer
    Virchows Archiv 381 (1978), S. 97-109 
    Details
    ISSN: 1432-2307
    Keywords: Bile canaliculi ; Cell membrane ; Endothelial cell ; Disse's space ; Continuous capillary
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The author compared the electron-microscopic picture of 6 benign hepatomas and 3 specimens of icteric liver tissue in female patients on oral contraceptives. The majority of ultrastructural changes seen were identical in the tumor and non-tumor cases. It is noteworthy that there is an accumulation of filamentous substance of unknown origin in the bile canaliculi and in the Disse's spaces associated with a damage to the cell membrane. The electron-microscopic picture of the sinusoidal endothelial cells suggested an increased protein producing activity. The most conspicuous feature of the tumours was formation of continuous capillaries at the site of the sinusoids. The importance of systematic electron-microscopic investigation in studying the effect of oral contraceptives on the liver cells is stressed by the author.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00433489
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Electron-microscopic examination of primary diffuse tracheobronchial amyloidosis (1983)
    Springer
    Virchows Archiv 400 (1983), S. 97-106 
    Details
    ISSN: 1432-2307
    Keywords: Tracheobronchial amyloidosis ; Electron microscopy ; Amyloid fibril ; Fibroblast
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The author reports on the electron-microscopic examination of the diffuse tracheobronchial amyloidosis of a 51-year-old patient. The amyloid deposits were located in the lamina propria of the tracheal and bronchial mucosa. At the edge of the nodular deposits, condensation and radial arrangement of amyloid fibrils could be seen. Closely connected with the amyloid, active fibroblasts were present and their cytoplasm contained amyloid fibrils. The cell membrane of the fibroblasts was missing in part. Intracellular amyloid fibrils mingled with extracellular deposits. It can be assumed that active fibroblasts play an important role in local amyloid formation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00627013
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    Paper (German National Licenses)
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  • 7
    Electronic Resource
    Electronic Resource
    Amyloidosis of the stomach (1981)
    Springer
    Virchows Archiv 391 (1981), S. 227-240 
    Details
    ISSN: 1432-2307
    Keywords: Amyloid fibril ; Epithelial cell ; Myofibroblast ; Intracellular filaments
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The author reports on a rare case of local amyloidosis (amyloid tumour) of the stomach. The first electron-microscopic study of such case was performed by her. She observed a large number of microfilaments in the mucus producing cells of the stomach mucosa, and assumed this to be indicative of a pathologic mucus secretion. The epithelial cells involved also changes indicating the disorder of protein secretion. She treats in detail the electron-microscopic characteristics of cellular elements found in amyloid. The closest relationship to amyloid deposits was shown by myofibroblasts. They probably play an important role in the formation of local amyloid.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00437599
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    Paper (German National Licenses)
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